Onita (2g) 7 Sachets

Strontium ranelate's primary mechanism of action involves its dual effect on bone remodeling. It selectively binds to bone mineral, particularly at sites of active bone remodeling. Strontium ranelate stimulates osteoblast activity, promoting bone formation. It increases the number and activity of osteoblasts, leading to the synthesis and deposition of new bone matrix. Simultaneously, it inhibits osteoclast-mediated bone resorption by reducing osteoclast differentiation and activity. This dual action results in an overall increase in bone mineral density, improving bone strength and reducing the risk of fractures. Strontium ranelate's unique ability to target both bone formation and resorption processes contributes to its effectiveness in treating osteoporosis and other bone-related disorders.

Strontium Ranelate Sachet:

Powder

The following are the uses of Strontium Ranelate Sachet:

• Used for treating osteoporosis in postmenopausal women and in men to reduce the risk of fractures.
• Used for improving bone density and strength by increasing bone formation and reducing bone loss.
• Used for slowing down the progression of osteoporosis and improving overall bone health.
• Used for alleviating back pain and reducing the risk of spinal fractures.
• Used for enhancing mobility and overall quality of life in individuals with osteoporosis.
• Used for managing bone health in individuals with low bone density or a history of fractures.
• Used for supporting bone healing and recovery after a fracture.

To be taken as per doctor's prescription

In the case of an overdose of Strontium Ranelate Sachet, it is important to remain calm and take appropriate action. Contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the severity of the overdose. Common symptoms may include nausea, vomiting, and abdominal pain. Treatment options could involve monitoring, supportive care, and managing any adverse effects to ensure the patient's well-being.

In the case of a missed dose of Strontium Ranelate Sachet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for advice on how to safely adjust your dosing schedule and ensure the medication's effectiveness.

To use Strontium Ranelate Sachet, empty the contents of the sachet into a glass of water, stir well until completely dissolved, and drink the entire mixture immediately, preferably in the morning on an empty stomach, as directed by your healthcare professional.

Strontium ranelate sachet should not be used in the following conditions:

• Hypersensitivity or allergy to strontium ranelate or any other components of the sachet.
• Severe renal impairment or chronic kidney disease, as strontium ranelate may worsen kidney function.
• History of venous or arterial thromboembolic events, such as deep vein thrombosis, pulmonary embolism, or stroke.
• Pregnancy, as strontium ranelate may harm the fetus.
• Breastfeeding, as it is not recommended for use during lactation.
• Severe uncontrolled heart failure.
• Children or adolescents under 18 years of age, as safety and efficacy have not been established in this age group.

The side effects of Strontium Ranelate Sachet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Abdominal pain
• Dizziness or lightheadedness
• Skin rashes or itching
• Swelling of the face, lips, or tongue
• Allergic reactions
• Joint pain or stiffness

Following are the precautions and warnings for Strontium Ranelate Sachet:

• This medication is intended for oral use only. Do not apply it to the skin or eyes, and do not inhale the powder.
• Patients with a history of hypersensitivity or allergic reactions to strontium ranelate or any of its excipients should not take this medication.
• Strontium Ranelate Sachet should be used with caution in patients with a history of blood clots, as it may increase the risk of venous thromboembolism.
• Regular monitoring of kidney function is necessary during treatment, especially in elderly patients and those with pre-existing kidney issues.
• Patients should be advised to maintain adequate hydration and to report any symptoms of kidney problems.
• This medication may cause dizziness or drowsiness. Patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Strontium Ranelate Sachet is not recommended for use in children and adolescents under 18 years of age due to insufficient data on safety and efficacy.
• Women of childbearing potential should use effective contraception while taking this medication and for at least two years after stopping treatment.

Following are the drug interactions for Strontium Ranelate Sachet:

• Thiazide diuretics may enhance the absorption of strontium ranelate, potentially increasing the risk of strontium-related side effects.
• Strontium ranelate can reduce the absorption of tetracycline antibiotics, leading to decreased effectiveness of these antibiotics. Separate doses by at least 2 hours.
• The absorption of strontium ranelate may be decreased by calcium supplements, dairy products, and antacids containing calcium or magnesium. Take strontium ranelate at least 2 hours before or after these products.
• Bisphosphonates, when taken orally, may compete with strontium ranelate for absorption, reducing the effectiveness of both drugs. Separate doses by at least 2 hours.
• Certain medications like phenytoin, phenobarbital, and carbamazepine can increase the metabolism of strontium ranelate, possibly reducing its effectiveness.
• Strontium ranelate may interact with digoxin, increasing serum digoxin levels. Monitor digoxin levels and adjust the dose if necessary.
• Concomitant use of corticosteroids may increase the risk of adverse gastrointestinal effects and potentially reduce the effectiveness of strontium ranelate.

Following are the food interactions to consider with Strontium Ranelate Sachet:

• Avoid excessive consumption of calcium-rich foods like dairy products, spinach, and broccoli, as Strontium can compete with calcium for absorption, potentially reducing the effectiveness of the medication.
• Ensure an adequate intake of Vitamin D and maintain a balanced diet, as it aids in the absorption of Strontium and promotes overall bone health.
• Avoid high-fiber foods such as whole grains, legumes, and certain fruits and vegetables immediately before or after taking Strontium Ranelate, as fiber may interfere with the absorption of the medication.
• Maintain a consistent fluid intake to support overall hydration and ensure the effective dissolution of the sachet content.
• Limit the intake of carbonated beverages as they may decrease bone mineral density, potentially counteracting the benefits of Strontium Ranelate.
• Avoid excessive caffeine consumption, as it may interfere with calcium absorption and potentially reduce the medication's effectiveness.
• Consult a healthcare professional for personalized dietary advice, especially if you have a history of gastrointestinal issues or other medical conditions that may affect nutrient absorption.

Strontium ranelate sachets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. Keep the sachets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures, so avoid storage in hot or humid environments like bathrooms or near kitchens. Always check the expiration date, and if the sachet has passed its expiry, do not use it and dispose of it appropriately. For proper disposal methods, consult your pharmacist or healthcare provider, and do not flush or pour the medication down the drain. Keep the sachets out of children's reach to prevent accidental consumption.

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Following are the quick tips for Strontium Ranelate Sachet:

• Mix the sachet contents thoroughly with water as directed by your doctor or pharmacist.
• Consume the entire mixture immediately after preparation for best results.
• Take the medication regularly and at the same time each day to maintain consistent blood levels.
• Ensure you drink plenty of fluids throughout the day to reduce the risk of side effects.
• Do not crush or chew the granules; swallow them directly with the water for effective absorption.
• If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose.
• Avoid taking a double dose to make up for a missed one, and continue your regular dosing schedule.