Macmol (1g) 100ml, 1 Infusion

Paracetamol 1000mg injection works primarily by inhibiting the synthesis of prostaglandins, which are involved in the mediation of pain and inflammation. It selectively blocks cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system, reducing the production of prostaglandin E2 (PGE2). This action helps decrease the sensitivity of pain receptors and lowers the body's temperature threshold, thereby reducing fever. Paracetamol's mechanism is believed to involve both peripheral and central effects, with the central effects being more prominent, leading to analgesia and antipyresis without significant anti-inflammatory action.

Analgesic, antipyretic.

Injection

The following are the uses of Paracetamol 1000mg injection:

• Used for relieving severe pain, such as post-operative pain, after major surgeries or traumatic injuries.
• Used for managing acute pain crises in conditions like sickle cell disease.
• Used for reducing fever and high temperatures in critical care settings.
• Used for providing analgesia during labor and childbirth.
• Used for treating severe pain associated with cancer and palliative care.
• Used for alleviating pain and discomfort in patients who cannot take oral medications.

In the case of an overdose of Paracetamol 1000mg injection, immediate medical intervention is necessary. Symptoms may include nausea, vomiting, abdominal pain, and potential liver damage. Prompt treatment can help prevent severe complications. Seek emergency care, and provide healthcare professionals with details of the overdose, including the amount and timing. They will initiate appropriate measures to manage the overdose and support the patient's recovery.

In the case of a missed dose of Paracetamol 1000mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for guidance on how to safely adjust your dosing schedule.

To administer Paracetamol 1000mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, inject the entire contents of the vial slowly, and then safely dispose of the used needle and syringe.

Here are the conditions or situations when Paracetamol 1000mg injection should not be administered:

• Avoid in patients with known hypersensitivity or severe allergic reactions to paracetamol or any of its excipients.
• Not recommended for individuals with severe liver disease or acute liver failure.
• Contraindicated in patients with severe kidney impairment or end-stage renal disease.
• Should not be used in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of hemolysis.
• Avoid in patients with severe blood disorders like anemia or thrombocytopenia.
• Not suitable for individuals with heart failure or severe cardiovascular disease.
• Do not administer if the patient has a history of severe skin reactions or Stevens-Johnson syndrome.
• Avoid in patients with metabolic disorders like phenylketonuria.

The side effects of Paracetamol 1000mg injection may include:

• Skin rash or itching
• Nausea and vomiting
• Stomach pain
• Loss of appetite
• Dark-colored urine
• Jaundice (yellowing of the skin or eyes)
• Liver damage (rare)
• Allergic reactions (such as hives, swelling, or difficulty breathing)

Following are the precautions and warnings for Paracetamol 1000mg Injection:

• Not recommended for long-term use; prolonged use may lead to liver damage.
• Do not exceed the recommended dosage; overdose can cause severe liver damage.
• Patients with liver or kidney impairment should use with caution and under medical supervision.
• Alcohol consumption should be avoided or limited as it may increase the risk of liver toxicity.
• Paracetamol may interact with other medications; inform your doctor about all medications you are taking.
• Seek immediate medical attention if you experience symptoms like nausea, vomiting, abdominal pain, or jaundice, as these may indicate liver problems.
• This medication is intended for intravenous use only and should be administered by trained healthcare professionals.
• Not recommended for children under 12 years old without medical advice.

Following are the drug interactions for Paracetamol 1000mg injection:

• Prolonged use with opioids like codeine or tramadol may increase the risk of liver damage and respiratory depression.
• It can interact with warfarin and other anticoagulants, altering their effectiveness and potentially increasing bleeding risk.
• Paracetamol may increase the concentration of certain anticonvulsants like phenytoin, requiring dosage adjustments.
• When combined with isoniazid, the risk of liver damage is elevated, and close monitoring is necessary.
• The effect of chloramphenicol, a broad-spectrum antibiotic, may be reduced when used with Paracetamol.
• Using Paracetamol with barbiturates can lead to increased metabolism of both drugs, affecting their efficacy.
• It may also interact with cholestyramine, potentially reducing the absorption and effectiveness of Paracetamol.

Following are the food interactions for Paracetamol 1000mg injection:

• Avoid excessive alcohol consumption while using Paracetamol, as it can increase the risk of liver damage, especially with long-term use.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Paracetamol, potentially altering its effectiveness.
• Avoid high-fat meals before or after taking the injection as it may delay the absorption of Paracetamol, leading to reduced effectiveness.
• Caffeine-rich foods and beverages may increase the metabolism of Paracetamol, potentially reducing its duration of action.
• Some herbal supplements, like St. John's Wort, may interact with Paracetamol, affecting its metabolism and potentially reducing its efficacy.
• Consuming a balanced diet rich in antioxidants may support the liver's ability to process Paracetamol and reduce the risk of liver-related side effects.
• Avoid foods containing high levels of tyramine, such as aged cheeses, cured meats, and fermented foods, as they may interact with Paracetamol, affecting blood pressure.
• Ensure adequate hydration when using Paracetamol injections to aid in the body's processing of the medication.

Paracetamol 1000mg injection should be stored in a controlled environment, specifically at room temperature between 15-25°C (59-77°F). Protect the injection from direct sunlight and moisture, ensuring it is kept in its original packaging, tightly sealed, to maintain its integrity. Avoid exposing the medication to extreme temperatures, such as storing it in the refrigerator, freezer, or near heat sources like ovens or radiators, as this can compromise its effectiveness. Always check the expiration date on the packaging, and never use the injection if it is past its expiry. Dispose of any unused or expired Paracetamol injection responsibly; do not flush it down the toilet or pour it into the sink. Consult your pharmacist or healthcare provider for appropriate disposal methods to ensure environmental safety. Keep this medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Paracetamol 1000mg Injection:

• Administer the injection under medical supervision to ensure proper dosage and technique.
• Ensure the injection is given in a clean and sterile environment to prevent infection.
• Check the expiry date of the injection before use.
• Follow the prescribed dosage and administration frequency as directed by your doctor.
• Dispose of used needles and syringes safely in designated sharps containers.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• Store the injection as directed on the packaging, typically at room temperature away from direct sunlight.
• Seek immediate medical attention if you experience any adverse reactions or severe side effects.