Noctamid (1mg) 100 Tablets

Lormetazepam, a benzodiazepine, exerts its therapeutic effects primarily by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. It binds to specific benzodiazepine receptors, which are part of the GABA-A receptor complex. Upon binding, Lormetazepam modulates the opening frequency of chloride ion channels, leading to an increase in chloride ion conductance. This heightened conductance results in neuronal hyperpolarization, making it less likely for these neurons to fire action potentials. By enhancing GABA's inhibitory effects, Lormetazepam reduces neuronal excitability, thereby inducing sedative, anxiolytic, muscle relaxant, and anticonvulsant effects. This mechanism of action is pivotal in its clinical use for the management of insomnia and as a pre-anesthetic medication.

Lormetazepam

Benzodiazepine

Tablet

The following are the uses of Lormetazepam Tablet:

• Used for the short-term treatment of severe or debilitating insomnia.
• Used to help individuals fall asleep faster and improve sleep quality.
• Used in cases where insomnia is causing significant distress or impairment in daily functioning.
• Used to provide relief from symptoms such as difficulty falling asleep, frequent awakenings, or early morning awakenings.
• Used for patients who have difficulty staying asleep due to anxiety or stress-related disorders.
• Used as a short-term solution while addressing the underlying causes of insomnia.
• Used as part of a comprehensive treatment plan for sleep disorders.

To be used as per doctor's precription

In the case of an overdose of Lormetazepam Tablets, several symptoms may manifest. These can include severe drowsiness, confusion, and impaired coordination. Respiratory depression is also a serious concern, potentially leading to a life-threatening condition. It is imperative to seek medical assistance promptly if an overdose is suspected. Timely intervention is crucial to managing the adverse effects and ensuring the best possible outcome for the individual.

In the case of a missed dose of Lormetazepam Tablet, it is important to follow the instructions provided by your healthcare professional. If you remember within a few hours of the missed dose, take the medication as soon as possible. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your doctor if you frequently miss doses or have concerns about managing your medication regimen.

To take Lormetazepam tablets, swallow the prescribed number of tablets whole with a glass of water before bedtime, following the dosage instructions provided by your healthcare professional, ensuring a proper night's rest without interruption.

Here are the conditions or situations when Lormetazepam Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Lormetazepam or other benzodiazepines.
• Contraindicated in patients with severe respiratory insufficiency or sleep apnea, as it can suppress respiratory drive.
• Not recommended for individuals with acute narrow-angle glaucoma.
• Should not be used in patients with severe liver impairment, as it can lead to accumulation of the drug.
• Contraindicated in patients with severe myasthenia gravis, as it can exacerbate muscle weakness.
• Not suitable for individuals with a history of severe depression or suicidal tendencies.
• Should be avoided in patients with a history of drug or alcohol abuse due to the risk of dependence and withdrawal.
• Not recommended for use in children and adolescents under 18 years of age.
• Contraindicated in patients with a history of acute porphyria.
• Should not be used as a primary treatment for psychotic disorders or severe personality disorders.

The side effects of Lormetazepam Tablet may include:

• Drowsiness or fatigue
• Confusion or disorientation
• Muscle weakness
• Coordination problems
• Memory impairment
• Slurred speech
• Dizziness or lightheadedness
• Dry mouth

Following are the precautions and warnings for Lormetazepam Tablet:

• Lormetazepam is a potent medication and should be used with caution, especially in elderly patients, as they may be more sensitive to its effects.
• This medication can cause drowsiness and impaired coordination; patients should avoid driving, operating machinery, or any activity that requires full alertness until they know how the medication affects them.
• Alcohol consumption should be avoided as it can enhance the sedative effects of Lormetazepam.
• Patients with a history of substance abuse or dependence should be closely monitored due to the potential for misuse and addiction.
• Lormetazepam should not be abruptly discontinued; gradual reduction in dosage is recommended to prevent withdrawal symptoms.
• It may cause memory impairment, especially at higher doses, and patients may experience difficulty in remembering events that occurred while under the influence of the medication.
• Patients with respiratory problems such as chronic obstructive pulmonary disease (COPD) or sleep apnea should use Lormetazepam with caution as it can depress respiratory function.
• Pregnant and breastfeeding women should consult their healthcare provider before taking Lormetazepam, as it may have adverse effects on the fetus or infant.

Following are the drug interactions for Lormetazepam Tablet:

• Alcohol and other central nervous system (CNS) depressants, such as opioids or antipsychotics, can enhance the sedative effects of Lormetazepam, leading to increased drowsiness and impaired breathing.
• Strong CYP3A4 inhibitors like ketoconazole and itraconazole may increase Lormetazepam concentrations, potentially causing prolonged sedation and respiratory depression.
• Lormetazepam may increase the effects of other benzodiazepines and non-benzodiazepine hypnotics, requiring dose adjustments.
• Drugs that lower the seizure threshold, such as certain antidepressants and antipsychotics, may increase the risk of seizures when used with Lormetazepam.
• Lormetazepam can potentiate the effects of general anesthetics, and close monitoring is necessary during surgical procedures.
• The efficacy of Lormetazepam may be reduced when used with enzyme inducers like rifampicin, leading to decreased sleep duration and quality.
• Antacids may delay the absorption of Lormetazepam, resulting in a delay in the onset of action.

Following are the food interactions for Lormetazepam Tablet:

• Grapefruit and grapefruit juice should be avoided as they can alter the drug's metabolism, leading to increased blood levels and potential toxicity.
• Alcohol consumption should be avoided as it can enhance the sedative effects of Lormetazepam, causing excessive drowsiness and impaired coordination.
• Caffeine-containing beverages like coffee, tea, or energy drinks may reduce the effectiveness of Lormetazepam, making it harder to achieve a restful sleep.
• Fatty meals might delay the absorption of Lormetazepam, potentially affecting its onset of action.
• Avoid eating large meals close to bedtime when taking Lormetazepam, as it may interfere with the medication's sedative effect.
• Dairy products like milk or yogurt might potentially interact with Lormetazepam, affecting its absorption. It's best to consult a healthcare professional for personalized advice.
• Always take Lormetazepam on an empty stomach as directed by your healthcare provider to ensure optimal absorption and effectiveness.
• Maintain a consistent diet and avoid sudden changes in eating habits while on Lormetazepam to minimize potential food interactions.

Lormetazepam Tablets should be stored securely in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It's crucial to keep this medication out of the reach of children and pets to prevent accidental ingestion. Do not store Lormetazepam in the bathroom or kitchen, as these areas can be exposed to heat and moisture, which may degrade the medication. Always check the expiration date, and if the tablets have passed their expiry, do not use them and dispose of them properly. Consult a pharmacist or local waste disposal company for guidance on how to safely dispose of unused or expired Lormetazepam Tablets.

Yes

Following are the quick tips for Lormetazepam Tablet:

• Take the tablet as directed by your doctor, typically before bedtime.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Ensure you get a full night's sleep (7-8 hours) after taking the medicine.
• Avoid alcohol and other sedatives while using Lormetazepam.
• Do not drive or operate machinery until you know how this medicine affects you.
• Inform your doctor if you have any kidney or liver problems before taking this medication.
• Store the tablets at room temperature, away from moisture and heat.