Nebra (0.3%) 5g Eye Ointment

Tobramycin Ointment, an aminoglycoside antibiotic, exerts its bactericidal effect by binding to specific proteins on the bacterial cell membrane, particularly the 30S subunit of bacterial ribosomes. This binding interferes with protein synthesis, which is essential for the survival and multiplication of bacteria. The primary mechanism involves disrupting the decoding process during protein translation. Tobramycin binds to the 16S rRNA of the 30S ribosomal subunit, leading to the misreading of mRNA, preventing the proper formation of peptide bonds, and ultimately resulting in the production of nonfunctional or toxic proteins. This disruption of protein synthesis leads to the death of susceptible bacteria, effectively controlling and eliminating the bacterial infection on the skin or eye surface when applied topically.

Aminoglycoside antibiotic.

Ointment

The following are the uses of Tobramycin Ointment:

• Used for treating external eye infections, particularly those caused by bacteria.
• Used for preventing and controlling bacterial infections in patients with eye injuries or post-surgery.
• Used for reducing the risk of infection in corneal ulcers or abrasions.
• Used for managing chronic conjunctivitis with bacterial involvement.
• Used for improving eye health in patients with bacterial keratitis.
• Used for adjunct therapy in ocular infections, enhancing the effectiveness of other treatments.
• Used for preventing infection during extended contact lens wear or in conditions that increase the risk of eye infections.
• Used for its broad-spectrum antibacterial properties to target a range of bacterial strains affecting the eyes.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For sinusitis- Use two drops in each affected sinus, every eight hours for 10 days.
• For urinary tract infections- Use one drop in the affected eye every eight hours for seven days.
• For bacterial conjunctivitis- Use one to two drops in the affected eye every six hours.
• For pneumonia- Dose varies depending on the severity of the case and the specific treatment plan. Use under medical supervision.

In the case of an overdose of Tobramycin Ointment, it is important to recognize the signs and symptoms. These may include skin irritation, redness, and itching at the application site. If a large amount is accidentally ingested, symptoms such as nausea, vomiting, and diarrhea may occur. Promptly seek medical advice if you suspect an overdose, and provide healthcare professionals with information regarding the amount and timing of the overdose to ensure appropriate treatment and management.

In the case of a missed dose of Tobramycin Ointment, it is important to apply the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra ointment to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure the best treatment outcome. It is recommended to set reminders or alarms to help you stay on track with your medication routine.

To apply Tobramycin Ointment, gently pull down the lower eyelid, squeeze a thin strip of ointment along the inside of the eyelid, and close your eyes for 1-2 minutes to allow the medication to distribute evenly over the eye surface.

Following are the conditions when Tobramycin Ointment should not be used:

• Avoid using Tobramycin Ointment if you have a known allergy or sensitivity to any aminoglycoside antibiotics or any of the ingredients in the ointment.
• Do not use the ointment if you have a perforated eardrum or a history of hearing problems, as it can cause further damage.
• Not suitable for individuals with a history of myasthenia gravis, as it may worsen muscle weakness.
• Contraindicated in patients with a history of hypersensitivity reactions to similar medications.
• Avoid using if you have a skin condition or infection at the site of application that is not caused by bacteria.
• Do not use in the eyes or on mucous membranes, as it is formulated specifically for external skin use.
• Tobramycin Ointment should not be used for extended periods, especially in children, without regular monitoring of kidney function.

The side effects of Tobramycin Ointment may include:

• Skin irritation at the application site
• Redness or rash
• Itching
• Dryness or flakiness of the skin
• Stinging or burning sensation
• Allergic reactions (skin swelling, hives)
• Hearing changes or loss (in some cases)
• Kidney problems (with prolonged or excessive use)

Following are the precautions and warnings for Tobramycin Ointment:

• Avoid contact with eyes or mucous membranes; if accidental contact occurs, rinse thoroughly with water.
• Tobramycin Ointment is for external use only; do not ingest or insert into the body.
• Do not use the ointment if you have a known allergy to tobramycin or any other aminoglycoside antibiotics.
• Prolonged use of the ointment may result in the overgrowth of non-susceptible organisms, including fungi; monitor for signs of secondary infection.
• Do not use the ointment on deep or puncture wounds, animal bites, or severe burns without medical supervision.
• Keep the treated area clean and avoid using other topical medications unless advised by a healthcare professional.
• Discontinue use and consult a doctor if you experience signs of allergic reaction, increased skin irritation, or severe side effects.
• Store the ointment at room temperature and keep it out of reach of children and pets.

Following are the drug interactions for Tobramycin Ointment:

• Tobramycin can interact with other topical antibiotics, such as neomycin or gentamicin, leading to reduced effectiveness or increased risk of bacterial resistance.
• Concomitant use with systemic aminoglycosides may increase the risk of ototoxicity and nephrotoxicity.
• The absorption of tobramycin can be affected by the presence of other drugs with similar chemical properties, potentially altering its effectiveness.
• Corticosteroids, when used together, might enhance the risk of skin atrophy or other local side effects.
• Some eye medications, when used simultaneously, may reduce the efficacy of tobramycin or cause adverse eye reactions.
• Topical anesthetics, if used before or after tobramycin application, can increase the risk of corneal damage.
• Antacids containing aluminum or magnesium, when used concurrently, might decrease the absorption of tobramycin in some formulations.

Following are the food interactions to be aware of when using Tobramycin Ointment:

• Tobramycin Ointment should be used with caution in patients who are also receiving systemic aminoglycoside therapy, as concurrent use may increase the risk of ototoxicity and nephrotoxicity.
• Avoid applying the ointment near mealtimes, especially if treating facial areas. Wash your hands thoroughly before and after application to avoid accidental ingestion.
• No specific food restrictions are associated with Tobramycin Ointment, but maintaining a balanced diet is essential for overall health.
• There is no known interaction with alcohol, but excessive alcohol consumption may impact the overall healing process.
• Certain foods or beverages may cause irritation or sensitivity when applied topically, so observe for any local reactions.
• Tobramycin Ointment should be applied only to the affected areas, ensuring it does not come into contact with food or beverages.
• Consult your healthcare provider if you have concerns about potential interactions with specific dietary items.
• Always follow the prescribed dosage and application instructions provided by your healthcare professional.

Tobramycin Ointment should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid exposing the ointment to extreme temperatures by not storing it in the bathroom or near heat sources like ovens or radiators. Always check the expiration date on the packaging, and if the ointment has expired or is no longer needed, do not flush it down the toilet or drain; instead, follow appropriate disposal guidelines by consulting your pharmacist or healthcare provider. Keep the medication away from children to prevent accidental ingestion.

Following are the quick tips for Tobramycin Ointment:

• Clean and dry the affected area before applying the ointment for better absorption.
• Apply a thin layer of ointment to the affected area, gently massaging it into the skin.
• Wash your hands thoroughly before and after application to prevent contamination.
• Avoid applying the ointment to open wounds or broken skin.
• Continue using the ointment for the full prescribed duration, even if symptoms improve.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Inform your healthcare provider if symptoms persist or worsen during treatment.

Tobramycin is an antibiotic that is used to treat various infections. When taking Tobramycin, it is important to monitor your health, and your doctor may order specific lab tests to effectively manage your treatment, which may include the following: