One Alpha (2mcg/ml) 20ml Oral Drops

Alfacalcidol, a synthetic vitamin D analog, exerts its therapeutic effects by mimicking the actions of naturally occurring vitamin D hormones in the body. Upon administration, alfacalcidol is rapidly converted in the liver to the active form of vitamin D, calcitriol. Calcitriol binds to vitamin D receptors (VDR) present in various target tissues, primarily the intestines, kidneys, and bones. This binding triggers a cascade of intracellular events, leading to increased intestinal absorption of calcium and phosphate. In the kidneys, it promotes calcium reabsorption and enhances the production of active vitamin D. By regulating calcium and phosphate metabolism, alfacalcidol helps maintain proper bone mineralization, supporting bone health and treating conditions associated with calcium and vitamin D deficiencies.

Alfacalcidol 2mg

Vitamin D analogue

Drop

The following are the uses of Alfacalcidol 2mg Drop:

• Used for treating and preventing low levels of calcium or phosphate in the blood, often caused by kidney or parathyroid gland issues.
• Used for managing calcium deficiency in conditions like hypoparathyroidism and pseudohypoparathyroidism.
• Used for supporting bone health and treating bone-related disorders, including rickets and osteomalacia.
• Used for regulating calcium and phosphate metabolism in patients with chronic kidney disease.
• Used for preventing and treating muscle spasms and cramps associated with calcium and vitamin D deficiencies.
• Used for improving calcium absorption, especially in individuals with conditions affecting the intestine.
• Used for maintaining optimal bone density and reducing the risk of fractures in specific medical scenarios.
• Used for managing certain metabolic bone diseases under medical supervision.

In the case of an overdose of Alfacalcidol 2mg Drops, the primary concern is the potential for hypercalcemia, where an excessive amount of calcium builds up in the blood. Symptoms may include nausea, vomiting, constipation, confusion, and increased thirst and urination. Immediate medical attention is necessary to manage the overdose effectively. Treatment may involve rehydration, diuretics, and medications to control calcium levels, ensuring the patient's well-being and preventing potential complications.

In the case of a missed dose of Alfacalcidol 2mg Drops, it is recommended to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It's important to maintain a consistent dosing routine, but if you frequently miss doses, inform your healthcare provider for further guidance on managing your medication effectively.

To administer Alfacalcidol 2mg Drops, gently squeeze the recommended number of drops into the mouth or mix with a small amount of food or liquid as directed by your healthcare professional, ensuring the entire dose is consumed.

Following are the conditions or situations when Alfacalcidol 2mg Drops should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Alfacalcidol or any vitamin D compounds.
• Contraindicated in patients with high blood calcium levels (hypercalcemia) or high blood calcium in urine (hypercalciuria).
• Not recommended for patients with kidney stones or a history of kidney disease.
• Should not be used in individuals with evidence of vitamin D toxicity.
• Contraindicated in patients with a condition called hypervitaminosis D, where vitamin D levels are excessively high.
• Not suitable for those with impaired liver function or active liver disease.
• Should be avoided in patients with calcification in blood vessels or soft tissues.
• Do not use if there is a history of allergic reactions to any of the excipients in the drop formulation.

The side effects of Alfacalcidol 2mg Drops may include:

• Nausea and vomiting
• Headache
• Dizziness
• Weakness or fatigue
• Increased thirst and urination
• Muscle or joint pain
• Elevated calcium levels in the blood (hypercalcemia)
• Skin rash or itching

Following are the precautions and warnings for Alfacalcidol 2mg Drop:

• Do not use if you are allergic to Alfacalcidol or any other vitamin D compounds.
• Regular monitoring of calcium and phosphate levels in the blood is essential during treatment.
• Patients with kidney disease or those on dialysis should use with caution and under medical supervision.
• Not recommended for individuals with high blood calcium levels (hypercalcemia) or those with evidence of vitamin D toxicity.
• Elderly patients may be more sensitive to the effects and should be closely monitored for adverse reactions.
• Alfacalcidol may interact with other medications; inform your doctor about all the medicines you are taking.
• This medication should be used during pregnancy and breastfeeding only if clearly needed and under medical supervision.

Following are the drug interactions for Alfacalcidol 2mg Drop:

• Concomitant use with other vitamin D analogs or calcium supplements can lead to hypercalcemia, requiring close monitoring of calcium levels.
• Thiazide diuretics may enhance the effect of alfacalcidol, increasing the risk of hypercalcemia and the need for dosage adjustments.
• Anticonvulsants like phenobarbital and phenytoin can induce metabolism, reducing the effectiveness of alfacalcidol.
• Corticosteroids may interfere with vitamin D metabolism, necessitating increased alfacalcidol doses to maintain therapeutic effects.
• Antacids containing magnesium can decrease the absorption of alfacalcidol, reducing its effectiveness.
• Cholestyramine and colestipol can bind to alfacalcidol in the intestine, preventing its absorption and reducing its therapeutic effect.
• The use of digoxin with alfacalcidol may require close monitoring of digoxin levels as alfacalcidol can increase serum calcium, potentially affecting digoxin sensitivity.

Following are the food interactions for Alfacalcidol 2mg Drop:

• Alfacalcidol absorption can be affected by high-fiber diets, as fiber may bind to the drug and reduce its absorption. Avoid excessive fiber intake during treatment.
• Avoid consuming calcium-rich foods like milk, cheese, and calcium-fortified juices immediately after taking Alfacalcidol, as they can interfere with its absorption. Maintain a calcium-restricted diet as advised by your doctor.
• Vitamin D-fortified foods, such as some dairy products and cereals, should be consumed in moderation as they can alter the effects of Alfacalcidol. Follow your healthcare provider's guidelines.
• Grapefruit and grapefruit juice should be avoided as they may affect the metabolism of Alfacalcidol, potentially leading to increased drug levels in the body.
• Alcohol may not directly interact with Alfacalcidol, but it can increase the risk of dehydration and kidney problems, especially in individuals with kidney issues.
• Maintain a consistent diet, and avoid drastic changes in food intake, as they may influence the absorption and effectiveness of Alfacalcidol.
• Always consult your healthcare provider for personalized dietary recommendations during Alfacalcidol therapy.
• Ensure you stay well-hydrated during treatment, unless otherwise advised by your doctor.

Alfacalcidol 2mg Drops should be stored in a cool, dry place, preferably at room temperature between 15-25°C (59-77°F). Protect the medication from excessive heat, direct sunlight, and moisture. Keep the bottle tightly sealed when not in use to maintain its integrity. It is crucial to discard any unused or expired medication responsibly. Do not pour it down the sink or toilet; instead, seek guidance from a pharmacist or healthcare professional for safe disposal options. Ensure that the medicine is stored in a secure location, out of the reach of children and pets, to prevent accidental ingestion.

Following are the quick tips for Alfacalcidol 2mg Drop:

• Store the drops in a cool, dry place away from direct sunlight and moisture.
• Ensure the dropper is clean and uncontaminated before each use.
• Administer the prescribed number of drops accurately, following your doctor's instructions.
• Allow the drops to absorb into the mouth for better effectiveness.
• Do not mix the drops with other medications unless advised by your doctor.
• Inform your doctor about all the medicines you are taking to avoid potential drug interactions.
• Regularly monitor your vitamin D and calcium levels while using this medication.