Omsana-AM (10/20mg) 20 Tablets

Amlodipine 10mg and Olmesartan 20mg both work synergistically in the tablet to lower blood pressure by targeting different mechanisms in the body. Amlodipine belongs to the calcium channel blocker class of drugs. It inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells, leading to relaxation of these muscle cells. This relaxation causes vasodilation, which decreases peripheral vascular resistance and reduces blood pressure. Olmesartan, on the other hand, is an angiotensin II receptor blocker (ARB). It blocks the angiotensin II hormone from binding to its receptors in the body, primarily in the vascular smooth muscle. Angiotensin II is a powerful vasoconstrictor, so by blocking its effects, Olmesartan causes blood vessels to relax, resulting in decreased blood pressure.

Amlodipine 10mg, Olmesartan 20mg

Angiotensin II Receptor Blocker, Calcium Channel Blocker.

Tablet

The following are the uses of Amlodipine 10mg, Olmesartan 20mg Tablet:

• Used for managing hypertension, effectively lowering blood pressure.
• Used for treating high blood pressure to reduce the risk of associated health issues.
• Used for improving blood flow and relaxing blood vessels.
• Used for preventing the narrowing of blood vessels, allowing better circulation.
• Used for long-term management of hypertension in combination with other medications.
• Used for controlling blood pressure to maintain a healthier cardiovascular system.
• Used for reducing the strain on the heart caused by high blood pressure.

To be taken as per doctor's prescription

In the case of an overdose of Amlodipine 10mg and Olmesartan 20mg tablets, individuals may experience symptoms such as dizziness, lightheadedness, and a rapid or irregular heartbeat. Other potential effects include hypotension (low blood pressure), excessive peripheral vasodilation, and tachycardia. It is important to seek medical advice promptly if an overdose is suspected, as healthcare professionals can provide guidance and treatment to manage these symptoms effectively.

In the case of a missed dose of Amlodipine 10mg, it is generally recommended to take the missed dose as soon as you remember, but if it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Olmesartan 20mg Tablet, if a dose is missed, take it as soon as you remember, however, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing regimen. It's important to note that if you miss multiple doses or have concerns, consult your healthcare provider for specific instructions.

To take Amlodipine 10mg and Olmesartan 20mg tablets, swallow the tablets whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Following are the conditions/situations when Amlodipine 10mg, Olmesartan 20mg Tablet should not be used:

• Should not be used in patients with a known allergy to Amlodipine, Olmesartan, or any other angiotensin II receptor blockers.
• Contraindicated in patients with severe liver disease or biliary obstruction.
• Not recommended for individuals with aortic valve stenosis or hypertrophic cardiomyopathy.
• Should not be used in patients with hypotension (low blood pressure).
• Contraindicated during pregnancy or breastfeeding.
• Avoid in patients with severe coronary artery disease or acute myocardial infarction.
• Not suitable for individuals with severe renal impairment or patients who have recently had a kidney transplant.

The side effects of Amlodipine 10mg, Olmesartan 20mg Tablet may include:

• Dizziness or lightheadedness
• Headache
• Fatigue or weakness
• Swelling of the ankles and feet (peripheral edema)
• Nausea or stomach pain
• Skin rash or itching
• Rapid or irregular heartbeat
• Muscle cramps

Following are the precautions and warnings for Amlodipine 10mg, Olmesartan 20mg Tablet:

• This medication is contraindicated in patients with a known allergy to amlodipine, olmesartan, or related drugs. Discontinue use and seek medical attention if an allergic reaction occurs.
• Blood pressure should be monitored regularly while on this medication, especially during the initial phase of treatment.
• Caution in patients with liver disease, as amlodipine is primarily metabolized by the liver.
• Olmesartan may cause a decrease in kidney function, especially in patients with existing kidney problems. Regular kidney function tests are recommended.
• May cause dizziness or lightheadedness; patients should rise slowly from a sitting or lying position to prevent falls.
• Not recommended for use during pregnancy or breastfeeding unless advised by a healthcare professional.
• Inform your doctor about all other medications you are taking, especially diuretics or other blood pressure medications, to avoid potential drug interactions.
• Store the medication at room temperature, away from moisture and heat, and keep it out of reach of children.

Following are the drug interactions for Amlodipine 10mg, Olmesartan 20mg Tablet:

• Concomitant use with other antihypertensive medications (e.g., beta-blockers, ACE inhibitors) may result in additive effects on blood pressure, requiring close monitoring.
• Grapefruit juice can increase the blood levels of amlodipine, potentially leading to increased side effects. Avoid excessive consumption.
• Olmesartan may reduce the effectiveness of diuretics, requiring dosage adjustments.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may diminish the antihypertensive effect of amlodipine and olmesartan.
• Amlodipine can enhance the effects of antihypertensive medications and increase the risk of hypotension when taken with nitrates.
• Drugs metabolized by CYP3A4 enzyme, such as cyclosporine, may have increased blood levels when taken with amlodipine.
• Caution is advised when combining with potassium-sparing diuretics or potassium supplements, as it may lead to hyperkalemia.
• Antifungal medications like ketoconazole can increase the effects of amlodipine and olmesartan.

Following are the food interactions for Amlodipine 10mg and Olmesartan 20mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the blood levels of amlodipine, leading to a higher risk of side effects.
• Alcohol may cause a decrease in blood pressure, which can be additive to the blood pressure-lowering effect of amlodipine and olmesartan, potentially causing dizziness or lightheadedness.
• Avoid excessive salt (sodium) intake as it can counteract the blood pressure-lowering effect of these medications.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed moderately as olmesartan may increase potassium levels in the body.
• Avoid high-fat meals as they can increase the absorption of amlodipine, potentially leading to higher blood levels and increased side effects.
• Licorice should be avoided as it can reduce the effectiveness of olmesartan by decreasing the levels of a substance called aldosterone.
• Certain herbal supplements like St. John's Wort may affect the metabolism of these drugs and should be used with caution.
• Always consult your healthcare provider for personalized advice regarding food and drug interactions.

Amlodipine 10mg, Olmesartan 20mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial to avoid exposure to extreme temperatures, so refrain from storing them in the bathroom or near heat sources. Always check the expiration date, and if the tablets are no longer needed or have expired, do not flush them or pour them down the drain. Consult your pharmacist or healthcare provider for appropriate disposal methods to ensure environmental safety. Keep this medication out of children's reach to prevent accidental consumption.

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Following are the quick tips for Amlodipine 10mg, Olmesartan 20mg Tablet:

• Always take the medication as directed by your doctor.
• Ensure you understand the dosage instructions; take it at the same time daily.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• It can be taken with or without food, but consistency is key.
• Inform your doctor about all medications you are taking.
• Store the medication in a cool, dry place, away from direct sunlight.
• Regularly monitor your blood pressure and report any concerns to your doctor.