Renitec (5mg) 20 Tablets

Enalapril, the active ingredient in Enalapril 5mg Tablets, acts as an angiotensin-converting enzyme (ACE) inhibitor. Its primary mechanism of action involves blocking the conversion of angiotensin I to angiotensin II by inhibiting the ACE enzyme. Angiotensin II is a potent vasoconstrictor, so by inhibiting its production, enalapril reduces systemic vascular resistance. This leads to decreased arterial blood pressure, as well as reduced afterload on the heart, making it easier for the heart to pump blood. Additionally, the reduced angiotensin II levels result in decreased aldosterone secretion, leading to increased excretion of sodium and water by the kidneys, which further contributes to the reduction in blood pressure.

Enalapril 5mg

Angiotensin-converting enzyme (ACE) inhibitor

Tablet

The following are the uses of Enalapril 5mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to improve survival rates after a heart attack
• Used for managing heart failure
• Used to prevent kidney damage in those with diabetes
• Used to relax blood vessels, easing blood flow
• Used to reduce strain on the heart
• Used for patients with left ventricular dysfunction
• Used to slow the progression of kidney disease

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• High blood pressure- Enalapril Maleate 5mg is typically prescribed for the treatment of high blood pressure, also known as hypertension. The recommended dosage for adults range from 5-20 mg per day, to be taken as a single dose or divided into two smaller doses.
• Congestive Heart Failure (CHF)- Enalapril Maleate 5mg is commonly used to treat congestive heart failure. For CHF, the recommended starting dose is typically lower, around 2.5-5 mg per day. The dosage may be increased gradually every 2-4 weeks until the target dose is reached, or up to a maximum of 40 mg per day.
• Angina- Enalapril Maleate 5mg is also used to treat symptoms of angina, which is chest pain or pressure due to insufficient blood flow to the heart. For the treatment of angina, the recommended starting dose is typically lower, about 1.25-5 mg per day. The dosage may be adjusted every 2-4 weeks until the target dose of 20 mg per day is reached, or as advised by the doctor.

In the case of an overdose of Enalapril 5mg Tablets, several symptoms may occur, including a significant drop in blood pressure, leading to lightheadedness or fainting. Other potential signs include kidney failure, high levels of potassium in the blood, and reduced kidney function. It is crucial to seek medical advice immediately if you suspect an overdose, as prompt treatment can mitigate these effects and prevent further complications. Timely intervention is key to managing the situation effectively.

In the case of a missed dose of Enalapril 5mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. It is advisable to set a reminder or use a pill organizer to help you remember to take your medication on time and reduce the chances of missing a dose. Consult your healthcare provider if you frequently miss doses, as they can provide guidance on how to manage your medication regimen effectively.

To take Enalapril 5mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Enalapril 5mg Tablet should not be used:

• Avoid if you have a known allergy to Enalapril or other ACE inhibitors.
• Do not use if you have a history of angioedema (swelling under the skin) with previous ACE inhibitor use.
• Contraindicated in pregnant women, especially during the second and third trimesters.
• Should not be used in individuals with a history of severe renal impairment or renal artery stenosis.
• Not recommended for patients with a history of hyperkalemia (high potassium levels).
• Avoid if you have a history of aortic valve stenosis or hypertrophic cardiomyopathy.
• Do not use in patients undergoing dialysis or those with recent kidney transplant.
• Contraindicated in patients with a history of hereditary angioedema.

The side effects of Enalapril 5mg Tablet may include:

• Dizziness
• Fatigue or weakness
• Cough
• Headache
• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Loss of taste

Following are the precautions and warnings for Enalapril 5mg Tablet:

• Do not take this medication if you are allergic to Enalapril or any other ACE inhibitors.
• Patients with a history of kidney or liver disease should exercise caution and consult their doctor, as dosage adjustments might be necessary.
• Enalapril may cause dizziness or lightheadedness, so activities requiring alertness should be avoided until you know how the medication affects you.
• If you have a history of angioedema, use with caution as Enalapril may cause facial swelling, tongue, or throat.
• Diabetic patients should monitor blood sugar levels regularly as Enalapril may cause fluctuations.
• Avoid potassium supplements and potassium-rich foods without medical advice, as Enalapril can affect potassium levels.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Enalapril may have potential risks for the fetus and infant.

