Noroxin (400mg) 14 Tablets

Norfloxacin 400mg Tablet primarily exerts its antibacterial effect through the inhibition of bacterial DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. This inhibition occurs by binding to the A subunit of DNA gyrase, blocking its activity and leading to the accumulation of double-stranded DNA breaks in bacterial cells, ultimately resulting in cell death. The drug selectively targets bacterial DNA gyrase, showing a higher affinity for this enzyme than for mammalian topoisomerases, which contributes to its therapeutic efficacy and lower toxicity to human cells.

Fluoroquinolone antibiotic.

Tablet

The following are the uses of Norfloxacin 400mg Tablet:

• Used for treating bacterial infections such as urinary tract infections, including bladder and kidney infections.
• Used for managing respiratory tract infections like pneumonia and bronchitis caused by sensitive bacteria.
• Used for gastrointestinal infections, including bacterial diarrhea and typhoid fever.
• Used for skin and soft tissue infections, ensuring they are bacterial in origin.
• Effective for preventing and treating infections in individuals with a weakened immune system.
• Used for treating sexually transmitted infections, specifically gonorrhea, when prescribed by a doctor.
• Useful for post-surgery infection prevention, especially in surgeries related to the urinary or gastrointestinal systems.
• Can be utilized for traveler's diarrhea treatment, but this is not a common indication.

To be taken as per doctor's prescription

In the case of an overdose of Norfloxacin 400mg Tablets, it is important to recognize the signs, which may include nausea, dizziness, and potential damage to the central nervous system. Prompt action is necessary; contact a healthcare professional or poison control center immediately. They will provide guidance on the appropriate steps to take, which may involve inducing vomiting or seeking emergency medical care to mitigate the risks associated with the overdose.

In the case of a missed dose of Norfloxacin 400mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may recommend adjusting your dosage or provide specific instructions to ensure you receive the full benefit of the medication.

To take Norfloxacin 400mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, either one hour before a meal or two hours after a meal, as directed by your healthcare professional.

Here are the conditions and situations when Norfloxacin 400mg Tablet should not be taken:

• Avoid if you have a known allergy to Norfloxacin or other quinolone antibiotics.
• Do not use if you have a history of tendon disorders or tendon rupture after taking quinolone antibiotics.
• Contraindicated in individuals with myasthenia gravis as it can worsen muscle weakness.
• Should not be used in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Not recommended for children and adolescents under 18 years of age, as it may affect bone and joint development.
• Avoid exposure to sunlight or UV rays, as it may increase sensitivity to light and cause severe sunburn.
• Do not take if you have a history of heart rhythm problems or QT prolongation.
• Contraindicated in patients with severe kidney disease, as dosage adjustment is necessary.
• Should not be used in patients with central nervous system (CNS) disorders, such as cerebral arteriosclerosis, epilepsy, or severe anxiety.

The side effects of Norfloxacin 400mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Skin rash or itching
• Photosensitivity (sensitivity to sunlight)
• Confusion and disorientation

Following are the precautions and warnings for Norfloxacin 400mg Tablet:

• Avoid exposure to direct sunlight or UV rays as it may increase sensitivity to light. Protect your skin and eyes during treatment.
• Norfloxacin should not be used in patients with a known hypersensitivity or allergy to it or other quinolone antibiotics.
• Patients with a history of seizures or conditions that lower the seizure threshold should exercise caution, as Norfloxacin may increase the risk of seizures.
• Not recommended for use in children, adolescents, pregnant women, and breastfeeding mothers due to potential risks.
• Elderly patients may be more susceptible to side effects and should be monitored closely.
• May cause dizziness or lightheadedness; patients should avoid driving or operating machinery until they know how the medication affects them.
• Always complete the full course of treatment as prescribed, even if symptoms improve, to ensure the infection is fully treated.

Following are the drug interactions for Norfloxacin 400mg Tablet:

• Probenecid can reduce the elimination of Norfloxacin, leading to increased drug levels and potential toxicity.
• Antacids containing magnesium, aluminum, or calcium may decrease the absorption of Norfloxacin, reducing its effectiveness.
• Theophylline levels may be increased when used with Norfloxacin, possibly leading to theophylline toxicity.
• NSAIDs (e.g., ibuprofen) may enhance the risk of CNS stimulation and seizures when taken with Norfloxacin.
• Sucralfate can decrease the absorption of Norfloxacin, thus reducing its efficacy.
• May enhance the effects of oral anticoagulants (e.g., warfarin), requiring close monitoring of coagulation parameters.
• The risk of tendon disorders, including tendon rupture, is increased when Norfloxacin is combined with corticosteroids.

Following are the food interactions to consider with Norfloxacin 400mg Tablet:

• Avoid excessive caffeine intake from coffee, tea, or energy drinks as it may increase side effects like nervousness, anxiety, and insomnia.
• Limit the consumption of dairy products like milk, cheese, and yogurt, as they can reduce the absorption of Norfloxacin, making it less effective.
• Avoid high-fat meals as they can delay the absorption of the medication, leading to reduced effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of the drug, potentially increasing its concentration in the body.
• Avoid alcohol consumption during treatment, as it can intensify the side effects and increase the risk of central nervous system (CNS) side effects.
• Ensure adequate hydration and maintain a balanced diet to support overall health during the course of medication.
• There are no specific food requirements for Norfloxacin, but maintaining a healthy diet can aid in recovery.

Norfloxacin 400mg Tablets should be stored in a cool, dry place, preferably at room temperature (around 25°C). Keep the medication in its original container, tightly sealed, to maintain its integrity and protect it from moisture and light. Avoid exposure to direct sunlight as it can degrade the medication. It is crucial to keep this medication out of the reach of children and pets to prevent accidental ingestion. Do not use the tablets if the packaging is damaged or shows signs of tampering. Dispose of any unused or expired tablets responsibly; do not flush them down the toilet or throw them into the trash. Consult your pharmacist or local waste management authority for guidance on safe disposal practices.

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Following are the quick tips for Norfloxacin 400mg Tablet:

• Take the tablet with a full glass of water to ensure proper swallowing.
• Avoid taking it with dairy products or calcium-rich foods as they may interfere with absorption.
• Maintain a consistent dosing schedule by taking the tablet at the same time each day.
• Do not crush or chew the tablet; swallow it whole for optimal effectiveness.
• Inform your doctor about all your medications to prevent potential drug interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Discontinue use and consult your doctor if you experience severe side effects or allergic reactions.