Provate-G (0.1/1mg) 15g Ointment

Betamethasone, a potent synthetic corticosteroid, exerts its anti-inflammatory and immunosuppressive effects by binding to cytoplasmic glucocorticoid receptors. Once bound, the corticosteroid-receptor complex migrates to the nucleus, where it regulates gene expression by inducing the synthesis of lipocortin, which inhibits phospholipase A2 and reduces the formation of pro-inflammatory mediators such as prostaglandins and leukotrienes. Additionally, betamethasone suppresses the production of various inflammatory cytokines, including interleukins and tumor necrosis factor-alpha (TNF-α). Gentamicin, an aminoglycoside antibiotic, works by binding to the 30S ribosomal subunit of susceptible bacteria, leading to mistranslation of bacterial proteins and disruption of bacterial cell wall synthesis. This binding interferes with protein synthesis, causing errors in the reading of mRNA, which ultimately leads to bacterial cell death. The combination of betamethasone and gentamicin in the ointment provides both anti-inflammatory and antibacterial effects, making it effective in treating inflammatory skin conditions with secondary bacterial infections.

Betamethasone, Gentamycin

Corticosteroid, Aminoglycoside antibiotic.

Ointment

The following are the uses of Betamethasone, Gentamycin Ointment:

• Used for reducing inflammation and redness in various skin conditions like eczema, psoriasis, and dermatitis.
• Used for treating skin infections caused by bacteria, especially in wounds or burns.
• Used for managing skin irritation and itching associated with allergic reactions.
• Used for promoting healing in surgical wounds or cuts.
• Used for alleviating symptoms of insect bites and stings.
• Used for providing relief from itching and inflammation in hemorrhoids.
• Used for preventing and treating infections in minor skin injuries.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Applied to the affected area once or twice a day.
• It is important to avoid covering the treated area with bandages or dressings after application to allow the skin to breathe and prevent further skin irritation.
• Consult a healthcare professional for precise dosage and treatment duration as it would depend on the individual's condition and response to treatment.

In the case of an overdose of Betamethasone and Gentamicin Ointment, the severity of symptoms can vary. Ocular exposure may result in increased intraocular pressure, while prolonged use can lead to glaucoma. Skin exposure may cause skin atrophy, striae, and hypersensitivity reactions. If ingested, nausea, vomiting, and gastrointestinal discomfort can occur. Promptly seek medical advice for guidance on managing these potential adverse effects.

In the case of a missed dose of Betamethasone, it is recommended to apply the ointment as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra medication to make up for the missed dose. For Gentamycin Ointment, if you forget to apply it, apply it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Avoid applying extra ointment to compensate for the missed application.

To apply Betamethasone, Gentamycin Ointment, clean and dry the affected area, then gently apply a thin layer of the ointment, following the prescribed frequency, typically twice a day, or as directed by your healthcare provider.

Following are the conditions or situations when Betamethasone, Gentamycin Ointment should not be used:

• Should not be used on individuals with a known allergy to Betamethasone, Gentamicin, or any other similar antibiotics.
• Avoid using on open wounds, broken skin, or deep puncture wounds.
• Not suitable for individuals with a history of skin reactions or sensitivity to any of the ointment's components.
• Contraindicated for individuals with certain skin infections like viral infections (cold sores, chickenpox), fungal infections, or tuberculosis of the skin.
• Do not use on skin areas with acne, rosacea, or perioral dermatitis.
• Avoid using on skin areas with thin skin, such as the face, unless directed by a healthcare professional.
• Not recommended for long-term use, especially on large areas of the body, due to the risk of systemic absorption.
• Should not be used on children, especially on large areas of the body, without medical supervision.

The side effects of Betamethasone, Gentamycin Ointment may include:

• Skin irritation or itching at the application site
• Thinning of the skin
• Redness or discoloration of the skin
• Increased hair growth in the treated area
• Acne or pimples
• Burning or stinging sensation
• Allergic reactions, such as rash, swelling, or difficulty breathing
• Increased susceptibility to infections

Following are the precautions and warnings for Betamethasone, Gentamycin Ointment:

• Do not use if you are allergic to any of its ingredients, including betamethasone or gentamicin.
• This medication is for external use only; avoid contact with eyes and mucous membranes.
• Wash your hands before and after applying the ointment to avoid accidental transfer to sensitive areas.
• Do not apply to open wounds, infections, or severely burned skin without medical advice.
• Prolonged use may cause skin thinning, so use it for the shortest duration necessary.
• If you are pregnant or breastfeeding, consult your doctor before using this medication.
• Keep this medication out of reach of children and pets.

Following are the drug interactions for Betamethasone, Gentamycin Ointment:

• Concomitant use with other topical corticosteroids or antibiotics may increase the risk of skin thinning, striae, and skin infections.
• Gentamicin, when absorbed systemically, can interact with other ototoxic drugs, such as loop diuretics, increasing the risk of hearing loss.
• Betamethasone may enhance the systemic absorption of other drugs applied topically, such as other corticosteroids or antifungal agents.
• Use with other immunosuppressants may increase the risk of infection and mask the signs of infection.
• Caution is advised when using with oral anticoagulants, as it may alter the drug's effect on blood clotting.
• The ointment may reduce the effectiveness of live vaccines, so vaccination schedules should be adjusted accordingly.
• Topical use with other drugs that cause photosensitivity reactions may increase the risk of sunburn and skin reactions.

Following are the food interactions with Betamethasone, Gentamycin Ointment:

• Betamethasone may cause increased appetite and weight gain, so it is advisable to maintain a balanced diet and monitor calorie intake.
• Avoid excessive salt intake as Betamethasone can lead to fluid retention and increased blood pressure.
• Limit the consumption of foods high in potassium and calcium, as Gentamicin can affect their levels.
• Avoid grapefruit and grapefruit juice, as they may interfere with the metabolism of Gentamicin, leading to increased drug levels.
• Alcohol may increase the risk of gastrointestinal side effects and should be consumed in moderation or avoided.
• Maintain a consistent vitamin D and calcium intake to support bone health, as long-term use of corticosteroids like Betamethasone can affect bone density.
• Ensure a healthy diet rich in nutrients to support overall health and manage potential side effects.
• Stay hydrated by drinking adequate water, especially if experiencing increased thirst or dry mouth.

Betamethasone and Gentamycin Ointment should be stored in a cool and dry place, preferably at room temperature (68°F to 77°F). Keep the tube tightly closed when not in use to maintain its integrity and prevent contamination. It is crucial to store the ointment away from light, heat, and moisture, as these factors can degrade the medication. Do not refrigerate or freeze the ointment. Always check the expiration date before application, and dispose of any leftover or expired medication responsibly. Proper disposal methods include returning it to a pharmacy or a designated medicine take-back program to minimize environmental impact. Keep the ointment out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Betamethasone, Gentamycin Ointment:

• Wash your hands before and after applying the ointment to maintain hygiene.
• Clean and dry the affected area before applying the ointment.
• Apply a thin layer as directed, gently massaging it into the skin.
• Avoid applying the ointment on broken or infected skin.
• Do not cover the treated area with bandages unless advised by your doctor.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Inform your doctor if you experience any skin irritation or allergic reactions.

When taking Betamethasone 0.5mg and Gentamycin 1mg, it is crucial to undergo certain lab tests to ensure your body's safety and to monitor any potential side effects. These tests are essential to optimize effectiveness and safety, while also allowing your healthcare provider to tailor the tests to your specific requirements. Here are the crucial lab tests that you should undertake: