Mabil (500mcg/ml) 1ml, 10 Ampoule Injections

Mecobalamin Injection is a form of Vitamin B12 used to treat and manage conditions caused by Vitamin B12 deficiency, such as neuropathy (nerve damage), pernicious anemia, and certain types of anemia. It is a coenzyme of Vitamin B12 that plays a key role in the formation of red blood cells, proper nerve function, and the synthesis of DNA. Mecobalamin is often used to address symptoms related to nerve disorders, including tingling, numbness, and pain, and is sometimes prescribed to improve nerve regeneration in patients with diabetic neuropathy. The injection is typically administered intramuscularly or subcutaneously and is often used when oral supplementation is not effective or suitable. It is a more active form of Vitamin B12 compared to cyanocobalamin, and is particularly useful in the treatment of neurological symptoms associated with Vitamin B12 deficiency.

Mecobalamin

Vitamin

injection

Following are the uses of Mecobalamin Injection:

• Used to treat and prevent Vitamin B12 deficiency, which may lead to conditions like anemia or neuropathy.
• Effective in managing peripheral neuropathy, including diabetic neuropathy and other nerve-related disorders.
• Helps in the treatment of pernicious anemia, a condition where the body cannot absorb enough Vitamin B12 from the digestive tract.
• Often used to improve nerve regeneration and reduce symptoms like tingling, numbness, and pain in patients with nerve damage.
• Prescribed for conditions associated with Vitamin B12 deficiency that affect the central nervous system, including cognitive disturbances and memory problems.
• Used to manage conditions like methylmalonic acidemia and homocystinuria, where Vitamin B12 deficiency is a contributing factor.
• Can be used in conjunction with other treatments for vitamin B12 malabsorption disorders.

Following are the doses of Mecobalamin Injection:

• For Vitamin B12 deficiency

• For neuropathies (e.g., diabetic neuropathy)

• For pernicious anemia

In case of a Mecobalamin Injection overdose, it is important to seek immediate medical attention. While Mecobalamin is generally considered safe, an excessive dose could potentially lead to adverse effects such as allergic reactions or gastrointestinal disturbances. The healthcare provider may monitor vital signs and perform supportive care if necessary. As there is no specific antidote for an overdose of Mecobalamin, treatment will typically involve managing the symptoms and preventing complications. It is important to provide the healthcare professional with details of the dosage taken and the time of administration to guide appropriate intervention.

If you miss a dose of Mecobalamin Injection, it is important to administer it as soon as you remember, unless it is nearly time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you are unsure about what to do or if you have missed several doses, contact your healthcare provider for advice on how to proceed. They will guide you on whether an adjustment in your treatment plan is necessary.

To use Mecobalamin Injection typically, it is administered by a healthcare professional either as an intramuscular or subcutaneous injection. The frequency of the injection may vary depending on the specific condition being treated, but it is usually given once a day or as prescribed.

Following are the situations when Mecobalamin Injection should not be used:

• Should not be used in individuals with a known allergy to Mecobalamin or any of the components of the injection.
• Contraindicated in patients with Leber's disease (a hereditary optic neuropathy), as Vitamin B12 may worsen the condition.
• Not recommended in patients with a history of hypersensitivity or severe allergic reactions to other forms of Vitamin B12.
• Should not be used in cases where the underlying condition is not due to Vitamin B12 deficiency, as it may not address other causes of symptoms.
• Contraindicated in patients with certain types of anemia (such as folate-deficiency anemia) where B12 supplementation may not be appropriate.
• Should not be used for the treatment of Vitamin B12 deficiency without confirming the diagnosis through proper blood tests, as the treatment may mask other serious health conditions.

