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Rifa 4 Plus 100 Tablets
- Manufacturer Schazoo Pharmaceutical Laboratories (Pvt.) Ltd.
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Generic Name
Ethambutol, Isoniazid, Rifampicin, Pyrazinamide
Healthwire Pharmacy Ratings & Reviews (1500+)
Product Information
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Description
Rifampin is thought to inhibit bacterial DNA-dependent RNA polymerase, which appears to occur as a result of drug binding in the polymerase subunit deep within the DNA/RNA channel, facilitating direct blocking of the elongating RNA. The known mode of action of isoniazid (INH) is to inhibit bacterial cell wall synthesis following activation by the bacterial catalase–peroxidase enzyme KatG in Mycobacterium tuberculosis. Ethambutol exerts its bacteriostatic activity by virtue of inhibition of arabinosyl transferase which is an enzyme necessary for the synthesis of bacterial cell wall
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Ingredients
Ethambutol, Isoniazid, Rifampicin, Pyrazinamide
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Drug Class
Antibiotic
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Dosage Form
Tablet
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Uses
Ethambutol, Isoniazid, Rifampicin, Pyrazinamide combination is utilized for the following therapeutic indications:
- Treatment of active pulmonary tuberculosis
- Effective against multi-drug resistant tuberculosis
- Synergistic effect in combination therapy
- Reduces risk of relapse after initial treatment
- Prophylaxis in high-risk populations with latent tuberculosis infection
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Dosage
To be used as per doctor's prescription
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In case of Overdose
Acute poisoning due to isoniazid, ethambutol and rifampicin overdose is often associated with generalized tonic-clonic seizures, altered sensorium, renal, hepatic dysfunctions, and severe metabolic acidosis. Adverse effects such as pruritus, joint pain, gastrointestinal upset, abdominal pain, malaise, headache, dizziness, mental confusion, disorientation, and possible hallucinations can also occur. Seek immediate help in case of overdose
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Missed Dose
Try not to miss a dose. If you miss a dose, take it as soon as you can. Then continue your normal schedule. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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How To Use
Use and dosage must be determined by the doctor
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When Not to Use
Do not use in case of:
- allergy to drug itself
- active liver disease
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Side Effects
Common side effects incllude:
- bloody or cloudy urine
- blurred vision
- depression
- convulsions
- sore throat
- mood or mental changes
- unusual bleeding or bruising
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Precautions & Warnings
Cautions include:
- Use should be withdrawn immediately if severe acute hypersensitivity occurs
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Drug Interactions
This medication may interact with these drugs:
- oral anticoagulants
- oral contraceptives
- glucocorticoids
- digitoxin
- methadone
- barbiturates
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Storage/Disposal
Store in a cool, dry place away from sunlight. Keep away from children
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Control Drug
No
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Quick Tips, if any
Do not self-medicate
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