Plasaline (0.9%) 100ml Infusion

Sodium Chloride injection works by replenishing and restoring the body's fluid and electrolyte balance. When administered intravenously, it provides a source of water and essential electrolytes, primarily sodium (Na+) and chloride (Cl-) ions. These ions are crucial for maintaining proper cellular function, nerve impulse transmission, and muscle contraction. The injection helps to correct dehydration, replace fluid losses, and prevent or treat electrolyte imbalances. By providing the necessary solutes, Sodium Chloride injection helps to maintain osmotic pressure, regulate acid-base balance, and support the distribution of fluids between the intracellular and extracellular compartments. This mechanism ensures that vital organs and tissues receive adequate hydration and electrolyte support, thereby promoting overall physiological homeostasis.

Sodium chloride injection is an isotonic solution.

injection

The following are the uses of Sodium chloride injection:

• Used for replenishing body fluids and electrolytes
• Used for treating dehydration
• Used for maintaining fluid and electrolyte balance during surgery, illness, or intensive care
• Used for correcting sodium and chloride deficiencies
• Used for emergency treatment of sodium channel blocker toxicity
• Used for preventing and treating low blood sodium levels (hyponatremia)
• Used for providing nutrition to patients unable to eat, in combination with other nutrients

In the case of an overdose of Sodium Chloride Injection, symptoms may include fluid overload, electrolyte imbalances, and increased blood pressure. This can lead to swelling, confusion, seizures, and in severe cases, coma. Prompt medical intervention is necessary to manage the symptoms, which may involve monitoring vital signs, providing diuretics to promote fluid excretion, and correcting electrolyte imbalances through intravenous fluids and medications.

In the case of a missed dose of Sodium Chloride injection, it is important to follow the healthcare provider's instructions. If you miss an injection, administer it as soon as you remember, unless it is almost time for the next dose. Do not double the dose to catch up. If you miss a dose and it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Always consult your healthcare provider if you have any concerns or questions about missed doses.

To administer the Sodium Chloride Injection, draw the prescribed dose into a syringe and inject it intravenously, ensuring the needle is properly inserted into the vein, and slowly push the plunger to deliver the medication as directed by your healthcare professional.

Following are the conditions or situations when Sodium chloride injection should not be used:

• Avoid using if you have a known allergy or hypersensitivity to sodium chloride or any of the excipients in the injection.
• Not recommended for patients with hypernatremia (high levels of sodium in the blood).
• Contraindicated in individuals with severe heart failure or conditions where fluid overload or volume expansion is a concern.
• Should not be used in patients with pulmonary edema (fluid in the lungs).
• Avoid in patients with kidney failure or severe renal impairment as sodium and fluid balance may be affected.
• Not suitable for individuals with a history of uncontrolled hypertension (high blood pressure).
• Do not use if the seal of the container is broken or the solution is discolored or contains particles.

The side effects of Sodium Chloride Injection may include:

• Pain, swelling, or redness at the injection site
• Irritation or inflammation of the vein (phlebitis)
• Thrombosis (blood clot formation)
• Hypernatremia (high sodium levels in the blood)
• Fluid overload, especially in patients with heart or kidney conditions
• Edema (swelling due to excess fluid retention)
• Confusion or disorientation
• Seizures in rare cases

Following are the precautions and warnings for Sodium Chloride Injection:

• Not for intravenous administration; use only as directed by a healthcare professional for the prescribed route.
• Do not use if the solution is cloudy or contains particles.
• Ensure accurate dosage measurement, especially in neonates and infants, to avoid overhydration or electrolyte imbalances.
• Monitor fluid balance and electrolyte levels, particularly in patients with cardiac or renal disease.
• Use with caution in patients with hypertension, as it may increase blood pressure.
• Do not use for continuous infusion without proper monitoring and medical supervision.
• Consult a doctor if symptoms persist or worsen during treatment.

Following are the drug interactions for Sodium Chloride Injection:

• Can cause hypernatremia when used with other sodium-containing medications.
• May decrease the efficacy of lithium, leading to potential toxicity.
• Use with potassium-sparing diuretics may result in hyperkalemia.
• May reduce the effectiveness of antihypertensive medications.
• Concurrent use with corticosteroids can increase the risk of fluid retention and edema.
• Calcium-containing solutions should be avoided to prevent calcium-sodium imbalances.
• Drugs affecting renal function may lead to altered sodium excretion and potential electrolyte imbalances.

Following are the food interactions for Sodium Chloride Injection:

• Avoid excessive intake of salty foods or high-sodium meals, as Sodium Chloride Injection already provides a significant amount of sodium.
• Ensure adequate fluid intake to balance the sodium intake, especially if you have kidney-related issues.
• Restrict foods high in potassium, as Sodium Chloride can affect potassium levels.
• Limit foods like cured meats, canned soups, and salty snacks, as they can contribute to sodium overload.
• Avoid excessive use of table salt or seasonings high in sodium.
• Maintain a balanced diet and follow any dietary restrictions advised by your healthcare professional.
• Consult a dietician or healthcare provider for personalized advice, especially if you have conditions like hypertension or kidney disease.

Sodium Chloride Injection should be stored in a controlled environment, preferably in a cool and dry place with a temperature between 68°F and 77°F (20°C and 25°C). Protect the injection from freezing as it may affect the solution's integrity. Ensure the injection is stored in its original packaging, tightly sealed, and away from direct sunlight and moisture to maintain its sterility. Always check the expiration date before use and dispose of any unused or opened vials according to local regulations and guidelines for pharmaceutical waste disposal. Do not reuse or re-sterilize the injection as it may pose health risks. Keep the medication out of children's reach to prevent accidental exposure or ingestion.

Following are the quick tips for Sodium Chloride Injection:

• Administer the injection as directed by your healthcare professional.
• Ensure the injection is at room temperature before use.
• Use a sterile syringe to withdraw the correct dose.
• Inject the solution slowly as instructed, usually into a vein or as prescribed.
• Do not mix with other medications unless directed by your doctor.
• Dispose of used needles and syringes safely in a puncture-proof container.
• If you experience any discomfort or irritation at the injection site, inform your healthcare provider.