Nutrifactor Melatonin (3mg) 90 Tablets

Melatonin, the primary hormone produced by the pineal gland, plays a crucial role in regulating sleep-wake cycles and maintaining circadian rhythms. The mechanism of action of melatonin tablets involves its direct interaction with specific melatonin receptors in the brain, particularly MT1 and MT2 receptors. When melatonin binds to these receptors, it initiates a cascade of intracellular signaling events, primarily involving the inhibition of cyclic adenosine monophosphate (cAMP) production. This, in turn, leads to a decrease in neuronal activity in the suprachiasmatic nucleus (SCN), the master clock of the body, promoting sleep and regulating the sleep-wake cycle. By mimicking the natural melatonin produced by the body, melatonin tablets help regulate sleep patterns, making it an effective treatment for various sleep disorders and jet lag.

Melatonin Tablet:

Tablet

The following are the uses of Melatonin Tablet:

• Used for improving sleep patterns and treating insomnia.
• Used for regulating the body's internal clock, especially in jet lag and shift work.
• Used for supporting the treatment of sleep disorders in children with autism or ADHD.
• Used for reducing anxiety and promoting relaxation.
• Used for supporting cancer treatment and reducing side effects of chemotherapy.
• Used for managing chronic pain and headaches.
• Used for supporting immune function and reducing inflammation.
• Used for improving mood and reducing symptoms of depression.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Jet Lag- The recommended dosage ranges from 0.5mg to 5mg, ideally taken close to bedtime after arriving at your destination, and for a few days.
• Sleep Disorders- For short-term treatment, a dose of 1mg to 3mg is suggested, taken before bed. Start with the lowest dose possible and gradually increase it after observing your body's response. Consult a doctor for personalized dosing recommendations.
• Blindness Retinal Disease- The recommended starting dose is somewhat between 3-10mg and divided into several doses daily. The severity of the disease dictates the dose, with more advanced cases requiring higher doses.
• Neurodegenerative Diseases- The starting dose is typically between 0.5mg to 3mg and is taken orally. This dose may be adjusted upwards or downwards depending on the response and tolerance. In consultation with a medical professional, a higher dose of more than 3mg can be considered, and should be monitored closely for safety and effectiveness.
• Fibromylagia and Rheumatoid Arthritis- For these diseases, a generally recommended starting dose is between 1-3mg.
• Seasonal Affective Disorders- This type of depression is typically treated with a dose of 2-3mg orally, taken about 30-60 minutes before bedtime.
• Other Indications- For any other indications, it is best to consult with a medical professional who can provide you with a specific dosage based on your unique condition and consider any counterindications with other concurrent medications you may be taking.

In the case of an overdose of Melatonin Tablet, it is important to remain calm and seek medical advice promptly. While melatonin is generally considered safe, excessive consumption may lead to symptoms such as drowsiness, headache, or dizziness. Contact a healthcare professional or a poison control center for guidance on managing the situation effectively. They can provide specific instructions based on the amount ingested and the individual's health status. Quick action can help prevent any potential adverse effects and ensure a swift recovery.

In the case of a missed dose of Melatonin Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one. If you frequently miss doses, it is recommended to set reminders or use a pill organizer to help you stay on track with your medication regimen. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take the Melatonin Tablet, place the tablet under your tongue and allow it to dissolve completely, preferably before bedtime, following the dosage instructions provided by your healthcare professional, typically starting with a lower dose and adjusting as needed.

Following are the conditions/situations when Melatonin Tablet should not be used:

• Should not be taken by individuals with a known allergy or hypersensitivity to melatonin or any of the tablet's components.
• Not suitable for children and adolescents without medical advice, as it may interfere with growth and development.
• Contraindicated for pregnant or breastfeeding women due to potential risks to the fetus or infant.
• Avoid using melatonin if you have a history of seizures or epilepsy, as it can lower the seizure threshold.
• Do not take melatonin if you have a sleep disorder that causes sudden muscle weakness (cataplexy).
• Not recommended for individuals with autoimmune disorders, as it may stimulate the immune system.
• Should not be used in people with liver or kidney disease without consulting a doctor, as it may require dosage adjustments.
• Melatonin is not recommended for those with a history of depression or other mood disorders, as it can affect mood and emotional state.
• Avoid using melatonin if you are scheduled for surgery, as it can interfere with anesthesia and post-operative recovery.
• Do not use melatonin if you have a bleeding disorder or are taking blood thinners, as it may increase the risk of bleeding.

