Oflobid (400mg) 10 Tablets

Ofloxacin 400mg Tablet primarily exerts its antibacterial effect through the inhibition of bacterial DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. By binding to the DNA-gyrase-DNA complex, ofloxacin prevents the re-ligation of cleaved DNA strands, leading to the accumulation of double-stranded DNA breaks and subsequent bacterial cell death. This mechanism selectively targets bacterial cells, as DNA gyrase is not present in mammalian cells, contributing to the drug's relative safety and efficacy in treating bacterial infections.

Quinolone antibiotic

Tablet

The following are the uses of Ofloxacin 400mg Tablet:

• Used for treating bacterial infections such as pneumonia and bronchitis.
• Used to combat urinary tract infections and kidney infections.
• Effective against skin and soft tissue infections, including cellulitis and boils.
• Can be prescribed for sexually transmitted infections like gonorrhea.
• Helps manage bone and joint infections, including septic arthritis.
• Used in the treatment of typhoid fever.
• Provides relief from certain eye and ear infections.
• May be used for other bacterial infections as advised by a medical professional.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• The dosage of Ofloxacin prescribed for adults varies between 400 mg and 800 mg, depending on the type of infection treated.
• You should take Ofloxacin tablet with a full glass of water, with or without food.

In the case of an overdose of Ofloxacin 400mg Tablets, several symptoms may occur, including nausea, vomiting, dizziness, and headaches. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice immediately and provide the necessary information to the healthcare professional, such as the number of tablets taken and the time of ingestion. Prompt action can help manage the situation effectively and ensure appropriate treatment.

In the case of a missed dose of Ofloxacin 400mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to adjust your dosage and ensure the best treatment outcome. It is advisable to set a reminder or keep a medication schedule to help you remember to take your medication on time.

To take Ofloxacin 400mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, without crushing or chewing the tablet.

Following are the conditions or situations when Ofloxacin 400mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Ofloxacin or other quinolone antibiotics.
• Contraindicated in patients with a history of myasthenia gravis.
• Not recommended for individuals with a history of seizures or epilepsy.
• Avoid use in patients with a history of tendon disorders or tendon rupture.
• Should not be used in patients with a history of heart rhythm problems (QT prolongation).
• Contraindicated in patients with severe kidney disease who require dialysis.
• Not suitable for children and adolescents under 18 years of age.
• Avoid use during pregnancy and breastfeeding.
• Do not use in patients with a history of sensitivity to light (photosensitivity).

The side effects of Ofloxacin 400mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Insomnia (difficulty sleeping)
• Skin rash or itching
• Tendinitis or tendon rupture (rare but serious)
• Central Nervous System (CNS) effects,anxiety, restlessness, confusion, or hallucinations.

Following are the precautions and warnings for Ofloxacin 400mg Tablet:

• Do not take this medication if you are allergic to Ofloxacin or other quinolone antibiotics.
• Ofloxacin should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Avoid exposure to direct sunlight or UV rays, as Ofloxacin can increase skin sensitivity and may cause severe sunburn.
• Elderly patients may be more susceptible to Ofloxacin side effects, especially those related to tendons and joints.
• Patients should maintain adequate hydration during treatment to reduce the risk of kidney-related side effects.
• Inform your doctor if you have a history of epilepsy or seizures, as Ofloxacin may lower the seizure threshold.
• Do not drive or operate heavy machinery if you experience dizziness, blurred vision, or other central nervous system side effects.
• Pregnant and breastfeeding women should consult their doctor before taking Ofloxacin, as it may cause harm to the fetus or infant.

Following are the drug interactions for Ofloxacin 400mg Tablet:

• Theophylline levels may be increased, leading to potential toxicity.
• May reduce the effectiveness of oral live attenuated typhoid vaccine.
• Concomitant use with other drugs that prolong the QT interval (e.g., certain antiarrhythmics, antipsychotics, or antidepressants) can increase the risk of cardiac arrhythmias.
• Antacids containing calcium, magnesium, or aluminum may decrease the absorption of Ofloxacin, reducing its effectiveness.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of seizures when used with Ofloxacin.
• Probenecid can increase Ofloxacin levels in the body, potentially increasing the risk of side effects.
• The efficacy of Ofloxacin may be reduced when taken with iron or zinc supplements.

Following are the food interactions for Ofloxacin 400mg Tablet:

• Avoid caffeine-containing products like coffee, tea, and energy drinks as they may increase the side effects of Ofloxacin, leading to restlessness and nervousness.
• Dairy products such as milk, yogurt, and cheese should be consumed with caution as they can decrease the absorption of Ofloxacin, reducing its effectiveness. Consider separating dairy intake from medication timing.
• Alcohol should be avoided as it can increase the risk of Ofloxacin's side effects, particularly affecting the central nervous system, leading to dizziness, drowsiness, and impaired coordination.
• Maintain a consistent fluid intake and stay well-hydrated throughout the medication course to prevent potential kidney complications.
• Avoid high-sugar foods and beverages as they can interfere with the absorption of Ofloxacin and potentially prolong the treatment duration.
• Consuming a diet rich in lean proteins, whole grains, and a variety of fruits and vegetables can support overall health and aid in recovery during the treatment period.
• There are no specific food restrictions with Ofloxacin, but maintaining a balanced diet is generally recommended for optimal health.

Ofloxacin 400mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and extreme temperatures. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity and effectiveness. Do not remove the tablets from their blister packs unless you are about to take them. Always check the expiration date, and if the tablets have passed their expiry, do not use them and dispose of them carefully. Proper disposal methods are essential; do not flush the medication down the toilet or pour it into a drain. Consult your pharmacist or local waste management guidelines for safe disposal practices to protect the environment. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Ofloxacin 400mg Tablet:

• Take the tablet as directed by your doctor, usually once or twice daily.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Complete the full course of medication as prescribed, even if you feel better after a few days.
• Avoid excessive sunlight exposure and use sunscreen when outdoors during treatment.
• Inform your doctor if you have any kidney or liver problems before taking this medication.
• Store the tablets at room temperature, away from moisture and heat.
• Do not share this medication with others, even if they have similar symptoms.

Ofloxacin is a broad-spectrum antibiotic prescribed for oral use to treat bacterial infections. While the medication does not typically require routine laboratory monitoring, it is essential to undergo necessary lab tests to monitor your health and ensure the safe and effective use of the drug. These tests are designed to check for potential side effects or adverse reactions and help you and your medical provider track your health. They include assessments such as: