Opt-D (100,000IU) 2 Capsules

Cholecalciferol, also known as vitamin D3, has a specific mechanism of action. When administered, it enters the body and undergoes two hydroxylation reactions to become its active form, calcitriol. The first hydroxylation occurs in the liver, converting cholecalciferol to 25-hydroxyvitamin D (calcifediol). Subsequently, the kidneys perform the second hydroxylation, transforming calcifediol into 1,25-dihydroxyvitamin D (calcitriol). Calcitriol then binds to vitamin D receptors (VDRs) in various target cells, primarily in the intestines, bones, and kidneys. This binding activates specific genes that regulate calcium and phosphate metabolism. In the intestines, it enhances calcium and phosphate absorption, ensuring proper mineralization of bones. In bones, it promotes the release of calcium and phosphate into the bloodstream, maintaining calcium homeostasis. Moreover, cholecalciferol indirectly influences bone remodeling by promoting osteoclast differentiation and inhibiting osteoblast apoptosis.

Cholecalciferol 100,000iu

Vitamin D analog

Capsule

The following are the uses of Cholecalciferol 100,000iu Capsule:

• Used for treating and preventing Vitamin D deficiency, ensuring healthy bone development and preventing conditions like rickets or osteomalacia.
• Used to promote calcium absorption, which is crucial for maintaining strong and healthy bones.
• Used in the management of hypoparathyroidism, a condition where the body produces too little parathyroid hormone, affecting calcium and phosphorus levels.
• Used for managing conditions like renal osteodystrophy, a bone disorder associated with kidney disease, by regulating calcium and phosphorus metabolism.
• Used for supporting immune system function, as Vitamin D plays a role in immune response and overall health.
• Used in the treatment of psoriasis, a skin condition, by regulating skin cell growth and reducing inflammation.
• Used to improve muscle strength and overall physical performance, especially in individuals with Vitamin D deficiency.
• Used as a supplement for individuals with limited sun exposure or malabsorption issues, ensuring they receive adequate Vitamin D.

The following dosage regimen is to be followed:

• Adults

The Recommended Dietary Allowance for adults is 600 IU daily

• Geriatric

The RDA for people 70 years or above is 800 IU daily

• Children

To be used as per doctor's recommendation

In the case of an overdose of Cholecalciferol 100,000 IU capsules, individuals may experience symptoms such as nausea, vomiting, and extreme thirst. High calcium levels in the blood can lead to potential complications, including kidney damage and abnormal heart rhythms. Prompt medical intervention is necessary, and individuals should seek emergency care if they suspect an overdose. Treatment may involve supportive care and measures to reduce calcium levels, ensuring the patient's well-being and preventing long-term health consequences.

In the case of a missed dose of Cholecalciferol 100,000 IU Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking extra doses to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you remember to take your medication as prescribed.

To take Cholecalciferol 100,000 IU capsules, swallow the capsule whole with a glass of water, preferably with a meal or as directed by your healthcare professional, following the prescribed dosage schedule provided by your doctor.

Here is a list of situations or conditions when Cholecalciferol 100,000 IU Capsule should not be taken:

• Should not be used in individuals with a known hypersensitivity or allergy to Cholecalciferol (Vitamin D3) or any of the excipients in the capsule.
• Contraindicated in individuals with hypervitaminosis D, a condition where there are high levels of vitamin D in the body.
• Not recommended for patients with hypercalcemia, which is elevated calcium levels in the blood.
• Should not be used in patients with hypercalciuria, a condition of high levels of calcium in the urine.
• Contraindicated in individuals with conditions that cause calcium to be deposited in soft tissues, such as lungs or kidneys (metastatic calcification).
• Not suitable for patients with kidney stones or a history of kidney stones.
• Should be avoided in patients with sarcoidosis, a condition of abnormal collections of inflammatory cells in the body.
• Not recommended for individuals with primary hyperparathyroidism, a condition of overactive parathyroid glands.

