Nixaf (200mg) 10 Tablets

Rifaximin 200mg Tablet's primary mechanism of action is to inhibit bacterial RNA synthesis by binding to the beta-subunit of bacterial RNA polymerase. It primarily targets intestinal bacteria and acts locally within the gastrointestinal tract. Rifaximin is a unique antibiotic because it has low systemic absorption, meaning it remains mostly within the intestines and is not significantly absorbed into the bloodstream. This characteristic allows it to exert its antibacterial effect on intestinal pathogens while minimizing the risk of common systemic antibiotic side effects. The localized action of Rifaximin helps to reduce the overall disruption of the gut microbiota, making it particularly useful in treating gastrointestinal disorders associated with bacterial imbalances.

Antibiotic (Rifamycin derivative)

Tablet

The following are the uses of Rifaximin 200mg Tablet:

• Used for treating diarrhea caused by certain bacteria, effectively reducing gut inflammation.
• Used for managing symptoms of irritable bowel syndrome, providing relief from abdominal pain and improving stool consistency.
• Used for reducing the risk of hepatic encephalopathy recurrence, a brain disorder caused by severe liver disease.
• Used for preventing and treating traveler's diarrhea, a common issue when traveling to regions with potential water contamination.
• Used for supporting the gut-brain axis, potentially improving mood and cognitive function in some patients.
• Used for maintaining a healthy gut microbiome, promoting the growth of beneficial bacteria.
• Used for managing small intestinal bacterial overgrowth (SIBO), reducing excess bacteria in the small intestine.
• Used for its ability to minimize antibiotic-associated diarrhea, a common side effect of certain antibiotic treatments.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Traveler's diarrhea- 200 mg three times a day for 3 days
• Hepatic encephalopathy- 800 mg daily in adults and adolescents >11 kg
• Irritable bowel syndrome- 550 mg daily for 2 weeks, followed by 550 mg every other day for 10 weeks
• Small intestinal bacterial overgrowth- 200 mg three times a day
• Necrotizing enterocolitis- Variable, the dose should be adjusted based on the patient's weight and severity of the disease, follow clinical guidelines
• Ulcerative colitis- Variable, the dose should be based on the patient's weight and severity of disease, follow clinical guidelines

In the case of an overdose of Rifaximin 200mg Tablets, it is important to recognize the potential symptoms. An overdose may lead to an increase in the severity of common side effects, such as gastrointestinal discomfort, nausea, or diarrhea. Promptly contact a healthcare professional or a poison control center for guidance on managing the overdose. They will provide specific instructions based on the individual's condition and the amount ingested.

In the case of a missed dose of Rifaximin 200mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to proceed, as they can guide you on the best course of action to ensure the effectiveness of the treatment.

To take Rifaximin 200mg Tablet, swallow the tablet whole with a glass of water, preferably on an empty stomach, as directed by your healthcare provider, typically two to three times a day.

Following are the conditions or circumstances when Rifaximin 200mg Tablet should not be taken:

• Avoid using this medication if you have a known allergy to Rifaximin or any other rifamycin antibiotics.
• Not suitable for individuals with severe liver impairment or liver disease.
• Contraindicated in patients with a history of hypersensitivity reactions to similar antibiotics.
• Should not be used for the treatment of severe or life-threatening bacterial infections.
• Not recommended for children below 12 years of age due to insufficient data.
• Avoid using this medication if you have a gastrointestinal blockage or severe constipation.
• Not suitable for individuals with a history of severe or persistent diarrhea.

Here are the possible side effects of Rifaximin 200mg Tablet:

• Nausea or vomiting
• Stomach pain or cramps
• Diarrhea or constipation
• Flatulence or bloating
• Headache or dizziness
• Fatigue or weakness
• Changes in bowel habits
• Allergic reactions, including rash, itching, or swelling
• Increased liver enzymes, seen in blood tests
• Severe diarrhea or bloody stools, which may indicate a serious condition called Clostridium difficile-associated diarrhea (rare but serious)

Following are the precautions and warnings for Rifaximin 200mg Tablet:

• Not recommended for individuals with known hypersensitivity or allergy to Rifaximin or other rifamycin derivatives.
• Caution in patients with severe hepatic impairment as Rifaximin is primarily metabolized in the liver.
• Not indicated for the treatment of systemic infections as it has low systemic absorption.
• Should not be used to treat diarrhea caused by pathogens other than E. coli; proper diagnosis is essential.
• May cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for use in children below 12 years of age unless advised by a healthcare professional.
• Safety and effectiveness in pregnant and breastfeeding women have not been established; consult a doctor before use.

