Selgin (5mg) 50 Tablets

Selegiline 5mg Tablet primarily exerts its therapeutic effects through selective and irreversible inhibition of monoamine oxidase-B (MAO-B). MAO-B is an enzyme responsible for breaking down certain neurotransmitters, particularly dopamine, in the brain. By inhibiting MAO-B, Selegiline increases the levels of dopamine in the brain, which is believed to contribute to its antidepressant and neuroprotective properties. This mechanism is particularly relevant in conditions where dopamine deficiency is implicated, such as Parkinson's disease. Selegiline's selective inhibition of MAO-B allows for a more targeted approach, minimizing the risk of side effects associated with non-selective MAO inhibitors.

MAO-B inhibitor.

Tablet

The following are the uses of Selegiline 5mg Tablet:

• Used for treating depression, especially in elderly patients, as it enhances the effects of certain neurotransmitters in the brain.
• Used for managing symptoms of Parkinson's disease by increasing dopamine levels, which improves motor function.
• Used for supporting smoking cessation efforts by reducing nicotine withdrawal symptoms and decreasing the urge to smoke.
• Used for enhancing cognitive function in certain conditions like cognitive impairment and Alzheimer's disease.
• Used for improving mood and energy levels, particularly in those with seasonal affective disorder (SAD).
• Used for alleviating fatigue and promoting a sense of well-being in individuals with chronic conditions.
• Used for managing certain movement disorders, such as restless leg syndrome, due to its dopamine-enhancing properties.
• Used for its potential neuroprotective effects, which may slow down the progression of neurodegenerative diseases.

In the case of an overdose of Selegiline 5mg Tablets, it is important to recognize the potential symptoms, which may include severe headache, dizziness, confusion, and agitation. Prompt action is necessary, including contacting a healthcare professional or poison control center for guidance. Treatment may involve managing symptoms and providing supportive care to ensure the patient's well-being. Quick response and appropriate medical advice are crucial in such situations.

In the case of a missed dose of Selegiline 5mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely adjust your medication schedule and ensure the best treatment outcome. It is crucial to maintain a consistent medication routine for optimal effectiveness.

To take Selegiline 5mg Tablet, place the tablet on your tongue and allow it to dissolve without chewing or crushing, preferably on an empty stomach, at the same time each day as directed by your doctor.

Following are the conditions or circumstances when Selegiline 5mg Tablet should not be taken:

• Must be avoided in individuals with a known allergy or hypersensitivity to Selegiline or any of its inactive ingredients.
• Not suitable for patients who are concurrently taking certain medications, such as meperidine, tramadol, propoxyphene, methadone, dextromethorphan, cyclobenzaprine, and St. John's wort.
• Contraindicated in individuals with pheochromocytoma, a rare tumor of the adrenal gland.
• Should not be used in patients with severe high blood pressure or uncontrolled hypertension.
• Not recommended for individuals with severe liver disease or liver impairment.
• Must be avoided in patients with a history of orthostatic hypotension (a sudden drop in blood pressure upon standing).
• Not suitable for individuals with a history of severe psychiatric disorders, such as schizophrenia or bipolar disorder.
• Contraindicated in patients who have recently taken a monoamine oxidase inhibitor (MAOI) or are taking other medications that can interact with Selegiline.
• Should not be used during pregnancy or while breastfeeding, as the risks are not fully established.

The side effects of Selegiline 5mg Tablet may include:

• Nausea and vomiting
• Dizziness and lightheadedness
• Insomnia and sleep disturbances
• Dry mouth
• Constipation or diarrhea
• Skin rashes or itching
• Confusion and hallucinations
• Increased heart rate or blood pressure fluctuations

Following are the precautions and warnings for Selegiline 5mg Tablet:

• Selegiline should not be used in patients with a known hypersensitivity or allergy to the drug or any of its components.
• Patients with a history of psychiatric disorders, such as schizophrenia or bipolar disorder, should use this medication with caution as it may exacerbate symptoms.
• It is important to monitor blood pressure regularly during treatment, as Selegiline can cause orthostatic hypotension.
• Patients should avoid consuming large amounts of foods rich in tyramine, such as aged cheeses, cured meats, and certain beverages, as this may lead to a potentially dangerous increase in blood pressure.
• Selegiline can interact with other medications, including antidepressants and opioids, so patients should inform their doctor about all medications they are taking.
• Caution is advised in patients with liver or kidney disease, as the dosage may need to be adjusted.
• This medication is not recommended for use in children and adolescents, as its safety and efficacy have not been established in this population.
• Selegiline may cause drowsiness and dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.

Following are the drug interactions for Selegiline 5mg Tablet:

• Concurrent use with other antidepressants like SSRIs, SNRIs, or TCAs can lead to serotonin syndrome, a potentially serious condition.
• Selegiline should not be combined with other monoamine oxidase inhibitors (MAOIs) as it may cause severe hypertension or other adverse effects.
• Drugs metabolized by CYP450 enzymes, especially CYP2C19, may have increased levels when taken with Selegiline, requiring dosage adjustments.
• The effectiveness of levodopa may be reduced when used with Selegiline, and there is an increased risk of adverse effects like dyskinesia.
• Tricyclic antidepressants and antipsychotics may interact with Selegiline, leading to increased side effects and potential toxicity.
• Opioid pain medications can interact with Selegiline, potentially causing respiratory depression and sedation.
• Caution is advised with sympathomimetic drugs, as Selegiline may potentiate their effects, leading to increased blood pressure and heart rate.

Following are the food interactions to consider with Selegiline 5mg Tablet:

• Avoid consuming foods high in tyramine, such as aged cheeses, cured meats, fermented foods, and certain types of beer. These can interact with Selegiline and cause a dangerous spike in blood pressure.
• Avoid consuming foods with a high sugar content, as Selegiline can affect blood sugar levels.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Selegiline, potentially increasing its levels in the body.
• Alcohol may increase the risk of side effects and should be consumed in moderation, if at all, while taking Selegiline.
• Caffeine-rich foods and beverages should be limited as they can interact with Selegiline and affect blood pressure.
• Avoid consuming large amounts of high-protein foods, as they may reduce the absorption of Selegiline.
• Always maintain a balanced diet and follow any dietary advice provided by your healthcare professional.

The proper storage and disposal of Selegiline 5mg Tablets are crucial for safety and environmental considerations. Store the tablets in a dry and cool environment, away from sunlight and moisture, preferably in their original container with the lid tightly sealed. Maintain a consistent room temperature to preserve the medication's integrity. It is essential to adhere to the recommended storage conditions and avoid exposing the tablets to extreme temperatures. Always check the expiration date, and if the medication is expired or no longer needed, proper disposal is essential. Do not flush the tablets or throw them into the trash; instead, consult your pharmacist or healthcare provider for specific instructions on how to safely dispose of pharmaceutical waste, ensuring that the medication is kept away from children and pets at all times.

Following are the quick tips for Selegiline 5mg Tablet:

• Consult your doctor for the right dosage and duration of this medication.
• Take the tablet as directed, preferably at the same time each day.
• Do not crush or chew the tablet; swallow it whole with a glass of water.
• Avoid consuming foods and beverages high in tyramine while on this medication.
• Inform your doctor about all medications and supplements you are taking.
• Do not stop taking the medication without consulting your doctor to prevent withdrawal symptoms.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Keep the medication out of reach of children and pets.