Provas (300mg/2ml) 5 Ampoule Injections

Paracetamol 300mg injection exerts its analgesic and antipyretic effects primarily through its active metabolite, which acts centrally by inhibiting the synthesis of prostaglandins. It selectively blocks cyclooxygenase (COX) enzymes in the central nervous system, reducing the production of prostaglandin E2, which is involved in pain signaling and the regulation of body temperature. This mechanism helps alleviate pain and reduce fever without directly affecting peripheral tissues or causing significant gastrointestinal side effects.

Analgesic, antipyretic

Injection

The following are the uses of Paracetamol 300mg injection:

• Used for relieving mild to moderate pain, such as headaches, toothaches, and post-surgical pain.
• Used for reducing fever and managing temperature in various conditions.
• Used for managing pain and discomfort associated with medical procedures.
• Used to provide pre-operative medication to reduce anxiety and pain.
• Used for the treatment of acute pain episodes in chronic pain management.
• Used to offer symptomatic relief in conditions like osteoarthritis and rheumatoid arthritis.
• Used for pain and fever relief in patients who cannot take oral medications.

In the case of an overdose of Paracetamol 300mg injection, prompt medical intervention is required. Symptoms may include nausea, abdominal pain, and potential liver damage. Treatment involves administering acetylcysteine, a specific antidote, to counteract the toxic effects. Medical professionals should closely monitor the patient's liver function and provide supportive care to manage symptoms and prevent further complications. Rapid response is crucial to minimize the risks associated with this type of overdose.

In the case of a missed dose of Paracetamol 300mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. For instance, if the prescribed frequency is every 6 hours, and a dose is missed, administer the injection as soon as you remember, then resume the regular dosing schedule. It is essential to maintain a consistent dosing routine for the medication's effectiveness.

To administer Paracetamol 300mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the entire contents of the vial into the muscle, ensuring the full dose is delivered.

Paracetamol 300mg injection should not be used in the following conditions:

• Hypersensitivity or allergy to paracetamol or any other components of the injection.
• Severe liver impairment or active liver disease, as paracetamol is metabolized in the liver.
• History of alcohol-related liver disease or heavy alcohol consumption.
• Severe renal impairment (kidney disease), as the medication may cause further renal damage.
• If the patient has a known history of hypersensitivity reactions to other analgesics or antipyretics.
• Patients with a history of or currently suffering from gastrointestinal disorders that may interfere with drug absorption or effectiveness.
• Pregnancy and breastfeeding should be avoided unless recommended by a healthcare provider, particularly in the first trimester.
• Not recommended for use in infants under 2 years of age without medical supervision.

The side effects of Paracetamol 300mg injection may include:

• Skin rash or itching
• Allergic reactions
• Nausea and vomiting
• Stomach pain
• Diarrhea
• Dizziness or lightheadedness
• Liver damage (in rare cases)
• Low blood pressure

Following are the precautions and warnings for Paracetamol 300mg Injection:

• Not recommended for long-term use; prolonged use may lead to liver damage.
• Patients with liver or kidney disease should use with caution and under medical supervision.
• Alcohol consumption should be avoided or limited as it may increase the risk of liver damage.
• Not suitable for patients with severe hepatic impairment or active liver disease.
• Elderly patients may require lower doses due to age-related kidney function decline.
• Should be used with caution in patients with severe malnutrition or anorexia.
• Discontinue use and seek medical attention if skin rash, itching, or other allergic reactions occur.

Following are the drug interactions for Paracetamol 300mg injection:

• Prolonged use with Metoclopramide or Domperidone may result in reduced effects of Paracetamol.
• Concomitant use with chloramphenicol may increase chloramphenicol levels.
• Can increase effects of oral anticoagulants like Warfarin, requiring reduced doses.
• May increase the risk of bleeding when used with antiplatelet drugs like Clopidogrel.
• Concomitant use with certain anticonvulsants like Phenytoin or Carbamazepine may reduce their effectiveness.
• Increases the risk of hepatotoxicity when used with other potentially hepatotoxic drugs.
• Alcohol consumption should be avoided as it may increase the risk of liver damage.

Following are the food interactions for Paracetamol 300mg injection:

• Paracetamol metabolism can be affected by chronic alcohol consumption, potentially leading to liver damage. Avoid alcohol consumption while using this medication.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the liver enzymes, affecting Paracetamol's metabolism.
• Avoid high-fat meals as they can delay the absorption of Paracetamol, resulting in reduced effectiveness.
• Caffeine-containing beverages like coffee and tea may increase the metabolism of Paracetamol, reducing its effectiveness.
• Consuming a balanced diet with adequate hydration is recommended to support overall health and medication effectiveness.
• Avoid excessive consumption of fatty foods as they may impact the distribution and elimination of Paracetamol.
• Certain herbal supplements, such as St. John's Wort, may induce liver enzymes, affecting Paracetamol's metabolism. Consult your healthcare provider before taking any herbal remedies.
• Always follow healthcare provider instructions regarding dietary restrictions and interactions specific to your medical condition.

Paracetamol 300mg injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. The injection vials should be kept intact and sealed until use to maintain sterility. It is crucial not to freeze the medication as it may affect its potency. Always check the expiration date on the packaging, and discard any expired or unused vials responsibly. Proper disposal methods should be followed, such as returning them to a pharmacy or healthcare facility for safe disposal. Keep the medication out of children's reach to prevent accidental exposure or ingestion.

Following are the quick tips for Paracetamol 300mg Injection:

• Administer the injection under medical supervision for accurate dosage and safe administration.
• Ensure the injection is given in a clean and sterile environment to prevent infection.
• Paracetamol injection is commonly used for rapid pain relief and fever reduction.
• It is often prescribed for conditions like postoperative pain, severe headache, or high body temperature.
• Do not inject if the solution appears cloudy or contains particles.
• Report any persistent or worsening symptoms to your healthcare provider promptly.
• Store the injection at room temperature, away from direct sunlight and moisture.