Following are the drug interactions for Rifaximin 200mg Tablet:

• Concomitant use with other antibiotics like ciprofloxacin may result in increased risk of Clostridium difficile infection, a serious intestinal condition.
• Rifaximin can reduce the absorption of cyclosporine, impacting its effectiveness. Close monitoring of cyclosporine levels is necessary.
• The blood levels of oral contraceptives might be affected by Rifaximin, potentially reducing their efficacy. Alternative or additional contraceptive methods should be considered.
• Antacids containing magnesium or aluminum can decrease the absorption of Rifaximin, reducing its effectiveness. Separate administration by at least 2 hours.
• Prolonged use with warfarin may lead to an increased risk of bleeding. Regular monitoring of INR (International Normalized Ratio) is recommended.
• Rifaximin may interact with other gastrointestinal medications, such as loperamide, potentially affecting their efficacy or increasing side effects.
• Caution is advised when combining Rifaximin with drugs that affect liver function, as this may alter Rifaximin's metabolism and increase its blood levels.

Following are the food interactions to consider with Rifaximin 200mg Tablet:

• Avoid consuming alcohol during the treatment as it may increase the risk of gastrointestinal side effects and reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Rifaximin, potentially increasing its blood levels and risk of side effects.
• Dairy products like milk, yogurt, and cheese may interfere with the absorption of Rifaximin, so it's best to separate them by a few hours when taking the medication.
• High-fat meals can delay the absorption of Rifaximin, leading to reduced effectiveness. It's advisable to take the medication on an empty stomach or with a low-fat meal.
• Avoid consuming herbal tea containing St. John's Wort as it may reduce the effectiveness of Rifaximin by inducing certain enzymes in the liver.
• Vitamin-rich foods like spinach, kale, and broccoli may enhance the metabolism of Rifaximin, potentially reducing its blood levels. Consider taking the medication a few hours before or after consuming these foods.
• Sugary foods and beverages can potentially interact with Rifaximin, especially in patients with diabetes. Monitor blood sugar levels and consult a doctor for personalized advice.
• Ensure adequate hydration by drinking plenty of water during the treatment, as Rifaximin may cause mild dehydration as a side effect.

Rifaximin 200mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (68°F to 77°F or 20°C to 25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial not to expose the medication to excessive heat or cold, so avoid storing it in the bathroom, kitchen, or inside a vehicle during hot weather. Always check the expiration date before using any medication, and never use Rifaximin tablets if they have passed their expiry date. For proper disposal, do not flush the medication or throw it into the trash. Instead, consult your pharmacist or local waste management authority for guidelines on how to safely dispose of unused or expired medications, ensuring that they do not contaminate the environment. Keep this medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Rifaximin 200mg Tablet:

• Take the tablet as directed by your doctor, typically 3 times a day with meals.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Ensure you complete the full course of medication, even if you feel better early on.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• If you have liver disease, discuss with your doctor before taking this medication.
• Avoid alcohol consumption while using Rifaximin to minimize potential side effects.
• Consult your doctor if you experience severe or persistent diarrhea during treatment.

Rifaximin is an antibiotic that is commonly used to treat intestinal infections and traveler's diarrhea. It is important to note that, while effective, Rifaximin is not a cure-all. You should be aware of any potential side effects. Laboratory tests are not typically required for this medication. However, it is important to consult your physician or pharmacist to confirm if any required laboratory tests are needed to take this medication.It is essential to undertake routine monitoring and follow-up visits to ensure the drug is effective and to mitigate any potential side effects. These appointments also allow your healthcare providers to re-evaluate your condition and adjust your treatment plan if necessary.