Ovafin (50mg) 10 Tablets

Clomiphene is a selective estrogen receptor modulator (SERM) that primarily works by blocking estrogen receptors in the hypothalamus, which is an essential part of the brain responsible for regulating reproductive hormones. By inhibiting estrogen's action at the hypothalamus, Clomiphene disrupts the negative feedback mechanism, which leads to an increase in the secretion of gonadotropins (LH and FSH) from the pituitary gland. These hormones stimulate the ovaries, promoting follicular maturation and ovulation. This process is useful for women who have ovulatory dysfunction, including those with polycystic ovary syndrome (PCOS) or unexplained infertility.

Clomiphene 50mg

Selective Estrogen Receptor Modulators (SERMs)

Tablet

The following are the uses of Clomiphene 50mg Tablet:

• Treatment of female infertility due to anovulation.
• Induction of ovulation in women with polycystic ovary syndrome (PCOS).
• Treatment of unexplained infertility in women.
• Used in combination with other fertility treatments to increase the chances of pregnancy.
• Can be used to regulate menstrual cycles and restore ovulation in women with irregular periods caused by ovulatory dysfunction.

Following are the doses of Clomiphene 50mg Tablet:

• The usual dose for females with infertility is 50mg once daily for 5 days, starting on the 5th day of the menstrual cycle.
• If ovulation does not occur after one cycle, the dose may be increased to 100mg for the next cycle, as directed by the healthcare provider.
• If ovulation does not occur after three cycles at the maximum dose of 100mg, alternative treatments may be considered.
• For women undergoing fertility treatments or with specific conditions, the dose may vary based on individual circumstances and should be followed exactly as prescribed by the healthcare provider.

In case of an overdose of Clomiphene 50mg Tablet, immediate medical attention should be sought. Symptoms of overdose may include visual disturbances, abdominal discomfort, nausea, or vomiting. If you suspect an overdose, it is crucial not to induce vomiting or take any other actions without consulting a healthcare provider.

If you miss a dose of Clomiphene 50mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for the missed dose, as this could increase the risk of side effects.

To use Clomiphene 50mg Tablet, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it is taken once daily for 5 days, starting on the 5th day of the menstrual cycle. Swallow the tablet whole with a glass of water, without chewing or crushing it. It is important to take the medication at the same time each day to help you remember and maintain consistent levels in your body.

Following are the situations when Clomiphene 50mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Clomiphene or any of its components.
• Contraindicated in women who are pregnant.
• Should not be used in individuals with uncontrolled thyroid or adrenal disorders.
• Not recommended for women with ovarian cysts, except for polycystic ovary syndrome (PCOS).
• Should not be used in patients with liver disease or abnormal liver function tests.
• Contraindicated in women with uterine bleeding of unknown cause.
• Not suitable for women who have a history of pituitary gland disorders.

The side effects of Clomiphene 50mg Tablet may include:

• Hot flashes
• Abdominal discomfort or bloating
• Nausea
• Headache
• Mood swings
• Breast tenderness
• Visual disturbances (e.g., blurred vision)
• Ovarian cyst formation
• Multiple pregnancies (increased chance of twins or more)

Following are the precautions and warnings for Clomiphene 50mg Tablet:

• Should not be used in individuals with a known allergy to Clomiphene or any of its ingredients.
• Contraindicated in patients with liver disease, as it may exacerbate liver dysfunction.
• Not recommended for use in women with primary ovarian failure or non-functional gonads.
• Caution is advised in women with a history of ovarian cysts, as Clomiphene may cause ovarian enlargement or cyst formation.
• Patients with thyroid or adrenal gland dysfunction should use Clomiphene under close supervision, as the medication may affect hormone levels.
• It should be used with caution in women with a history of endometrial disorders, as Clomiphene may increase the risk of endometrial hyperplasia.
• Not recommended for use during pregnancy. It is important to confirm pregnancy status before starting Clomiphene therapy.

Following are the drug interactions for Clomiphene 50mg Tablet:

• Concomitant use of Clomiphene with other hormonal treatments, such as estrogen or progesterone, can increase the risk of adverse effects and should be avoided unless prescribed by a healthcare provider.
• The use of Clomiphene with drugs that affect liver enzymes, such as carbamazepine or phenytoin, may alter the metabolism of Clomiphene and reduce its effectiveness.
• Caution is advised when combining Clomiphene with medications that can affect the pituitary-gonadal axis, such as corticosteroids, as they may interfere with the medication's action.
• Clomiphene may interact with certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), affecting its hormonal effects. Always consult your healthcare provider before using these medications together.

Following are the food interactions for Clomiphene 50mg Tablet:

• Grapefruit or grapefruit juice may interact with Clomiphene and potentially alter its effectiveness. It's best to avoid consuming grapefruit products while taking Clomiphene.
• Alcohol consumption should be minimized or avoided, as it can interfere with the body's hormonal balance and may affect the medication's effectiveness.
• A high-fat meal may delay the absorption of Clomiphene, so it's recommended to take the tablet on an empty stomach or with a light meal for optimal absorption.

Clomiphene 50mg tablets should be stored at room temperature, away from direct light, heat, and moisture. It is recommended to keep the medication in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom, as excessive moisture can affect the stability of the medication. If the tablets are expired or no longer needed, they should be disposed of properly. Do not flush the medication down the toilet or throw it in the trash. Check with your pharmacist or healthcare provider for the proper disposal methods in your area.

Following are the quick tips for Clomiphene 50mg Tablet:

• Take Clomiphene exactly as prescribed by your healthcare provider for the best results.
• It is usually taken on specific days of your menstrual cycle, as advised by your doctor, to promote ovulation.
• Avoid taking Clomiphene for more than the prescribed number of cycles to reduce the risk of complications.
• Maintain regular follow-up appointments to monitor your response to treatment, including blood tests and ultrasounds.
• Inform your doctor if you experience any unusual symptoms such as visual disturbances, abdominal discomfort, or signs of ovarian hyperstimulation.