The side effects of Mecobalamin may include:

• Headache
• Nausea
• Vomiting
• Diarrhea
• Rash
• Itching
• Dizziness
• Chest pain
• Swelling
• Allergic reactions

Following are the precautions and warnings for Mecobalamin Injection:

• Use with caution in patients with kidney or liver impairment, as adjustments may be required for proper dosing and monitoring.
• Mecobalamin should be used with caution in individuals with a history of heart disease, particularly if they are at risk for arrhythmias, as large doses may cause changes in heart rhythm.
• It should be used cautiously in pregnant or breastfeeding women, as the safety of high-dose Mecobalamin during pregnancy and lactation has not been well established. Consult a healthcare provider before use.
• People with a history of sensitivity or allergic reactions to Vitamin B12 should be closely monitored during treatment, and if signs of an allergic reaction occur (e.g., rash, itching, difficulty breathing), the injection should be stopped immediately.
• Long-term use or high doses of Mecobalamin should be monitored for signs of Vitamin B12 toxicity, especially if the patient has conditions like kidney disease.
• Careful monitoring of blood levels and neurological status should be performed in patients with neuropathy to assess treatment response and potential side effects.
• Do not self-administer the injection without proper guidance and training from a healthcare provider, as improper technique can lead to complications like infections or tissue damage.
• It should be used with caution in individuals with other neurological conditions, as B12 supplementation may have varying effects on nerve function.

Following are the drug interactions for Mecobalamin Injection:

• Mecobalamin may interact with certain anticonvulsants (e.g., phenytoin, phenobarbital), potentially reducing the effectiveness of Vitamin B12 supplementation.
• Use with caution when combined with other Vitamin B12 supplements or multivitamins, as excessive doses can cause Vitamin B12 toxicity.
• Mecobalamin may interfere with the effectiveness of certain chemotherapy drugs, especially those used to treat cancers such as leukemia, affecting their absorption or efficacy.
• The injection may interact with medications like chloramphenicol, which can reduce the therapeutic effects of Mecobalamin by inhibiting red blood cell production.
• Alcohol consumption may decrease the absorption of Vitamin B12, potentially reducing the effectiveness of Mecobalamin treatment.
• Caution is advised when used with certain antibiotics like tetracycline, as they may interact and reduce Vitamin B12 levels in the body.
• The use of Mecobalamin alongside other B vitamins or folic acid should be monitored to prevent over-supplementation and potential interactions.

Following are the food interactions for Mecobalamin Injection:

• Excessive alcohol intake can reduce the absorption of Vitamin B12, potentially making the treatment less effective.
• A diet low in Vitamin B12 or lacking in animal-derived foods (such as meat, dairy, and eggs) may decrease the effectiveness of Mecobalamin treatment, as these foods are natural sources of Vitamin B12.
• High doses of Vitamin C (ascorbic acid) taken in large quantities may interfere with the absorption of Vitamin B12 and reduce its effectiveness, particularly when consumed in conjunction with Mecobalamin.
• Antacids or foods high in calcium, magnesium, or iron may interfere with the absorption of Vitamin B12, so it is advisable to avoid consuming these foods in large amounts when taking Mecobalamin.
• If you are on a vegetarian or vegan diet, you may require additional sources of Vitamin B12, as plant-based diets typically do not provide sufficient amounts, and Mecobalamin supplementation may be necessary.

Mecobalamin Injection should be stored in a cool, dry place away from direct sunlight and heat. It should be kept at room temperature, typically between 15°C and 30°C (59°F and 86°F), and should not be frozen. Always ensure the vial is tightly closed to avoid contamination. Dispose of any unused or expired injections according to local regulations or the instructions provided by your healthcare provider or pharmacist. Do not dispose of the medication in household trash or down the toilet unless instructed to do so. Proper disposal helps prevent accidental ingestion or misuse by others. If you're unsure about how to dispose of the injection, consult your pharmacist for guidance.

Here are some quick tips for using Mecobalamin Injection:

• Follow your healthcare provider's instructions on dosage and frequency to ensure effective treatment.
• If you have dietary restrictions, such as a vegan or vegetarian diet, consult your doctor about the need for Mecobalamin supplementation, as these diets may lack sufficient Vitamin B12.
• Avoid excessive alcohol consumption, as it can interfere with the absorption of Vitamin B12 and reduce the efficacy of Mecobalamin.
• Inform your healthcare provider of any other medications, including over-the-counter drugs, supplements, or herbal products, to prevent potential drug interactions.
• Keep track of any symptoms or changes in your health, and report any side effects or unusual reactions to your doctor promptly.
• Do not self-adjust the dose or frequency of injections.