Kids 0-9 Night 100ml Syrup

Dextromethorphan, an antitussive, acts centrally to suppress the cough reflex by elevating the threshold for coughing. Paracetamol (acetaminophen) is a widely used antipyretic and analgesic that acts by inhibiting the synthesis of prostaglandins, which are involved in pain and fever signaling. Promethazine HCl, an antihistamine, blocks H1-receptor sites, preventing activation by histamine, thus reducing symptoms such as nausea, vomiting, and allergic reactions. This combination of drugs works synergistically to provide relief from cough, pain, fever, and allergic symptoms.

Dextromethorphan, Paracetamol, Promethazine

Antitussive, Analgesic, Antihistamine

Suspension

The following are the uses of dextromethorphan, Paracetamol, Promethazine (HCl) Syrup/Suspension:

• Used for relieving coughs associated with a cold, allergy, or respiratory infection.
• Used to temporarily reduce fever and relieve minor aches and pains.
• Used to treat nausea, vomiting, and allergic reactions.
• Effective in suppressing dry, hacking coughs and improving sleep.
• Can be used to alleviate pain and reduce inflammation.
• Helps manage symptoms of upper respiratory tract infections.
• Provides short-term relief from various types of pain, including headaches and muscle aches.
• May be utilized as a pre-operative medication to reduce anxiety and produce sedation.

In the case of an overdose of Dextromethorphan, Paracetamol, and Promethazine (HCl) Syrup/Suspension, symptoms may include severe drowsiness, respiratory depression, rapid heart rate, and impaired coordination. Prompt medical intervention is necessary, as these symptoms can lead to serious complications. Treatment may involve gastric lavage, activated charcoal, and supportive care to manage respiratory and cardiovascular functions. Immediate medical care should be sought for any suspected overdose.

In the case of a missed dose of Dextromethorphan, Paracetamol, and Promethazine (HCl) Syrup/Suspension, take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent dosing routine for the medication's effectiveness.

To administer the dextromethorphan, Paracetamol, and Promethazine (HCl) syrup/suspension, shake the bottle well, measure the prescribed dose with the provided dosing cup or oral syringe, and take it orally, preferably with a full glass of water, following the instructions provided by your healthcare professional regarding dosage and frequency.

Here is a list of conditions and situations when Dextromethorphan, Paracetamol, and Promethazine (HCl) Syrup/Suspension should not be used:

• Not suitable for individuals with a known allergy or hypersensitivity to dextromethorphan, paracetamol, or promethazine or any of the excipients in the syrup/suspension.
• Should not be administered to children under 2 years of age due to potential respiratory depression and other severe side effects.
• Contraindicated in patients with respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), or severe breathing difficulties, as promethazine can worsen respiratory symptoms.
• Not recommended for individuals with liver disease or impaired liver function, as paracetamol is primarily metabolized by the liver.
• Should be avoided in patients with kidney disease or renal impairment, as it may affect the metabolism and excretion of the medication.
• Contraindicated in patients with a history of seizures or conditions that lower the seizure threshold, as dextromethorphan can potentially induce seizures.
• Should not be used in individuals with gastrointestinal obstruction or severe constipation, as promethazine can affect gastrointestinal motility.
• Not suitable for patients with glaucoma or increased intraocular pressure, as promethazine may worsen these conditions.
• Should be avoided in individuals with a history of bone marrow depression or blood disorders, as promethazine can affect blood cell production.
• Contraindicated during the last trimester of pregnancy due to potential harm to the fetus.

