Risek Insta (40mg) 10 Sachets

Omeprazole (PPI) works by blocking the proton pumps in the stomach lining. These proton pumps are responsible for secreting hydrogen ions (protons) into the stomach, which combine with chloride ions to form hydrochloric acid. By inhibiting these proton pumps, omeprazole significantly reduces the production of stomach acid. Sodium bicarbonate is a common antacid and alkalinizing agent used to neutralize stomach acid and adjust the pH of various body fluids. Sodium bicarbonate reacts with hydrochloric acid (HCl) in the stomach to form sodium chloride, water and carbon dioxide. This reaction neutralizes excess stomach acid, reducing acidity. When absorbed into the bloodstream, sodium bicarbonate can help to increase blood pH, providing temporary relief from metabolic acidosis (a condition where the body produces too much acid).

Proton Pump Inhibitor, Antacid

This sachet is used to treat:

• Gastroesophageal Reflux Disease (GERD)
• Stomach Ulcers
• Increased Gastric Acid

Omeprazole dosage recommendations are:

• Acid-related dyspepsia - 10 mg or 20 mg daily for 2-4 weeks.
• Helicobacter pylori eradication - As triple therapy - 20 mg bid for 7 or 10 days with clarithromycin and amoxicillin or metronidazole (or tinidazole). Alternatively - 40 mg once daily for 1 week with amoxicillin and metronidazole (or tinidazole). As dual therapy - 40 mg once daily for 14 days with clarithromycin. For children >4 years - 15-30 kg - 10 mg bid for 1 week, >30 kg - 20 mg bid for 1 week.
• Gastric ulcer - 20 mg once daily for 4-8 weeks, may increase to 40 mg once daily if needed. Maintenance - 20 mg once daily, may increase to 40 mg once daily if needed.
• Duodenal ulcer - 20 mg once daily for 2-4 weeks, may increase to 40 mg once daily if needed. Maintenance - 10-20 mg once daily, may increase to 40 mg once daily if needed.
• NSAID-associated ulceration - 20 mg once daily for 4 weeks, may continue for another 4 weeks if needed.
• Gastro-oesophageal reflux disease - 10-20 mg once daily, adjust according to response. For children ≥1 year - 10-20 kg - 10 mg once daily for 2-4 weeks, may increase to 20 mg once daily if needed, ≥2 years >20 kg - 20 mg once daily for 2-4 weeks, may increase to 40 mg once daily if needed.
• Reflux oesophagitis - 20 mg once daily for 4-8 weeks. Severe cases - 40 mg once daily for 8 weeks. Maintenance - 10 mg once daily, may increase to 20-40 mg once daily if needed. For children ≥1 year - 10-20 kg - 10 mg once daily for 4-8 weeks, may increase to 20 mg once daily if needed, ≥2 years >20 kg - 20 mg once daily for 4-8 weeks, may increase to 40 mg once daily if needed.
• Zollinger-Ellison syndrome - Initially - 60 mg daily, adjust according to response. Usual dose - 20-120 mg daily, with doses >80 mg given in 2 divided doses.
• Prophylaxis of NSAID-induced ulcers - 20 mg once daily in at-risk patients.

Seek immediate medical attention. Symptoms may include confusion, drowsiness, blurred vision, and vomiting. Follow medical advice.

Take the missed dose as soon as you remember. If it is close to the next dose, skip the missed dose. Do not take extra to make up for the missed dose.

Dissolve the contents of one sachet in water. Stir well and take it orally as directed by your healthcare provider.

The combination of omeprazole and sodium bicarbonate should not be used in the following situations:

• Hypersensitivity to omeprazole or any other ingredient in the formulation
• Severe hypocalcemia or metabolic alkalosis

The side effects of Omeprazole and Sodium Bicarbonate combination are as follows:

• Gastrointestinal discomfort
• Headache
• Dizziness
• Allergic reactions

When using this medication, it is important to be aware of the following precautions and warnings:

• Symptomatic response to therapy does not rule out the presence of gastric malignancy; further evaluation may be necessary if symptoms persist.
• Exercise caution during pregnancy and lactation, consulting a healthcare professional to ensure safety.
• For Risek and Insta Omeprazole, long-term therapy may be associated with atrophic gastritis. Use with caution in patients on a sodium-restricted diet.
• Sodium bicarbonate should be avoided in patients with Bartter's syndrome, hypokalemia, respiratory alkalosis, or acid-base imbalances. Long-term use may lead to milk-alkali syndrome, particularly when combined with calcium or milk.

Drug interactions with omeprazole and sodium bicarbonate include:

• Antifungal agents (e.g., ketoconazole) (omeprazole may reduce absorption)
• Antiretrovirals (e.g., atazanavir) (omeprazole may decrease effectiveness)
• Clopidogrel (omeprazole may reduce the activation of clopidogrel)
• Methotrexate (high doses may have increased levels due to decreased renal excretion)
• Sodium bicarbonate (may alter gastric pH and affect drug absorption- consider timing of administration)
• Antacids (e.g., magnesium hydroxide) (may interfere with the absorption of omeprazole- administer separately)

Store at room temperature in a tightly closed container. Dispose of unused or expired medication by returning it to a pharmacy for safe disposal.