Safgo-Met (2/500mg) 30 Tablets

Metformin, at a dosage of 500mg, primarily acts by inhibiting glucose production in the liver. It does this by suppressing gluconeogenesis and glycogenolysis, two processes responsible for glucose formation. This action reduces the liver's glucose output, subsequently lowering blood sugar levels. On the other hand, Glimepiride 2mg stimulates insulin release from the pancreas. It belongs to the sulfonylurea class of drugs, which block ATP-sensitive potassium channels in pancreatic beta cells, leading to their depolarization and subsequent insulin secretion. This increased insulin level facilitates the uptake of glucose by cells, thereby reducing blood glucose concentrations.

Oral anti-diabetic combination

Tablet

The following are the uses of Metformin 500mg, Glimepiride 2mg Tablet:

• Used for controlling blood sugar levels in type 2 diabetes.
• Used to improve insulin sensitivity and reduce insulin resistance.
• Used to support weight loss and manage obesity.
• Used to lower the risk of cardiovascular complications associated with diabetes.
• Used to prevent long-term diabetes complications.
• Used to enhance glycemic control in combination with lifestyle changes.
• Used to treat prediabetes and prevent its progression to type 2 diabetes.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take 2mg tablet of Glimepiride with breakfast or the first meal of the day.
• Take Glimepiride alone, at least 10 minutes before or after a meal.
• Adjust the Glimepiride dose based on blood glucose levels and glycemic control. But, do not take more than 16mg daily.
• Start with a usual dose of Metformin Hydrochloride is 500mg once or twice daily with meals.
• Maximum dose of Metformin Hydrochloride is 2500mg daily. Divide the total daily dose into smaller doses to be taken with each meal.

In the case of an overdose of Metformin 500mg and Glimepiride 2mg tablets, individuals may experience symptoms such as severe nausea, vomiting, rapid breathing, dizziness, and extreme weakness. It is important to seek medical assistance promptly as an overdose can lead to lactic acidosis, a serious condition characterized by a dangerous buildup of lactic acid in the body. Emergency treatment may include gastric lavage, fluid replacement, and close monitoring of vital signs to prevent potential complications.

In the case of a missed dose of Metformin 500mg, it is generally recommended to take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Glimepiride 2mg, if a dose is missed, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and do not double the dose to catch up. It's important to maintain a consistent medication schedule, and if you frequently miss doses, consult your healthcare provider for advice.

To take the Metformin 500mg and Glimepiride 2mg tablet, swallow the tablet whole with a full glass of water, preferably during or after a meal, as directed by your healthcare provider, typically once or twice a day, following the prescribed dosage instructions.

Following are the conditions/situations when Metformin 500mg and Glimepiride 2mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Metformin or Glimepiride or any of the tablet's components.
• Contraindicated in patients with kidney disease or severe kidney problems.
• Not suitable for individuals with severe liver disease or liver failure.
• Should not be used if you have a history of diabetic ketoacidosis.
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for individuals with respiratory diseases or severe breathing problems.
• Should not be given to patients with a history of heart disease or heart failure.
• Avoid if you have a scheduled surgery or any medical/dental procedure.
• Not suitable for individuals with a history of heavy alcohol consumption.

The side effects of Metformin 500mg, Glimepiride 2mg Tablet may include:

• Nausea and vomiting
• Diarrhea or constipation
• Stomach pain or upset
• Metallic taste in the mouth
• Dizziness or lightheadedness
• Skin rash or itching
• Increased sweating
• Low blood sugar (hypoglycemia)

Following are the precautions and warnings for Metformin 500mg, Glimepiride 2mg Tablet:

• Patients with a known allergy to Metformin or Glimepiride should not take this medication.
• Kidney function should be regularly monitored, and caution is advised in patients with a history of kidney problems as dosage adjustments may be necessary.
• Liver function tests are recommended during treatment, especially in patients with pre-existing liver conditions.
• Patients with a history of heart disease or respiratory problems should be cautious and inform their healthcare provider.
• Alcohol consumption should be avoided or limited as it may increase the risk of side effects and affect blood sugar levels.
• Discontinue the medication and seek medical attention if any signs of lactic acidosis appear, such as unusual muscle pain, weakness, or stomach discomfort.
• This medication may cause hypoglycemia (low blood sugar); be aware of symptoms and carry a source of glucose to treat it promptly.
• Elderly patients may be more susceptible to the side effects of this medication and should be monitored closely.

