Peridone (5mg/5ml) 120ml Suspension

Domperidone is a peripheral dopamine D2 receptor antagonist that works primarily in the gastrointestinal (GI) tract and the brain. It acts by blocking dopamine receptors in the stomach and upper part of the small intestine, which helps to promote gastric motility and accelerates gastric emptying. By inhibiting dopamine receptors in the chemoreceptor trigger zone (CTZ) in the brain, Domperidone also reduces nausea and vomiting. Unlike other antiemetic medications, Domperidone does not cross the blood-brain barrier to a significant extent, thus it minimizes central nervous system side effects, such as sedation.

Domperidone

Dopamine Antagonists

Syrup/Suspension

The following are the uses of Domperidone Syrup/Suspension:

• Treatment of nausea and vomiting caused by various conditions, including medication side effects and gastrointestinal disorders.
• Relief of symptoms associated with delayed gastric emptying, such as bloating, fullness, and discomfort.
• Management of gastroesophageal reflux disease (GERD) by improving gastric motility.
• Treatment of nausea and vomiting associated with conditions like Parkinson’s disease, where dopamine antagonists are needed.
• Used as an adjunct therapy for promoting lactation in women who have difficulty breastfeeding due to insufficient milk production.

The following are the uses of Domperidone Syrup/Suspension:

• Treatment of nausea and vomiting caused by various conditions, including medication side effects and gastrointestinal disorders.
• Relief of symptoms associated with delayed gastric emptying, such as bloating, fullness, and discomfort.
• Management of gastroesophageal reflux disease (GERD) by improving gastric motility.
• Treatment of nausea and vomiting associated with conditions like Parkinson’s disease, where dopamine antagonists are needed.
• Used as an adjunct therapy for promoting lactation in women who have difficulty breastfeeding due to insufficient milk production.

In case of an overdose of Domperidone Syrup/Suspension, immediate medical attention should be sought. Symptoms of overdose may include drowsiness, agitation, and increased heart rate. If you suspect an overdose, it is important not to induce vomiting or take any other actions without consulting a healthcare provider. In some cases, medical professionals may administer activated charcoal or other treatments to manage the overdose.

If you miss a dose of Domperidone Syrup/Suspension, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for the missed dose, as this could increase the risk of side effects.

To use Domperidone Syrup/Suspension, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it should be taken before meals to maximize effectiveness. Shake the bottle well before each use. Use the provided measuring spoon or syringe to ensure you take the correct dose.

Following are the situations when Domperidone Syrup/Suspension should not be used:

• Should not be used in individuals with a known allergy to Domperidone or any of its components.
• Contraindicated in patients with a history of heart conditions such as QT prolongation, arrhythmias, or heart failure.
• Should not be used in individuals with gastrointestinal bleeding, mechanical obstruction, or perforation.
• Contraindicated in patients with liver impairment or severe renal disease.
• Not recommended for use in children under 12 years of age unless specifically prescribed by a healthcare provider.

The side effects of Domperidone Syrup/Suspension may include:

• Dry mouth
• Headache
• Dizziness
• Abdominal discomfort or pain
• Diarrhea
• Fatigue
• Rash
• Increased prolactin levels leading to potential breast enlargement or tenderness

Following are the precautions and warnings for Domperidone Syrup/Suspension:

• Should not be used in individuals with a known allergy to Domperidone or any of the components of the syrup.
• Caution is advised in patients with heart conditions, as Domperidone can affect the heart's electrical conduction and may increase the risk of arrhythmias.
• Should not be used in individuals with a history of gastrointestinal bleeding or obstruction.
• Use with caution in patients with liver or kidney impairment, as dosage adjustments may be necessary.
• Not recommended for use during pregnancy unless the potential benefit outweighs the potential risk, as Domperidone can pass into breast milk.
• Avoid long-term use unless directed by a healthcare provider due to the risk of developing side effects like prolactin-related effects.

Following are the drug interactions for Domperidone Syrup/Suspension:

• Concomitant use with drugs that prolong the QT interval (e.g., certain antiarrhythmic agents, antipsychotics, or tricyclic antidepressants) may increase the risk of serious cardiac events.
• Domperidone may interact with CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir), which can increase Domperidone levels and the risk of side effects, especially on the heart.
• Use caution when taken with drugs that increase the level of prolactin (e.g., certain antipsychotic drugs), as this may amplify the effects of Domperidone.
• Antacids or medications that decrease gastric acidity may interfere with Domperidone's absorption, reducing its effectiveness.
• Co-administration with other medications that affect the gastrointestinal motility may alter the effects of Domperidone.

Following are the food interactions for Domperidone Syrup/Suspension:

• Grapefruit and grapefruit juice should be avoided as they may increase the levels of Domperidone in the blood due to the inhibition of the enzyme CYP3A4, which can increase the risk of side effects, especially cardiac issues.
• Alcohol should be avoided while using Domperidone, as it can increase the sedative effects and increase the risk of side effects such as dizziness and drowsiness.
• There are no significant food interactions that directly affect Domperidone’s absorption or effectiveness, but it's always best to follow the instructions provided by your healthcare provider.

Domperidone Syrup/Suspension should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is important to keep the medication tightly closed in its original container to protect it from contamination. Avoid storing it in the bathroom or near heat sources such as stoves or radiators, as temperature extremes can affect the stability of the medication. Always check the expiration date on the packaging before use, and dispose of any unused or expired syrup properly. Do not flush it down the toilet or pour it into a drain. Instead, consult your pharmacist or healthcare provider for proper disposal methods. Keeping medication out of reach of children is also essential to prevent accidental ingestion.

Following are the quick tips for Domperidone Syrup/Suspension:

• Use Domperidone syrup as prescribed by your healthcare provider for the best results.
• Measure the dose accurately using the provided measuring cup or spoon to ensure proper dosing.
• Shake the bottle well before each use to ensure the syrup is evenly mixed.
• Take the medication before meals for optimal effectiveness, unless otherwise directed by your healthcare provider.
• If you experience any side effects or feel unwell, contact your healthcare provider immediately for guidance.
• Keep the syrup out of reach of children to prevent accidental ingestion.