Following are the drug interactions for Enalapril 5mg Tablet:

• When combined with diuretics (water pills) like furosemide or thiazide diuretics, it may increase the risk of hypotension (low blood pressure).
• Enalapril can potentiate the effects of other antihypertensive medications, leading to excessive blood pressure reduction.
• The use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Enalapril.
• Lithium levels can be increased by Enalapril, potentially causing lithium toxicity.
• Potassium-sparing diuretics or potassium supplements may lead to elevated potassium levels when used with Enalapril.
• Enalapril may increase the risk of hyperkalemia when taken with angiotensin II receptor blockers (ARBs).
• Drugs that inhibit the renin-angiotensin system, such as direct renin inhibitors, may increase the risk of renal impairment when used concurrently with Enalapril.

Following are the food interactions to be aware of when taking Enalapril 5mg Tablet:

• Avoid consuming high-sodium foods like processed snacks, canned soups, and salty condiments, as Enalapril may lead to increased sodium retention.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation as Enalapril may elevate potassium levels.
• Limit your alcohol intake, as it can lower your blood pressure further and increase the risk of dizziness.
• Avoid potassium supplements unless prescribed by your doctor, as Enalapril may affect potassium levels.
• Grapefruit and grapefruit juice should be consumed sparingly, as they can interfere with the metabolism of Enalapril, leading to increased drug levels in the body.
• Maintain a balanced diet, as Enalapril may cause fluctuations in blood sugar and cholesterol levels.
• Stay hydrated, but be cautious with excessive fluid intake, especially if you have heart or kidney issues.
• Follow your healthcare provider's dietary advice, especially if you have specific dietary restrictions or health conditions.

Enalapril 5mg Tablets should be stored in a cool and dry place, preferably at room temperature (around 25°C/77°F). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. It is crucial to maintain a consistent storage environment, avoiding exposure to extreme heat or cold, as it can degrade the medication's quality. Always check the expiration date, and do not use the tablets if they are past their expiry. When disposing of unused or expired tablets, do not flush them or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Enalapril 5mg Tablet:

• Start with a low dose and gradually increase as directed by your doctor to minimize side effects.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Ensure you stay well-hydrated while taking this medication.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• Inform your doctor if you have a history of kidney or liver problems.
• Regular blood pressure monitoring is essential while on this medication.
• Avoid salty foods and maintain a balanced diet to support overall health.
• Store the tablets in a cool, dry place, away from direct sunlight.

Before starting Enalapril Maleate medication, your doctor will advise you to undertake essential safety tests to ensure the efficacy and safety of the medication. These tests vary regarding frequency and specifics depending on the individual's age, clinical condition, and other medications taken. One of the critical tests is blood pressure monitoring. This is to monitor the effectiveness of the blood pressure medication and ensure your blood pressure is within a safe range. Routine kidney function tests are recommended as Enalapril can cause kidney abnormalities, specifically relating to sodium and potassium retention. To mitigate this, it is imperative to monitor kidney function through regular tests that include serum creatinine and blood urea nitrogen (BUN). Periodic monitoring of potassium levels is necessary as Enalapril can cause low potassium levels known as (hypokalemia). This is especially essential for individuals who are susceptible to potassium depletion. Sodium levels may also need periodic monitoring as Enalapril can cause sodium retention, thereby increasing the risk of high sodium levels, concentrated in cases of severe hypertension or preexisting kidney disease. Since Enalapril is metabolized by the liver and puts it under stress, routine liver function tests are essential to ensure the medication does not cause any harm to the liver. These may include tests such as bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), and liver enzymes. Lastly, a low red blood cell count may be monitored as Enalapril may cause this and lead to anemia. Remember, your doctor will prescribe the right tests and their frequency given your particular situation.