The side effects of Cholecalciferol 100,000 IU Capsule may include:

• Nausea and vomiting
• Weakness and fatigue
• Dry mouth
• Loss of appetite
• Constipation
• Metallic taste in the mouth
• Muscle or bone pain
• Increased calcium levels in the blood (hypercalcemia)

Following are the precautions and warnings for Cholecalciferol 100,000 IU Capsule:

• Do not exceed the recommended dosage; taking more than prescribed can lead to vitamin D toxicity.
• Regular monitoring of calcium and vitamin D levels is essential during prolonged treatment.
• Patients with a history of kidney stones or kidney disease should use this medication with caution.
• Individuals with hypercalcemia (high calcium levels) should not take this medication.
• Cholecalciferol capsules should be swallowed whole; do not chew or crush them.
• Not recommended for individuals with a known allergy to vitamin D or any of its components.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it can affect fetal and infant development.
• Patients on a controlled diet or with specific medical conditions should seek medical advice regarding the use of this supplement.

Following are the drug interactions for Cholecalciferol 100,000 IU Capsule:

• Thiazide diuretics and calcium-channel blockers may reduce the absorption of Cholecalciferol, leading to decreased vitamin D levels.
• Anticonvulsants such as phenytoin and phenobarbital can accelerate the metabolism of vitamin D, reducing its effectiveness.
• Cholestyramine and colestipol can bind to Cholecalciferol in the digestive tract, preventing its absorption.
• Orlistat, a weight-loss medication, may decrease the absorption of fat-soluble vitamins like vitamin D.
• Corticosteroids like prednisone can increase the breakdown of bone and interfere with vitamin D metabolism, potentially leading to lower calcium levels.
• Aluminum-containing antacids can reduce the absorption of vitamin D, especially when taken together.
• Certain medications used to treat HIV/AIDS, such as protease inhibitors, may increase the metabolism of vitamin D, requiring higher doses to maintain adequate levels.

Following are the food interactions for Cholecalciferol 100,000 IU Capsule:

• Consuming high-fat meals while taking this medication may increase vitamin D absorption. Consider consistent meal patterns for optimal absorption.
• Certain types of fish, like salmon and mackerel, as well as fish liver oils, are rich in vitamin D. Monitor vitamin D levels if consuming these regularly.
• Fortified foods like milk, orange juice, and cereals often contain added vitamin D. Check labels to ensure you don't exceed recommended limits.
• Egg yolks contain a notable amount of vitamin D. Be mindful of your intake if consuming multiple eggs daily.
• While sunlight is a natural source of vitamin D, excessive sun exposure without protection can lead to sunburn and skin damage.
• Some mushrooms, especially those exposed to UV light, can be a source of vitamin D. Include them in moderation in your diet.
• Avoid excessive intake of calcium-rich foods like dairy products and calcium-fortified foods, as vitamin D increases calcium absorption.

Cholecalciferol 100,000iu Capsules should be stored in a cool, dry area, ideally between 68-77°F (20-25°C). Keep the capsules in their original container, tightly sealed, to maintain their integrity and protect them from light and moisture. It's crucial to store them away from heat and direct sunlight, as extreme temperatures can impact their effectiveness. Always check the expiration date, and if the capsules are past their prime, do not use them and dispose of them appropriately. For safe disposal, avoid flushing them down the toilet or pouring them into any water source. Instead, consult a pharmacist or healthcare professional for guidance on proper disposal methods. Ensure the capsules are kept out of children's reach to prevent accidental consumption.

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Following are the quick tips for Cholecalciferol 100,000iu Capsule:

• Take the capsule as directed by your doctor, typically once a week or as advised.
• Swallow the capsule whole with a full glass of water, preferably with a meal.
• Maintain a consistent schedule for taking the medication for best results.
• Ensure you complete the full course as prescribed, even if you feel better.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
• Do not take extra doses to make up for a missed one; stick to the prescribed dosage.
• Inform your doctor if you have any underlying medical conditions or are taking other medications.