Maxolon (5mg/5ml) 50ml Syrup

Metoclopramide, a medication commonly administered in syrup or suspension form, primarily acts as a dopamine D2 receptor antagonist in the chemoreceptor trigger zone (CTZ) and the upper gastrointestinal tract. By blocking these receptors, metoclopramide effectively reduces nausea and vomiting. It also displays prokinetic properties by binding to serotonin 5-HT4 receptors in the gastrointestinal tract, stimulating gastric motility and accelerating the movement of food through the digestive system. This dual mechanism of action makes metoclopramide a valuable medication for managing gastrointestinal symptoms, particularly in cases where enhanced gastric emptying is desired.

Antiemetic, prokinetic

Suspension

The following are the uses of Metoclopramide Syrup/Suspension:

• Used for treating gastroesophageal reflux disease in children and adolescents.
• Used to relieve symptoms of a certain type of stomach issue (gastroparesis) in adults and children.
• Used to prevent nausea and vomiting caused by cancer chemotherapy or after surgery.
• Used to treat persistent heartburn and indigestion.
• Used to stimulate gastric emptying in patients with delayed stomach emptying.
• Used to manage symptoms of nausea and vomiting in various conditions.
• Used to facilitate diagnostic imaging of the stomach and intestines.

To be taken as per doctor's prescription

In the case of an overdose of Metoclopramide Syrup/Suspension, the severity of symptoms can vary depending on the amount ingested. Common signs may include drowsiness, agitation, and extrapyramidal symptoms such as involuntary movements. In severe cases, overdose can lead to acute dystonic reactions, neuroleptic malignant syndrome, or serotonin syndrome. Medical intervention is necessary, and treatment may involve symptomatic and supportive care.

In the case of a missed dose of Metoclopramide Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It's important to follow your prescribed treatment plan for the best therapeutic outcomes.

To take Metoclopramide Syrup/Suspension, shake the bottle well, then use the provided measuring device to measure the prescribed dose, which should be taken as directed by your healthcare provider, typically 30 minutes before meals and at bedtime, with a maximum of four doses per day.

Here are the situations when Metoclopramide Syrup/Suspension should not be used:

• Should not be administered to individuals with a known allergy or hypersensitivity to Metoclopramide or other similar medications.
• Contraindicated in patients with suspected or confirmed gastrointestinal bleeding, perforation, or obstruction.
• Not suitable for individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Should be avoided in patients with pheochromocytoma or suspected pheochromocytoma.
• Should not be used in patients with severe liver impairment or liver disease.
• Contraindicated in individuals with suspected or confirmed bowel obstruction, including pyloric stenosis.
• Not recommended for use in patients with a history of a blood clot or deep vein thrombosis.
• Should be used with caution and avoided if possible in patients with hypertension, as it may cause an increase in blood pressure.
• Contraindicated in patients with a suspected or confirmed tumor of the adrenal gland (pheochromocytoma).
• Should not be given to infants and children with jaundice, as it may worsen the condition.

The side effects of Metoclopramide Syrup/Suspension may include:

• Fatigue and drowsiness
• Restlessness or agitation
• Dizziness
• Diarrhea
• Muscle spasms or involuntary movements
• Anxiety or nervousness
• Insomnia
• Skin rashes or itching

Following are the precautions and warnings for Metoclopramide Syrup/Suspension:

• Do not use in patients with a known hypersensitivity or allergy to Metoclopramide or other dopamine antagonists.
• This medication should be used with caution in patients with a history of epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Metoclopramide can cause extrapyramidal reactions; if these occur, discontinue the drug immediately.
• Patients with a history of kidney or liver disease should be monitored closely as Metoclopramide is primarily metabolized in these organs.
• Elderly patients may be more sensitive to the effects and side effects of this medication, particularly tardive dyskinesia.
• Metoclopramide may cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• It is recommended to use the lowest effective dose for the shortest duration necessary to treat the condition.

Following are the drug interactions for Metoclopramide Syrup/Suspension:

• Concomitant use with medications like levodopa or dopamine agonists may reduce the effectiveness of these Parkinson's disease treatments.
• Metoclopramide can increase the effects of opioid pain medications, leading to enhanced sedation and respiratory depression.
• It may decrease the absorption of certain antibiotics, such as ciprofloxacin and levofloxacin, reducing their effectiveness.
• When combined with sedatives or hypnotics, it can cause excessive drowsiness and sedation.
• Antipsychotic drugs' effects can be enhanced by Metoclopramide, increasing the risk of extrapyramidal symptoms.
• Caution is advised with digoxin, as Metoclopramide may alter its absorption and increase digoxin levels.
• It may interact with certain anti-nausea medications, like ondansetron, potentially reducing their effectiveness.

Following are the food interactions for Metoclopramide Syrup/Suspension:

• Alcohol consumption should be avoided as it can enhance the sedative effects of Metoclopramide, increasing the risk of dizziness and drowsiness.
• Grapefruit and its juice are to be avoided as they may elevate Metoclopramide levels in the blood, potentially intensifying side effects due to the inhibition of CYP3A4 enzyme metabolism.
• Caffeine intake should be limited as it can exacerbate the stimulant effects of Metoclopramide, leading to increased heart rate and nervousness.
• High-fat meals may slightly delay the absorption of Metoclopramide, but this is generally not clinically significant.
• Avoid large meals and heavy foods that can slow gastric emptying, as Metoclopramide is used to aid digestion and relieve symptoms of gastroparesis.
• Ensure adequate fluid intake to prevent dehydration, especially if experiencing increased bowel movements or vomiting.
• Follow a diet recommended by your healthcare provider, focusing on easily digestible foods to support the medication's effectiveness.
• Consult your pharmacist or healthcare provider for specific dietary recommendations based on your medical history and conditions.

Metoclopramide Syrup/Suspension requires careful storage and disposal to maintain its integrity and ensure safety. Store the medication in a cool, dry area, preferably at room temperature, shielded from sunlight and moisture. Maintain the original container's tight seal to prevent contamination. Avoid bathroom storage or placement near heat sources like stoves or radiators, as temperature fluctuations can compromise the medication's effectiveness. Prior to use, verify the packaging's expiration date, and if the syrup is unused or past its prime, exercise caution when disposing of it. Refrain from flushing it down toilets or drains; instead, seek advice from a pharmacist or healthcare professional for appropriate disposal methods. Lastly, keep the medication inaccessible to children to avert accidental ingestion.

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Following are the quick tips for Metoclopramide Syrup/Suspension:

• Administer the prescribed dosage as directed by your healthcare professional.
• Ensure thorough mixing by shaking the bottle vigorously before each use.
• Use a measuring device for accurate dosage, especially with children.
• Avoid mixing the syrup with other liquids; water is the best option.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Do not freeze the suspension.
• Regularly monitor and assess the patient's response to the medication.