Scicon-MR (60mg) 30 Tablets

Gliclazide, a second-generation sulfonylurea, primarily acts by stimulating insulin release from pancreatic beta cells. It selectively binds to sulfonylurea receptors on the beta cell membrane, leading to the inhibition of ATP-sensitive potassium channels. This inhibition results in membrane depolarization, opening of voltage-gated calcium channels, and subsequent calcium influx, which triggers insulin secretion. Gliclazide enhances insulin synthesis and promotes the maturation of insulin-containing secretory granules. It also improves insulin sensitivity by increasing the number of insulin receptors and enhancing insulin-mediated glucose uptake in peripheral tissues, particularly skeletal muscle and adipose tissue. This mechanism of action helps lower blood glucose levels in individuals with type 2 diabetes.

Gliclazide 60mg

Sulfonylurea (antidiabetic)

Tablet

The following are the uses of Gliclazide 60mg Tablet:

• Used for managing type 2 diabetes by controlling blood sugar levels.
• Used to improve insulin sensitivity and reduce insulin resistance.
• Used to stimulate the pancreas to release more insulin.
• Used for reducing the risk of diabetic complications.
• Used for managing diabetes when diet and exercise alone are not sufficient.
• Used to enhance glucose uptake by muscle cells, leading to better blood sugar control.
• Used for long-term blood sugar management, helping to prevent diabetes-related health issues.
• Used as part of a comprehensive diabetes treatment plan, often alongside lifestyle changes.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Take one tablet per day as your doctor suggests.
• Your doctor will determine the treatment length based on your symptom severity.

In the case of an overdose of Gliclazide 60mg Tablets, symptoms may include severe hypoglycemia, leading to dizziness, confusion, and in extreme cases, loss of consciousness. Prompt action is required; consume a fast-acting source of glucose like sugar cubes or honey, and seek medical advice immediately. If symptoms persist or worsen, call emergency services. Timely intervention is vital, as untreated hypoglycemia can result in severe complications, including seizures and permanent neurological damage.

In the case of a missed dose of Gliclazide 60mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. It is crucial not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Gliclazide 60mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning before breakfast, as directed by your healthcare provider, ensuring you follow the prescribed dosage and schedule.

Following are the conditions when Gliclazide 60mg Tablet should not be taken:

• Avoid if you have a known allergy to Gliclazide or other sulfonylurea medications.
• Not suitable for individuals with type 1 diabetes.
• Should not be used if you are in a state of diabetic ketoacidosis.
• Contraindicated in individuals with severe liver or kidney disease.
• Not recommended for those with certain blood disorders, such as a low white blood cell count or severe anemia.
• Avoid if you have a history of porphyria.
• Do not take if you are breastfeeding, as it may harm the infant.
• Gliclazide is not recommended for children and adolescents under 18 years of age.
• Should not be used if you have a scheduled surgery or any medical test, as it may interfere with blood sugar control.

The side effects of Gliclazide 60mg Tablet may include:

• Hypoglycemia (low blood sugar)
• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea or constipation
• Skin rashes or itching
• Allergic reactions (skin rash, itching, difficulty breathing)
• Weight gain
• Visual disturbances (blurred or altered vision)

Here are the precautions and warnings for Gliclazide 60mg Tablet:

• Gliclazide should not be used in patients with a known allergy or hypersensitivity to sulfonylureas or any of the tablet's components.
• Regular monitoring of blood glucose levels is essential, and patients should be aware of the symptoms of hypoglycemia and hyperglycemia.
• Patients with kidney or liver impairment may require dosage adjustments, and close monitoring is necessary.
• Alcohol consumption should be avoided or limited as it can affect blood sugar control and increase the risk of hypoglycemia.
• Gliclazide may cause dizziness or blurred vision, so patients should be cautious when driving or operating machinery.
• Not recommended for use in children or adolescents, and elderly patients may require lower initial doses.
• Pregnant and breastfeeding women should consult their doctor as the use of gliclazide during pregnancy and breastfeeding requires careful consideration.
• Patients should be educated about the importance of maintaining a consistent diet and exercise routine while taking this medication.

Following are the drug interactions for Gliclazide 60mg Tablet:

• Gliclazide may increase the effects of sulfonamides, phenylbutazone, and warfarin, leading to potential side effects.
• The blood-glucose-lowering effect can be enhanced when used with other antidiabetic medications, insulin, or other sulfonylureas.
• Caution is advised with beta-blockers, ACE inhibitors, or diuretics, as these drugs may mask the symptoms of hypoglycemia.
• Gliclazide may interact with gemfibrozil, increasing the risk of hypoglycemia.
• Avoid alcohol consumption as it may enhance the hypoglycemic effect.
• Drugs affecting liver function, like rifampicin, may reduce the efficacy of gliclazide.
• Some drugs affecting kidney function, such as diuretics, may prolong the effect of gliclazide.

Following are the food interactions for Gliclazide 60mg Tablet:

• Alcohol consumption should be avoided or limited as it can interfere with blood sugar control and increase the risk of hypoglycemia.
• Grapefruit and grapefruit juice may alter the blood levels of the medication, potentially affecting its effectiveness. It's advisable to avoid consuming them together.
• High-fiber foods like whole grains, legumes, and vegetables can affect the absorption of Gliclazide. Consume a consistent amount of fiber to maintain stable blood sugar levels.
• Fatty meals can delay the absorption of Gliclazide, potentially affecting its efficacy. Take the medication as directed, regardless of meal composition.
• Consuming large amounts of garlic may increase the risk of bleeding when taking Gliclazide, as garlic has natural blood-thinning properties.
• Licorice can potentially interfere with blood sugar regulation and should be consumed in moderation or avoided while on Gliclazide.
• Vitamin C supplements or foods rich in vitamin C may affect blood sugar levels, so monitor your intake and consult your healthcare provider for guidance.
• Inform your healthcare provider about your dietary habits, especially if you have a significant intake of herbs, spices, or dietary supplements, as some may interact with Gliclazide.

Gliclazide 60mg Tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial to ensure that the medication is stored away from children and pets to prevent accidental ingestion. Do not use the tablets if the packaging is damaged or shows signs of tampering. Dispose of any unused or expired medication responsibly; do not flush or pour them into drainage systems. Contact your pharmacist or healthcare provider for guidance on proper disposal methods to ensure environmental safety.

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Following are the quick tips for Gliclazide 60mg Tablet:

• Consult your doctor before taking this medication and provide your complete medical history.
• Take the tablet as directed by your doctor, typically once or twice daily.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Maintain a consistent dosing schedule, preferably with meals or as advised by your doctor.
• Regularly monitor your blood sugar levels and inform your doctor of any changes.
• Do not stop taking the medication without consulting your doctor, even if you feel better.
• Inform your doctor about all medications you are taking to avoid potential drug interactions.