The side effects of dextromethorphan, Paracetamol, and Promethazine (HCl) Syrup/Suspension may include:

• Drowsiness or sedation
• Dry mouth
• Nausea and vomiting
• Blurred vision
• Constipation
• Dizziness
• Allergic reactions (such as rash, itching, or swelling)
• Difficulty urinating

Following are the precautions and warnings for dextromethorphan, Paracetamol, Promethazine (HCl) Syrup/Suspension:

• Avoid use in patients with known hypersensitivity or allergy to any of the active ingredients (dextromethorphan, paracetamol, or promethazine) or related compounds.
• This medication may cause drowsiness or dizziness, so patients should not drive or operate heavy machinery until they know how the medication affects them.
• Caution is advised in patients with liver or kidney disease, as these conditions may require dosage adjustments.
• Promethazine may cause respiratory depression, especially in children and elderly patients. Close monitoring is necessary, and caution should be exercised in patients with respiratory disorders.
• Dextromethorphan should be used with caution in patients with a history of substance abuse, as it may be habit-forming.
• Paracetamol has the potential to cause liver damage if used in high doses or for prolonged periods. Avoid excessive alcohol consumption while taking this medication.
• This medication may cause urinary retention, so caution is advised in patients with prostatic hypertrophy or urinary outflow obstruction.
• Do not exceed the recommended dosage or duration of treatment without medical supervision.

Following are the drug interactions for Dextromethorphan, Paracetamol, and Promethazine (HCl) Syrup/Suspension:

• Alcohol or other central nervous system (CNS) depressants may enhance the sedative effects of Promethazine, leading to increased drowsiness and impaired coordination.
• Monoamine oxidase inhibitors (MAOIs) should not be used with Promethazine due to the risk of severe adverse reactions.
• Dextromethorphan can interact with certain antidepressants (e.g., SSRIs, SNRIs) and increase the risk of serotonin syndrome.
• Promethazine may reduce the effectiveness of levodopa in treating Parkinson's disease.
• Paracetamol can potentially cause liver damage when taken with other acetaminophen-containing products or alcohol.
• It may also interact with anticoagulants, increasing bleeding risk, and affect the metabolism of other drugs processed by the liver.
• Promethazine may enhance the sedative effects of opioids, benzodiazepines, and other CNS depressants.

Following are the food interactions for Dextromethorphan, Paracetamol, and Promethazine (HCl) Syrup/Suspension:

• Alcohol should be avoided or consumed in moderation as it can increase the sedative effects of Promethazine, leading to enhanced drowsiness and impaired coordination.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Dextromethorphan, potentially leading to increased drug levels in the body.
• High-fat meals can delay the absorption of Paracetamol, resulting in a slightly slower onset of action.
• Caffeine-containing beverages like coffee or energy drinks may counteract the sedative effects of Promethazine, reducing its effectiveness in treating symptoms like cough and runny nose.
• Spicy foods may irritate the throat and potentially worsen cough symptoms, so it's advisable to consume milder foods while taking this medication.
• Dairy products, if consumed in large amounts, might temporarily bind with Paracetamol, affecting its absorption. It's best to consume them in moderation.
• Ensure adequate fluid intake to maintain hydration, as dehydration can affect the efficacy of these medications.
• Avoid excessive consumption of sugary foods and drinks, as they can interact with the Paracetamol component, potentially affecting liver function when taken in high doses.

Dextromethorphan, Paracetamol, and Promethazine (HCl) Syrup/Suspension should be stored in a secure location, away from direct sunlight, heat, and moisture. Keep the bottle tightly sealed to maintain its integrity and effectiveness. It is recommended to store it at room temperature, typically between 68°F and 77°F (20°C and 25°C). Always refer to the packaging for specific storage instructions. When disposing of unused or expired syrup, do not pour it down the drain or flush it; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep this medication out of children's reach to prevent accidental consumption, and ensure responsible storage and disposal practices.

Following are the quick tips for Dextromethorphan, Paracetamol, Promethazine (HCl) Syrup/Suspension:

• Consult a healthcare professional for dosage instructions based on age and medical condition.
• Administer the syrup as directed by your doctor or pharmacist.
• Ensure you measure the dose accurately using the provided measuring device.
• Swallow the syrup directly or mix it with a small amount of water for easier consumption.
• Do not mix with hot beverages or alcohol.
• Store the medication at room temperature, away from light and moisture.
• Keep a record of your medication schedule to ensure you don't miss a dose.
• Inform your doctor about any other medications you're taking to avoid potential interactions.