Septran (80/400mg) 400 Tablets

Trimethoprim and Sulfamethoxazole, the active components of the Trimethoprim-Sulfamethoxazole Tablet, exert their antibacterial effects through distinct mechanisms. Trimethoprim inhibits the enzyme dihydrofolate reductase, which is crucial for the production of tetrahydrofolate, a vital component in the synthesis of DNA, RNA, and proteins in bacteria. By blocking this enzyme, Trimethoprim disrupts the bacterial cell's ability to replicate and maintain essential cellular functions. On the other hand, Sulfamethoxazole acts by competitively inhibiting the enzyme dihydropteroate synthase, which is involved in the synthesis of folic acid. This inhibition prevents the formation of dihydrofolic acid, another essential compound in the bacterial synthesis of nucleic acids and proteins. Together, the combined action of Trimethoprim and Sulfamethoxazole disrupts critical metabolic pathways in bacteria, leading to their growth inhibition and eventual death.

Sulfonamide/Folic Acid Antagonist

Tablet

The following are the uses of Trimethoprim, Sulfamethoxazole Tablet:

• Used for treating a wide range of bacterial infections, including urinary tract infections, respiratory tract infections, and ear infections.
• Used for its effectiveness against bacteria that are resistant to other antibiotics.
• Used for preventing and treating traveler's diarrhea.
• Used for managing Pneumocystis jirovecii pneumonia in individuals with compromised immune systems.
• Used for suppressing certain types of bacterial infections in patients with HIV/AIDS.
• Used for its ability to treat skin and soft tissue infections caused by susceptible bacteria.
• Used as an alternative for patients allergic to penicillin-based antibiotics.

To be taken as per doctor's prescription. It is usually given up to 10-14 days

In the case of an overdose of Trimethoprim, Sulfamethoxazole Tablets, individuals may experience symptoms such as nausea, vomiting, and diarrhea. In more severe cases, it can lead to kidney or liver problems. It is important to seek medical advice immediately if an overdose is suspected. Prompt action can help prevent potential health risks and ensure appropriate treatment, including supportive care and managing any adverse effects that may arise from the excess medication.

In the case of a missed dose of Trimethoprim, Sulfamethoxazole Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. It is recommended to maintain a consistent dosing routine to ensure the medication's effectiveness. If you frequently miss doses, consult your healthcare provider for advice on how to improve your medication adherence.

To take Trimethoprim, Sulfamethoxazole Tablet, swallow the tablet whole with a full glass of water, following the prescribed dosage as directed by your healthcare professional, typically taken twice daily, with or without food, for the duration of the treatment period.

Following are the conditions/situations when Trimethoprim, Sulfamethoxazole Tablet should not be used:

• Should not be used in individuals with a known allergy to Trimethoprim, Sulfamethoxazole, or other sulfa drugs.
• Contraindicated in patients with severe kidney or liver disease.
• Not recommended for individuals with a history of blood disorders, such as low platelet count or anemia.
• Should not be used in patients with a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD).
• Contraindicated in newborns up to 2 months of age due to the risk of jaundice and other severe side effects.
• Not suitable for individuals with a history of severe allergic reactions or asthma.
• Should be avoided in patients with severe folate deficiency.
• Must not be used in individuals with a history of porphyria, a group of blood disorders.

The side effects of Trimethoprim, Sulfamethoxazole Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Skin rashes or itching
• Dizziness or lightheadedness
• Fatigue and weakness
• Joint pain or muscle aches

Following are the precautions and warnings for Trimethoprim, Sulfamethoxazole Tablet:

• Avoid using this medication if you have a known allergy to trimethoprim, sulfamethoxazole, or any sulfa drugs. Severe allergic reactions may occur.
• This medication can affect blood cell counts, so regular blood tests are required to monitor for any abnormalities.
• Patients with liver or kidney disease should use this medication with caution as it may worsen their condition and dosage adjustments may be necessary.
• Inform your doctor if you have any folate deficiency or anemia before starting this medication.
• Elderly patients may be more susceptible to side effects, particularly skin reactions.
• Avoid excessive exposure to sunlight or UV rays as this medication can increase sensitivity, leading to severe sunburns.
• Trimethoprim, Sulfamethoxazole Tablet should be used with caution in pregnant and breastfeeding women, and only if the potential benefits outweigh the risks.

Following are the drug interactions for Trimethoprim, Sulfamethoxazole Tablet:

• Concomitant use with other antibiotics like doxycycline or rifampin may reduce the effectiveness of Trimethoprim/Sulfamethoxazole, as these drugs can compete for the same metabolic pathways.
• Warfarin and other oral anticoagulants may have their effects enhanced, leading to potential bleeding risks.
• Trimethoprim/Sulfamethoxazole can increase digoxin levels, requiring close monitoring of digoxin concentrations.
• Phenytoin, a commonly used anticonvulsant, may have decreased efficacy when used with this drug combination.
• The combination may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Methotrexate levels can be elevated, increasing the risk of methotrexate toxicity.
• Theophylline metabolism may be affected, potentially leading to increased theophylline concentrations and associated side effects.

Following are the food interactions to consider with Trimethoprim, Sulfamethoxazole Tablet:

• Avoid excessive sun exposure as the medication can make your skin more sensitive to sunlight, increasing the risk of sunburn. Limit time in the sun and wear protective clothing and sunscreen.
• Alcohol consumption should be minimized or avoided as it may increase the risk of liver-related side effects and could potentially reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of the drug, leading to increased levels in the blood and potential side effects.
• Maintain adequate fluid intake to prevent dehydration, especially if experiencing diarrhea or vomiting.
• Avoid high-sodium foods as this medication may cause sodium retention, and excessive sodium intake can increase blood pressure.
• Ensure a balanced diet as this medication may affect the absorption of certain nutrients like folate and vitamin B12.
• No specific food restrictions are required, but maintaining a healthy diet is generally advised.
• Consult your healthcare provider for personalized advice on diet and any necessary dietary adjustments during treatment.

Storage and disposal of Trimethoprim, Sulfamethoxazole Tablets are crucial for safety and environmental considerations. Store the tablets in a dry place at room temperature, ideally between 68°F and 77°F (20°C and 25°C), ensuring they are kept away from excessive heat, moisture, or direct sunlight. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Regularly check the expiration date, and if the tablets are expired or no longer needed, do not flush them or throw them into the trash. Contact your pharmacist or healthcare provider for guidance on proper disposal methods to ensure they are discarded in an environmentally friendly manner. Keep the medication out of children's reach to prevent accidental consumption.

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Following are the quick tips for Trimethoprim, Sulfamethoxazole Tablet:

• Take the tablet as directed by your doctor; do not crush or chew it.
• Complete the full prescribed course, even if you feel better early.
• Stay hydrated by drinking plenty of fluids while on this medication.
• Avoid prolonged exposure to sunlight and use sunscreen when outdoors.
• Inform your doctor about any allergies or medical conditions before starting the medication.
• Store the tablets at room temperature, away from moisture and light.
• Regularly monitor your health and report any severe side effects to your healthcare provider.