The side effects of Melatonin Tablet may include:

• Headache
• Dizziness
• Fatigue or drowsiness during the day
• Vivid dreams or nightmares
• Nausea
• Confusion or disorientation
• Skin rashes or itching
• Changes in blood pressure

Following are the precautions and warnings for Melatonin Tablet:

• Not suitable for individuals with a known allergy to melatonin or any of its ingredients.
• May cause drowsiness; patients should avoid activities requiring alertness like driving or operating machinery.
• Consult a doctor if you have underlying medical conditions, especially liver or kidney issues.
• Elderly patients should use with caution and under medical supervision.
• Avoid alcohol consumption while taking melatonin as it may intensify drowsiness.
• Do not exceed the recommended dosage; overdose can lead to severe side effects.
• If you are pregnant, breastfeeding, or planning to become pregnant, consult a healthcare professional before use.

Following are the drug interactions for Melatonin Tablet:

• Alcohol may enhance the sedative effects of melatonin, leading to increased drowsiness and impaired alertness.
• Melatonin may reduce the effectiveness of contraceptive drugs, including birth control pills, patches, or rings, potentially affecting their reliability.
• It can interact with anticoagulant/antiplatelet drugs like warfarin or aspirin, possibly increasing the risk of bleeding.
• Antihypertensive medications may have their effects reduced by melatonin, potentially impacting blood pressure control.
• Antipsychotic drugs may have their effects altered by melatonin, potentially affecting their efficacy and side effect profile.
• Melatonin may decrease the effectiveness of immunosuppressant medications, potentially affecting transplant outcomes or autoimmune disease management.
• It can interact with diabetes medications, possibly affecting blood sugar control and increasing the risk of hypoglycemia or hyperglycemia.

Following are the food interactions for Melatonin Tablet:

• Consuming alcohol with Melatonin may increase drowsiness and impair your thinking, so it is advisable to avoid alcohol or limit its use.
• Caffeine-containing products like coffee, tea, energy drinks, and certain soft drinks should be avoided as they can reduce the effectiveness of Melatonin and disrupt sleep patterns.
• Avoid eating large meals close to bedtime when taking Melatonin, as this may reduce the effectiveness of the medication and cause discomfort during sleep.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of Melatonin, potentially leading to increased side effects.
• Avoid high-fat meals as they may delay the absorption of Melatonin, affecting its onset of action.
• Chocolate, especially dark chocolate, contains caffeine and theobromine, which can stimulate the nervous system and potentially reduce the effectiveness of Melatonin.
• Spicy foods may cause stomach irritation and discomfort, potentially disrupting sleep when taken with Melatonin.
• Certain herbs and spices like St. John's Wort, valerian root, and ginseng may interact with Melatonin and affect sleep patterns, so consult your healthcare provider before combining them.

Melatonin Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original packaging should be tightly sealed to maintain its integrity and effectiveness. It is crucial not to store the tablets in areas prone to heat or humidity, like bathrooms or kitchen cabinets near appliances. Always adhere to the expiration date on the packaging, and when disposing of unused or expired tablets, avoid flushing them or pouring them down the drain. Consult your pharmacist or local waste management guidelines for the appropriate disposal method. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Melatonin Tablet:

• Consult your doctor or pharmacist for personalized advice on melatonin use.
• Take the tablet as directed by your healthcare provider, typically 30-60 minutes before bedtime.
• Start with a low dose and gradually increase if needed under medical supervision.
• Use melatonin for short-term sleep issues; long-term use should be monitored.
• Avoid driving or operating machinery until you know how melatonin affects you.
• If you're pregnant, breastfeeding, or have medical conditions, consult a healthcare professional before use.
• Store melatonin tablets in a cool, dry place, away from direct sunlight and moisture.

Melatonin is a hormone found in many cells in the body and its primary function is to regulate sleep-wake cycles, also known as the circadian rhythm. It is widely used as a supplement to help alleviate symptoms of jet lag or adjust to nighttime shift work, as well as for its perceived benefits in regulating sleep. You can take it in the form of capsules, tablets, or liquid supplements. While there is some scientific evidence supporting its use for sleep, it may cause some side effects. Some reports suggest daytime drowsiness, headaches, and irritability. Also, it may also lead to mood swings, impaired memory and concentration, and in some cases, anxiety and depression. Melatonin is generally considered safe and is classified as a "generally recognized as safe" (GRAS) substance by the Food and Drug Administration (FDA). Lab tests and doctor's appointments are not required for monitoring use, unless you have an underlying medical condition or are on other medications. Overall, while melatonin is useful for assisting with sleep, it is important to be aware of its potential side effects, and it should be used with caution, particularly by avoiding driving or operating heavy machinery after consumption, until you understand its effects on your body.