Following are the drug interactions for Metformin 500mg, Glimepiride 2mg Tablet:

• Alcohol intake can increase the risk of lactic acidosis with metformin.
• Glimepiride may interact with sulfonamide antibiotics, affecting blood sugar levels.
• Caution with nonsteroidal anti-inflammatory drugs (NSAIDs), as they can reduce the effectiveness of glimepiride.
• Corticosteroids may increase blood glucose, requiring careful monitoring.
• Beta-blockers may mask hypoglycemic symptoms, necessitating regular blood sugar checks.
• Certain medications like rifampicin can decrease the efficacy of glimepiride.
• Metformin may interact with contrast agents, requiring temporary discontinuation before imaging procedures.
• Drugs affecting kidney function may influence metformin elimination.

Following are the food interactions for Metformin 500mg, Glimepiride 2mg Tablet:

• Alcohol consumption should be limited as it can interfere with blood sugar control and may increase the risk of hypoglycemia or lactic acidosis.
• Avoid excessive intake of grapefruit and grapefruit juice as it may affect the metabolism of Glimepiride, leading to increased drug levels and potential side effects.
• Patients should maintain a consistent carbohydrate intake to ensure stable blood sugar levels.
• Avoid high-fat meals as they can delay the absorption of Glimepiride, affecting its effectiveness.
• Avoid or limit the consumption of foods rich in vitamin B12, as Metformin may reduce its absorption, potentially leading to B12 deficiency over time.
• Do not consume large amounts of dairy products, as they may contain high levels of calcium, which can interact with Metformin.
• Inform your doctor if you have a significant change in diet or start a high-fiber meal plan, as it may require medication adjustments.
• Always follow the dietary recommendations provided by your healthcare professional for optimal blood sugar management.

Metformin 500mg, Glimepiride 2mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures or store it in humid areas like bathrooms. Always check the expiration date before use, and if the tablets have expired or are no longer needed, proper disposal is essential. Consult your pharmacist or local waste management guidelines for safe disposal methods, ensuring that the medication is not flushed or poured down the drain, as this can impact the environment. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Metformin 500mg, Glimepiride 2mg Tablet:

• Take the medication as directed by your doctor, typically with meals.
• Swallow the tablets whole without crushing or chewing.
• Maintain a consistent medication schedule for better control.
• Avoid alcohol as it may increase the risk of side effects.
• Inform your doctor about other medications to prevent interactions.
• Regularly monitor blood sugar levels as advised by your healthcare provider.
• Store the medication in a cool, dry place, away from sunlight.
• Contact your doctor if you experience persistent nausea or unusual tiredness.

While on medication such as Glimepiride and Metformin Hydrochloride, it is important to regularly monitor your blood sugar levels to ensure they remain in a healthy range. Fasting Blood Sugar (FBS) tests, which measure glucose levels after an 8-hour fast, help determine how effective insulin response and medication are. Postprandial Blood Sugar (PPBS) tests, which are conducted after a meal, assess blood sugar rise specifically after meals and aid in diagnosing and gauging the severity of diabetes. The HbA1C test provides a 2-3 month average of blood sugar levels and is vital for long-term control. Kidney function tests, including serum creatinine and estimated glomerular filtration rate (eGFR), are necessary to ensure the kidneys are not harmed by Metformin excretion. To manage diabetes responsibly, healthy cholesterol levels must be maintained, so a lipid profile to assess total cholesterol, LDL, HDL, and triglycerides may be advised. Even blood oxygen levels are important to monitor as diabetes elevates the risk of cardiovascular problems, and potassium levels should be tracked as well. Overall, when taking these medications, it is essential to collaborate with a healthcare provider who will oversee necessary testing, prescribe appropriate medication adjustments, and offer valuable advice on diet, exercise, and lifestyle changes to best manage diabetes and associated conditions.