Plavix (75mg) 28 Tablets

Platelet aggregation inhibitors such as Clopidogrel are essential medications for individuals with certain cardiovascular and peripheral vascular diseases. It works by blocking the action of ADP, a substance in the blood that causes the platelets to stop sticking together and decreases the chance of blood clots forming. This helps to reduce the risk of heart attacks or strokes in people with cardiovascular disease, and strokes in people with peripheral vascular disease. Clopidogrel is actually a prodrug, a substance that is metabolized in the body to form a drug with the desired action. It is converted to its active metabolite by the liver through the enzyme CYP2C19. This enzyme is therefore critical to the effectiveness of Clopidogrel, and factors that influence CYP2C19 activity can affect the individual response to clopidogrel.Because many factors can influence its activity, the activity of platelet aggregation inhibitors can vary greatly between individuals. As such, its use should always be optimized for each patient under the guidance of a trained healthcare professional.

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Antiplatelet Agent

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Reducing the risk of blood clots forming in hardened arteries of the heart found in patients who have had a stroke, heart attack, or heart surgery.
• Reducing the risk of sudden death or heart attack in certain people with heart disease.
• For patients with acute coronary syndrome, Clopidogrel 75 mg is usually prescribed along with acetylsalicylic acid (ASA) therapy to help prevent a heart attack or recurrent stroke.
• Clopidogrel 75 mg does not provide immediate relief of symptoms such as chest pain that are related to coronary artery disease.

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Peripheral vascular diseases 75 mg once daily.
• Cerebrovascular diseases Acute therapy 300 mg once, followed by 75 mg once daily. Chronic therapy 75 mg once daily
• Coronary artery diseases Acute coronary syndrome 300 mg once, followed by 75 mg once daily
• Percutaneous coronary intervention 75 mg once daily for 7 days prior to the procedure, and 75 mg once daily for up to 1 month after the procedure

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Overdosing on Clopidogrel 75mg can really hurt your health. Some of the symptoms you may encounter are bleeding or bruising and have difficulty breathing. It is crucial to seek medical attention ASAP if you suspect an overdose has happened.

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It is important to take clopidogrel as directed by your doctor or pharmacist. If you miss a dose, you should take it as soon as possible. However, if it is almost time for your next dose, it is best to skip the missed dose and continue on your regular schedule. Do not double up on clopidogrel to make up for the missed dose as this can lead to an overdose or adverse side effects. If you have any questions or concerns about missing a dose, be sure to speak with your doctor or pharmacist for further guidance.

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Before you take clopidogrel, be sure to inform your doctor of any allergies, health conditions, or medications you are currently taking. Clopidogrel can interact with other medications, so it is important to disclose all information regarding your medical history and any other substances you put into your body.

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Discerning instances where this medication may not be appropriate:

• Are allergic to clopidogrel or any of the other ingredients in this medication
• Have any active bleeding or bleeding disorder
• Have recently had a stroke or suffered a mini-stroke (TIA)
• Have recently undergone a coronary artery bypass graft (CABG) surgery
• Have serious liver disease
• Have thrombocytopenia (low platelet count)
• Have kidney disease or are on dialysis

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Unraveling the side effects lurking behind this medications are as follows:

• Bleeding problems
• Chest pain (angina) or heart attack (myocardial infarction)
• Fever
• Severe muscle pain
• Severe stomach pain or tenderness
• Swelling of the hands, ankles, or feet
• Bleeding complications such as gastrointestinal bleeding and stroke
• Feeling lightheaded or loss of consciousness (fainting)

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Here are some precautions and warnings patients should keep in mind:

• Patients with platelet disorders, bleeding disorders, or at increased risk for bleeding (e.g. recent trauma or surgery) should exercise caution.
• Those with lesions that have a propensity to bleed (e.g. gastrointestinal, intraocular) should be monitored closely.
• Patients with acute lower gastrointestinal bleeding or coronary artery stents must be carefully evaluated.
• Individuals with previous hypersensitivity or hematologic reactions to thienopyridine use (e.g. ticlopidine, prasugrel) should avoid use.
• CYP2C19 intermediate and poor metabolizers should be aware of altered drug metabolism.
• Patients undergoing CABG or other elective surgical procedures should notify their healthcare provider.
• It is recommended to temporarily discontinue use 5-7 days before elective surgery if the antiplatelet effect is not desirable.
• Caution is advised for patients with renal or moderate hepatic impairment.
• Elderly individuals should be monitored for potential adverse effects.
• Special care should be taken during pregnancy and lactation.

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Drug interactions with clopidogrel include:

• Anticoagulants (e.g., warfarin) (may increase the risk of bleeding- monitor INR closely)
• Other antiplatelet agents (e.g., aspirin) (additive effects on bleeding risk)
• Proton pump inhibitors (e.g., omeprazole) (may reduce clopidogrel's effectiveness by inhibiting its activation)
• CYP2C19 inhibitors (e.g., fluoxetine, ticlopidine) (may reduce clopidogrel effectiveness)
• CYP2C19 inducers (e.g., rifampin) (may increase clopidogrel metabolism but may affect therapeutic levels)
• Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen) (may increase the risk of gastrointestinal bleeding)
• Antidiabetic medications (e.g., metformin) (no significant interaction, but monitor for any unusual bleeding or glucose changes)
• Antihypertensives (e.g., lisinopril) (no significant interaction, but monitor blood pressure and bleeding risk)
• Herbal supplements (e.g., ginkgo biloba, garlic) (may increase bleeding risk)

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The food interactions that should be considered while using Clopidogrel are:

• Avoid alcohol as it can increase the risk of gastrointestinal bleeding and interact with the medication
• Avoid grapefruit as it can interfere with the medication's effectiveness
• High-fat meals may affect the absorption of the medication.

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Clopidogrel is a medication that is typically prescribed to those who have had a heart attack or who are at risk for serious blood clots. It is a generic medication with several brands, and it is typically taken once daily to reduce the risk of heart attack, stroke, and other issues related to the heart and blood vessels. This medication is a prescription drug and not available over the counter. Clopidogrel is a platelet aggregation inhibitor, meaning it helps prevent blood cells called platelets from clustering together to form a blood clot. It is important to take clopidogrel consistently in order to achieve the necessary level of blood thinning and prevention of clotting. This medication typically comes in tablet form and should be stored at room temperature in its original container, away from moisture, heat, and direct light. It is important to keep clopidogrel out of the sight and reach of children and pets, and to avoid storing it in the bathroom due to humidity. You should follow the instructions given by your doctor or pharmacist regarding timing and dosage, and any instructions regarding food and drink. If you have any questions or concerns about your clopidogrel prescription or its storage, you should consult your physician or pharmacist.

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