Qusel XR (200mg) 10 Tablets

Quetiapine 200mg tablets primarily act as an atypical antipsychotic agent by interacting with multiple neurotransmitter receptors in the brain. Its mechanism of action involves antagonizing dopamine receptors, specifically D2 receptors, in the mesolimbic and mesocortical pathways, which helps regulate emotional and cognitive processes. Quetiapine also exhibits antagonist activity at serotonin receptors, particularly 5-HT2A receptors, leading to decreased serotonergic neurotransmission. This dual action is thought to contribute to its therapeutic effects in managing psychotic disorders. Additionally, quetiapine's ability to modulate the histamine H1 and alpha-adrenergic receptors may contribute to its sedative properties and potential for improving sleep in patients. The combined effect of these receptor interactions results in the medication's overall efficacy in treating conditions such as schizophrenia and bipolar disorder.

Antipsychotic

Tablet

The following are the uses of Quetiapine 200mg Tablet:

• Used for managing symptoms of schizophrenia, helping patients control hallucinations, delusions, and disordered thinking.
• Used to treat episodes of mania or depression in bipolar disorder, stabilizing mood swings.
• Used as a sleep aid for individuals with severe insomnia, particularly in those with mental health disorders.
• Used to reduce agitation and anxiety in various mental health conditions, promoting a sense of calm.
• Used in certain cases to manage severe depression when other treatments have not been effective.
• Used to control aggressive or impulsive behaviors, aiding in emotional regulation.
• Used to support overall mental health and functioning in individuals with serious mental illnesses.

In the case of an overdose of Quetiapine 200mg Tablets, it is important to recognize the signs and act promptly. Symptoms may include severe drowsiness, rapid heartbeat, and difficulty breathing. If an overdose is suspected, seek medical assistance immediately. Quick action can prevent serious health complications, and a healthcare professional should be consulted for proper guidance and treatment options. Timely intervention is key to managing the potential risks associated with Quetiapine overdose.

In the case of a missed dose of Quetiapine 200mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your dosing schedule and ensure you are taking the medication as prescribed.

To take Quetiapine 200mg Tablet, swallow the tablet whole with a glass of water, preferably at bedtime or as directed by your healthcare professional, ensuring you follow the prescribed dosage and schedule provided by your doctor.

Following are the conditions or situations when Quetiapine 200mg Tablet should not be taken:

• Should not be taken by individuals with a known allergy to Quetiapine or any of its ingredients.
• Not suitable for children and adolescents below 18 years of age.
• Contraindicated in patients with a history of stroke or transient ischemic attack (TIA).
• Should not be used in patients with liver or kidney impairment.
• Avoid using if you have a history of heart problems, such as heart disease or irregular heart rhythm.
• Not recommended for individuals with certain blood disorders, such as low white blood cell count or bone marrow depression.
• Contraindicated in patients with uncontrolled seizures or epilepsy.
• Should not be taken by pregnant women or those planning to become pregnant, as it may cause harm to the unborn baby.
• Avoid using if you have a personal or family history of glaucoma (increased eye pressure).
• Not suitable for individuals with certain mental health conditions, such as dementia or Parkinson's disease.

The side effects of Quetiapine 200mg Tablet may include:

• Dizziness and lightheadedness
• Dry mouth
• Increased appetite and weight gain
• Fatigue and drowsiness
• Blurred vision
• Constipation
• Increased heart rate
• Muscle stiffness or restlessness

Following are the precautions and warnings for Quetiapine 200mg Tablet:

• Do not abruptly stop taking this medication, as it may lead to withdrawal symptoms. Gradually reduce the dosage under medical supervision.
• This medication may cause drowsiness and dizziness; avoid driving or operating heavy machinery until you know how it affects you.
• Elderly patients may be more sensitive to the side effects, particularly dizziness, lightheadedness, and orthostatic hypotension.
• Use with caution in patients with a history of seizures, as it may lower the seizure threshold.
• Quetiapine may cause weight gain and changes in cholesterol and blood sugar levels; regular monitoring is recommended.
• Patients with a history of heart disease, stroke, or mini-stroke should inform their doctor before taking this medication.
• This medication may cause low blood pressure, especially when standing up from a sitting or lying position.

Following are the drug interactions for Quetiapine 200mg Tablet:

• Quetiapine may enhance the effects of central nervous system depressants like benzodiazepines, opioids, or alcohol, leading to increased sedation and respiratory depression.
• It can increase the risk of arrhythmias when used with other medications that prolong the QT interval, such as certain antiarrhythmics or antipsychotics.
• Antihypertensive medications' effects may be reduced, as quetiapine can cause orthostatic hypotension.
• Anticonvulsant levels, such as carbamazepine or phenytoin, may be decreased by quetiapine, potentially reducing seizure control.
• Antipsychotic effects may be increased when combined with other antipsychotics, leading to higher risks of side effects.
• The metabolism of Quetiapine can be affected by strong CYP3A4 inhibitors, resulting in increased quetiapine concentrations.
• CYP3A4 inducers may decrease quetiapine levels, potentially reducing its efficacy.
• Concomitant use with other medications that lower the seizure threshold, such as bupropion or tramadol, may increase the risk of seizures.

Following are the food interactions for Quetiapine 200mg Tablet:

• Consumption of alcohol should be avoided as it can increase the sedative effects, leading to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice are to be avoided as they can increase Quetiapine levels in the blood by inhibiting the enzyme CYP3A4, potentially raising the likelihood of side effects.
• High-fat meals may slightly increase Quetiapine absorption, so it's advisable to maintain a consistent diet pattern.
• Avoid caffeine-rich foods and beverages as they may exacerbate anxiety and restlessness, especially during the initial phase of treatment.
• Foods with tyramine, like aged cheese and cured meats, should be limited as they can interact with Quetiapine, causing a spike in blood pressure.
• Avoid herbal remedies like St. John's Wort, as it can decrease Quetiapine levels, reducing its effectiveness.
• Always ensure a balanced diet, as Quetiapine may increase appetite and lead to weight gain.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Quetiapine 200mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, or moisture. The original container should be used to keep the tablets, ensuring the lid is tightly sealed to maintain their integrity. It is crucial not to store them in the bathroom or kitchen due to temperature fluctuations. Always check the expiration date, and for proper disposal, do not flush or pour the medication down the drain; instead, consult a pharmacist or healthcare professional for safe disposal methods. Keep the tablets out of children's reach to prevent accidental consumption. Proper storage and disposal practices are essential for maintaining the effectiveness of the medication and ensuring safety.

Following are the quick tips for Quetiapine 200mg Tablet:

• Consult a doctor for proper dosage and duration based on your condition.
• Swallow the tablet whole with water; do not crush, chew, or break it.
• Take it at the same time each day to maintain consistent blood levels.
• It can be taken with or without food, but be consistent with your choice.
• Avoid alcohol while taking this medication as it may intensify side effects.
• Inform your doctor about all medications you use to prevent interactions.
• Store in a cool, dry place away from direct sunlight and moisture.