Maxolon (10mg) 100 Tablets

Metoclopramide, a dopamine D2 receptor antagonist, primarily exerts its effects through a combination of central and peripheral mechanisms. In the brain, it crosses the blood-brain barrier and acts on the chemoreceptor trigger zone (CTZ) in the medulla, blocking dopamine receptors. This action suppresses the signal to the vomiting center, thereby inhibiting nausea and vomiting. Additionally, metoclopramide enhances gastrointestinal motility by increasing acetylcholine release at the myenteric plexus and inhibiting dopamine receptors in the enteric nervous system. This dual action accelerates gastric emptying, improves gastrointestinal transit, and reduces gastroesophageal reflux, contributing to its therapeutic benefits in gastrointestinal disorders.

Antiemetic, prokinetic.

Tablet

The following are the uses of Metoclopramide Tablet:

• Used for treating nausea and vomiting, especially in cases of chemotherapy-induced nausea.
• Used for accelerating gastric emptying in patients with gastroparesis.
• Used for relieving symptoms of gastroesophageal reflux disease (GERD) and heartburn.
• Used for stimulating gastrointestinal motility in post-operative patients.
• Used for managing symptoms of diabetes-related gastric stasis.
• Used for improving feeding tolerance in infants with poor feeding.
• Used for preventing aspiration pneumonia in at-risk individuals.

To be taken as per doctor's prescription

In the case of an overdose of Metoclopramide Tablets, it is crucial to recognize the potential severity of the situation. Common symptoms may include drowsiness, agitation, and extrapyramidal reactions. Prompt medical intervention is vital, as severe cases can lead to acute dystonic reactions, neuroleptic malignant syndrome, or serotonin syndrome. Medical professionals should be contacted immediately to ensure appropriate treatment and management of these potentially life-threatening complications.

In the case of a missed dose of Metoclopramide Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Metoclopramide Tablets, swallow the tablet whole with a full glass of water, preferably before meals, following the dosage instructions provided by your healthcare professional, typically taken 30 minutes before meals and at bedtime, with the duration of treatment determined by your medical condition.

Following are the conditions/situations when Metoclopramide Tablet should not be used:

• Should not be given to individuals with a known allergy or hypersensitivity to Metoclopramide or similar medications.
• Contraindicated in patients with a history of bleeding, blockage, or perforation in the digestive system.
• Not suitable for patients with epilepsy or seizures, as it may lower the seizure threshold.
• Should be avoided in individuals with pheochromocytoma (a rare adrenal gland tumor).
• Contraindicated in patients with suspected or confirmed bowel obstruction.
• Not recommended for use in patients with severe kidney or liver disease.
• Should not be used in individuals with a history of Parkinson's disease.
• Avoid in patients with a history of depression or suicidal thoughts.
• Contraindicated in pregnant or breastfeeding women unless the potential benefits outweigh the risks.
• Should not be used in children under 1 year of age.

The side effects of Metoclopramide Tablet may include:

• Drowsiness or fatigue
• Restlessness or agitation
• Diarrhea
• Muscle spasms or involuntary movements
• Anxiety or depression
• Insomnia
• Skin rashes or itching
• Difficulty breathing or swallowing

Following are the precautions and warnings for Metoclopramide Tablet:

• Not recommended for long-term use due to the risk of developing tardive dyskinesia, a serious movement disorder.
• Patients with a history of seizures or epilepsy should use with caution as it may lower the seizure threshold.
• May cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Elderly patients may be more sensitive to the side effects, especially neurological effects.
• Caution is advised in patients with kidney or liver impairment, as dosage adjustments may be required.
• Not recommended for use in children, especially those under 1 year of age, due to potential serious side effects.
• Patients with a history of depression or other mental health disorders should be closely monitored, as the medication may worsen these conditions.

Following are the drug interactions for Metoclopramide Tablet:

• Concomitant use with medications that prolong QT interval (e.g., certain antiarrhythmics, antipsychotics, or antibiotics) can increase the risk of cardiac arrhythmias.
• Metoclopramide may interact with lithium, increasing the risk of lithium toxicity. Close monitoring of lithium levels is recommended.
• It can reduce the absorption of certain medications, including antibiotics like tetracyclines and antifungals like ketoconazole. Consider separating doses.
• The effectiveness of metoclopramide may be decreased when used with medications that have a similar mechanism of action, such as other dopamine antagonists.
• Opioid pain medications may interact with Metoclopramide, potentially leading to excessive sedation and respiratory depression.
• Caution is advised when combining Metoclopramide with other drugs that lower the seizure threshold, as it may increase the risk of seizures.
• The use of alcohol with Metoclopramide is not recommended, as it may enhance the sedative effects and impair motor skills.

Following are the food interactions for Metoclopramide Tablet:

• Alcohol consumption should be avoided as it can increase the sedative effects of Metoclopramide, leading to enhanced drowsiness and dizziness.
• Grapefruit and its juice are to be avoided as they can increase the drug levels in the blood by inhibiting the enzyme CYP2D6, potentially raising the chances of adverse effects.
• High-fat meals can delay the absorption of Metoclopramide, slowing down its effectiveness.
• Caffeine intake should be monitored as it may exacerbate side effects like nervousness, anxiety, and insomnia.
• Foods rich in tyramine, such as aged cheeses, cured meats, and certain types of beer, should be limited as Metoclopramide can interact with tyramine, causing a spike in blood pressure.
• Metoclopramide may reduce your body's ability to absorb nutrients like vitamin B12 and iron; hence, dietary adjustments might be necessary.
• Avoid large meals and opt for smaller, frequent ones to prevent gastroparesis-related complications, a condition that Metoclopramide is often prescribed for.
• Always adhere to the dosing instructions provided by your healthcare professional for the best outcomes.

Metoclopramide Tablets should be stored in a secure and dry location, preferably at room temperature, away from direct sunlight, moisture, and heat sources like ovens or radiators. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to light and humidity. It is crucial to regularly check the expiration date on the packaging and dispose of any expired or unused tablets promptly. When disposing of Metoclopramide Tablets, do not flush them down the toilet or pour them into a drain. Instead, consult your pharmacist or healthcare professional for safe and environmentally friendly disposal methods. Additionally, ensure that the medication is kept out of children's reach to prevent accidental consumption, as it can be harmful if ingested without proper medical supervision.

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Following are the quick tips for Metoclopramide Tablet:

• Consult your doctor before use, especially if you have any medical conditions or are taking other medications.
• Take the tablet as directed by your doctor, usually 30 minutes before meals and at bedtime.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• If you experience drowsiness, avoid driving or operating machinery.
• Inform your doctor if you have Parkinson's disease, epilepsy, or depression before taking this medication.
• Store the tablets at room temperature, away from moisture and heat.
• Do not share this medication with others, even if their symptoms seem similar.