Pacific's Jack & Jill 120ml Syrup

Chlorpheniramine, an antihistamine, in the syrup/suspension formulation, acts by competitively blocking H1-receptor sites on effector cells, preventing histamine from binding. This action helps to reduce allergic responses and alleviate symptoms such as sneezing, itching, and runny nose. Dextromethorphan, a cough suppressant, works by acting centrally in the medulla to elevate the cough threshold, thereby reducing the frequency and intensity of coughing.

Chlorpheniramine, Dextromethorphan

Antihistamine, Antitussive

Suspension

The following are the uses of Chlorpheniramine, Dextromethorphan Syrup/Suspension:

• Used for temporarily relieving symptoms of the common cold, such as sneezing, runny nose, and cough.
• Used for treating allergic rhinitis and easing symptoms like itching, watery eyes, and nasal congestion.
• Used for suppressing coughs, particularly those caused by minor throat and airway irritation.
• Used to provide relief from itching and rashes associated with various skin allergies.
• Used for helping individuals with insomnia by promoting sleepiness and relaxation.
• Used to reduce symptoms of motion sickness, including nausea and vomiting.
• Used for managing certain types of chronic coughs, under medical supervision.

To be administered as per instruction of a healthcare practitioner

In the case of an overdose of Chlorpheniramine, Dextromethorphan Syrup/Suspension, symptoms may include severe drowsiness, confusion, rapid heartbeat, and difficulty breathing. Immediate medical attention is required as these overdoses can lead to serious health complications. Quick action should be taken to induce vomiting or seek emergency medical care to prevent potential harm to the respiratory and cardiovascular systems. Timely intervention is crucial to mitigate the risks associated with this medication overdose.

In the case of a missed dose of Chlorpheniramine, Dextromethorphan Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. It is important to adhere to the prescribed dosage and consult a healthcare professional if you have any concerns.

To take Chlorpheniramine, Dextromethorphan Syrup/Suspension, measure the prescribed dose using a measuring cup or oral syringe, then swallow the syrup directly or mix it with a small amount of water or juice and take it orally, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Chlorpheniramine, Dextromethorphan Syrup/Suspension should not be used:

• Must not be administered to individuals with a known allergy to Chlorpheniramine, Dextromethorphan, or any of the excipients in the formulation.
• Contraindicated in patients with a history of hypersensitivity reactions to antihistamines or antitussives.
• Not suitable for patients with narrow-angle glaucoma, as it can worsen the condition.
• Should be avoided in individuals with chronic respiratory conditions such as asthma, chronic bronchitis, or severe respiratory disease, as it may cause respiratory depression.
• Must not be used in patients with severe liver impairment, as it can lead to an accumulation of the drug and its metabolites.
• Contraindicated in patients with a history of seizures or those taking medications that lower the seizure threshold.
• Not recommended for individuals with a history of gastrointestinal obstruction or those at risk of pyloric stenosis.
• Should not be used in patients who have taken MAO inhibitors within the last 14 days, as it may cause a severe drug interaction.
• Not suitable for children below 2 years of age due to the potential risk of serious side effects.
• Must be avoided in patients with a history of urinary retention or an enlarged prostate, as it can worsen these conditions.

The side effects of Chlorpheniramine, Dextromethorphan Syrup/Suspension may include:

• Drowsiness or sleepiness
• Dry mouth
• Blurred vision
• Constipation
• Nausea and vomiting
• Dizziness
• Restlessness or excitability (more common in children)
• Difficulty in urination

Following are the precautions and warnings for Chlorpheniramine, Dextromethorphan Syrup/Suspension:

• Avoid using this medication if you are allergic to any of its ingredients or have a known sensitivity to antihistamines or cough suppressants.
• This medication may cause drowsiness and dizziness, so refrain from driving, operating heavy machinery, or engaging in activities that require mental alertness until you know how it affects you.
• Alcohol consumption should be avoided as it can increase the risk of side effects and drowsiness.
• Do not exceed the recommended dosage, as it may lead to serious side effects, including rapid heartbeat, blurred vision, and difficulty urinating.
• Patients with certain medical conditions such as glaucoma, asthma, high blood pressure, heart disease, liver disease, or difficulty urinating should use this medication with caution and under medical supervision.
• Elderly patients may be more sensitive to the side effects of this medication, especially dizziness and drowsiness.
• Consult a healthcare professional before use if you are pregnant, planning to become pregnant, or breastfeeding, as the effects on the fetus and infant are not fully established.
• Keep this medication out of reach of children. In case of accidental ingestion, seek immediate medical attention.

Following are the drug interactions for Chlorpheniramine, Dextromethorphan Syrup/Suspension:

• Alcohol or other central nervous system (CNS) depressants can increase drowsiness and other side effects when taken with this medication.
• Monoamine oxidase inhibitors (MAOIs) should not be used concurrently due to the risk of serious reactions.
• Medications metabolized by the liver, such as certain antidepressants and antipsychotics, may have increased blood levels when taken with this syrup.
• Chlorpheniramine may decrease the effectiveness of glaucoma eye drops or other medications used to treat glaucoma.
• Dextromethorphan can interact with certain antidepressants (e.g., SSRIs, SNRIs) and increase the risk of serotonin syndrome.
• The syrup may reduce the effectiveness of antimuscarinic medications used to treat conditions like overactive bladder.
• Caution is advised when using with medications that affect heart rhythm, as it may increase the risk of arrhythmias.

Following are the food interactions for Chlorpheniramine, Dextromethorphan Syrup/Suspension:

• Grapefruit and grapefruit juice should be avoided as they may inhibit the CYP450 enzyme system, potentially increasing the concentration of Chlorpheniramine in the blood and leading to prolonged sedation.
• Alcohol consumption should be avoided as it can increase the sedative effects of Chlorpheniramine, causing excessive drowsiness and impaired coordination.
• Caffeine-containing beverages like coffee and energy drinks should be limited as they can counteract the sedating effects of Chlorpheniramine, potentially reducing its effectiveness in relieving allergy symptoms.
• Dairy products like milk and cheese may slow Chlorpheniramine absorption, but this effect is generally not significant and does not require timing adjustments between meals and medication.
• A high-fat meal may slightly delay the absorption of Dextromethorphan, but it is unlikely to impact the overall effectiveness of the medication.
• Avoid eating large meals after taking the syrup/suspension to prevent delayed absorption and potential stomach discomfort.
• Generally, the syrup/suspension can be taken with or without food, but it's best to follow the instructions provided by your healthcare professional.
• No significant food interactions are known to affect the safety or efficacy of Dextromethorphan in the syrup/suspension.

Chlorpheniramine, Dextromethorphan Syrup/Suspension should be stored in a secure location, preferably in a locked medicine cabinet, at room temperature, away from excessive heat, direct sunlight, and moisture. Keep the bottle tightly sealed to maintain its integrity and prevent contamination. When disposing of the medication, do not pour it down the sink or flush it down the toilet. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for guidance on safe disposal practices. It is crucial to keep this medication out of the reach of children and pets to prevent accidental ingestion, as it can be harmful if consumed without proper medical supervision. Proper storage and disposal practices are essential to ensure the safety and effectiveness of the medication.

Yes

Following are the quick tips for Chlorpheniramine, Dextromethorphan Syrup/Suspension:

• Always follow your healthcare provider's instructions for dosage and usage.
• Shake the bottle vigorously to ensure a well-mixed suspension.
• Administer the syrup with a full glass of water for better effectiveness.
• Maintain a consistent schedule for taking the medication daily.
• Consider taking it with food to reduce potential stomach irritation.
• Store the medication safely, away from children's access.
• Do not mix with other medications unless advised by your healthcare professional.
• Consult your doctor if you have any pre-existing medical conditions or are taking other medications.