Novonorm (1mg) 30 Tablets

Repaglinide, a medication found in the Repaglinide 1MG Tablet, primarily acts as an insulin secretagogue, stimulating the pancreas to release insulin rapidly. It achieves this by blocking ATP-sensitive potassium channels on the pancreatic beta cells, leading to their depolarization. This depolarization activates voltage-gated calcium channels, allowing calcium to enter the beta cells, which then triggers the release of insulin. This mechanism is particularly effective in promoting insulin secretion at mealtimes, as it is activated in response to elevated blood glucose levels.

Meglitinide analog.

Tablet

The following are the uses of Repaglinide 1MG Tablet:

• Used for stimulating the pancreas to release insulin, effectively treating type 2 diabetes.
• Used to control blood sugar levels, preventing hyperglycemia.
• Used in managing diabetes, especially when lifestyle changes and diet adjustments are insufficient.
• Used to improve insulin response after meals, reducing post-meal blood sugar spikes.
• Used as part of a comprehensive diabetes management plan, often combined with exercise and diet.
• Used to lower the risk of diabetes-related complications when taken as prescribed.
• Used to enhance overall blood sugar control and diabetes management.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Take one tablet per day as your doctor suggests.
• Your doctor will determine the treatment length based on your symptom severity.

In the case of an overdose of Repaglinide 1MG Tablets, it is important to recognize the potential severity of the situation. Symptoms may include severe hypoglycemia, leading to dizziness, sweating, and confusion. If you suspect an overdose, seek medical advice promptly. Treatment involves monitoring blood glucose levels and providing supportive care to manage symptoms effectively. Quick action is essential to prevent complications and ensure the best possible outcome.

In the case of a missed dose of Repaglinide 1MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication routine. It's crucial to maintain a consistent medication schedule for optimal effectiveness.

To take Repaglinide 1MG Tablet, swallow the tablet whole with a glass of water, preferably before a meal, as directed by your healthcare professional, and follow the prescribed dosage instructions provided by your doctor.

Following are the conditions when Repaglinide 1MG Tablet should not be taken:

• Should not be used in individuals with a known allergy to Repaglinide or related substances.
• Not suitable for patients with type 1 diabetes mellitus or diabetic ketoacidosis.
• Contraindicated in patients with severe liver disease or those with a history of liver problems.
• Should not be used if you have a severe infection, serious injury, or are experiencing surgery and related stress.
• Not recommended for individuals with a history of heart disease or those who have recently had a heart attack.
• Must not be taken if you are pregnant, planning to become pregnant, or breastfeeding.
• Avoid if you have a condition called 'Hemolytic anemia' or a glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Not suitable for individuals with a history of pancreatitis (inflammation of the pancreas).
• Should not be used in children and adolescents below 18 years of age.
• Avoid if you have a condition called 'Porphyria', a group of disorders that affect the skin and nervous system.

The side effects of Repaglinide 1MG Tablet may include:

• Hypoglycemia (low blood sugar)
• Weight gain
• Headache
• Nausea and vomiting
• Diarrhea
• Joint pain
• Allergic reactions (skin rash, itching)
• Visual disturbances (blurred or impaired vision)

Following are the precautions and warnings for Repaglinide 1MG Tablet:

• Not recommended for individuals with type 1 diabetes or diabetic ketoacidosis; it is specifically designed for type 2 diabetes.
• Patients with liver or kidney problems should use this medication with caution and under medical supervision as dosage adjustments may be necessary.
• May cause hypoglycemia (low blood sugar); monitor blood glucose levels regularly and be aware of the symptoms of hypoglycemia.
• Elderly patients may be more susceptible to the hypoglycemic effects of this medication.
• Should be used with caution in patients with gastrointestinal diseases as it may affect drug absorption.
• Not recommended for individuals with a known allergy to Repaglinide or any of its components.
• Always inform your doctor about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Repaglinide 1MG Tablet:

• Repaglinide may interact with other oral antidiabetic drugs, insulin, sulfonamides, and other medications metabolized by CYP2C8 and CYP3A4 enzymes, leading to altered blood glucose levels.
• Concomitant use with gemfibrozil can significantly increase repaglinide concentrations, potentially resulting in hypoglycemia.
• The risk of hypoglycemia may increase when taken with other drugs known to lower blood sugar, such as beta-blockers, ACE inhibitors, or certain antibiotics.
• Repaglinide may affect the action of anticoagulants like warfarin, requiring close monitoring of INR (International Normalized Ratio).
• Caution is advised when using with CYP3A4 inducers (e.g., rifampicin, phenytoin), as they may reduce repaglinide levels and decrease its effectiveness.
• CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can increase repaglinide concentrations, necessitating dose adjustments.
• Repaglinide may interact with HMG-CoA reductase inhibitors (statins), increasing the risk of myopathy and rhabdomyolysis.

Following are the food interactions for Repaglinide 1MG Tablet:

• Avoid consuming grapefruit and grapefruit juice as they can significantly impact the drug's metabolism, leading to increased drug levels and potential side effects.
• Alcohol consumption should be minimized or avoided as it can cause an additive effect, increasing the risk of hypoglycemia.
• High-fat meals may delay the absorption of Repaglinide, affecting its effectiveness.
• Consuming large amounts of garlic can potentially decrease blood sugar, leading to hypoglycemia when combined with Repaglinide.
• Fenugreek, a common spice, may also lower blood sugar levels, requiring close monitoring when taken with this medication.
• Apple cider vinegar might enhance the hypoglycemic effect of Repaglinide, so consult a doctor for dosage adjustments.
• Licorice, a sweet herb, can decrease the effectiveness of Repaglinide by inhibiting its metabolism.
• Ginger, known for its gastrointestinal benefits, may lower blood sugar levels, necessitating caution when combined with this medication.

Repaglinide 1MG Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The medication bottle should be tightly sealed to maintain its integrity and effectiveness. It is crucial not to expose the tablets to excessive heat or cold, and they should be kept away from stoves, heaters, or other heat sources. Always check the expiration date, and dispose of any unused or expired tablets promptly. Proper disposal methods should be followed, avoiding flushing or pouring them down the drain. Consult a pharmacist for guidance on safe disposal practices to prevent environmental contamination. Keep the medication out of children's reach to prevent accidental consumption.

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Following are the quick tips for Repaglinide 1MG Tablet:

• Take the tablet as directed by your doctor, usually before meals.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• Maintain a consistent meal schedule; take the tablet 30 minutes before meals.
• If you skip a meal, you may need to skip the tablet as well; consult your doctor.
• Avoid alcohol as it can cause low blood sugar and interfere with the medication.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.