Sitaglu Met XR (50/500mg) 14 Tablets

Sitagliptin, a DPP-4 inhibitor, enhances the activities of GLP-1 and GIP, which leads to improved glycemic control in patients with type 2 diabetes. It achieves this by reducing fasting and post-prandial blood glucose levels. On the other hand, Metformin, a guanidine derivative, possesses antimicrobial properties. It reduces glucose production by the liver, increases glucose uptake by skeletal muscle, and enhances glucose uptake and utilization by anaerobic pathways in tissues such as the kidney. Additionally, it diminishes hunger and induces weight loss in some individuals. The combination of Sitagliptin 50mg and Metformin 500mg is typically prescribed to adults with type 2 diabetes when diet and exercise alone are not sufficient to manage blood sugar levels. It's worth noting that this description is a simplified overview, and the actual mechanisms of action for these drugs are more intricate and are still being researched.

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DPP4- Inhibitors

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Tablet

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Unveiling its multifaceted uses and transformative applications as follows:

• Treatment of type 2 diabetes mellitus
• Enhances the actions of incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)
• Delays the absorption of glucose in the blood stream
• Ensures gradual release of glucose and stimulates the pancreas to produce insulin
• Metformin acts by reducing the excessive secretion of glucose from the liver
• Downregulates glucose absorption in the gastrointestinal tract
• Increases the uptake of glucose by skeletal muscle
• Reduced chances of diabetic complications like neuropathy, retinopathy, and nephropathy

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For treating type 2 diabetes, the recommended dose of Sitagliptin is 50mg to be taken once a day.
• The recommended dose of Metformin ranges from 500mg to 2000mg depending on the severity of the patient's insulin resistance and their response to the medication.
• It is crucial to adhere to the prescription provided to you by your doctor.
• Please consult your doctor for any specific dosage instructions pertaining to your individualized health needs and medical history.

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An overdose of sitagliptin and metformin may result in low blood sugar, nausea, vomiting, dizziness, and headaches. It is vital to seek immediate medical attention in order to prevent any potential health complications. In order to treat overdose symptoms, doctors primarily focus on supporting the patient's vital signs, managing extreme symptoms, and reversing the effects of the overdose over time. This may include administering medications such as glucose or glucagon to stabilize blood sugar levels. If necessary, they may also provide treatment for nausea and vomiting. It is crucial that the patient is closely monitored by medical staff, who will pay careful attention to vital signs, glucose levels, and overall physiological state in order to ensure a full recovery from the overdose. They may also provide additional advice and guidance for managing and preventing future overdose incidents.

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It is important to consult with your doctor if you missed a dose of your medication. Your doctor will advise you on how to proceed based on your specific medication and health condition. In the case of medications like sitagliptin and metformin, if you missed a dose, it is recommended to take it as soon as possible. If it is close to your next scheduled dose, you can continue with your regular schedule and skip the missed dose to avoid taking a double dose. It is essential to avoid stopping or changing your medication regimen without discussing it with your doctor, as this can lead to complications. To ensure you make the right decision, always consult with your medical professional for specific guidance on managing missed doses. They will provide you with important safety information and advice tailored to your circumstances, helping you make the best possible decision.

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When taking Sitagliptin 50mg and Metformin 500mg, here are some important directions to follow:

• Take the medication exactly as prescribed by your doctor, usually with meals to reduce the risk of gastrointestinal side effects.

• Swallow the tablets whole with a glass of water; do not crush or chew them.

• If you miss a dose, take it as soon as you remember, unless it is close to your next dose. Do not double up doses to make up for the missed one.

• Regularly monitor your blood sugar levels as directed by your healthcare provider.

• Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of lactic acidosis, a rare but serious side effect.

• Continue following a balanced diet and exercise regimen alongside medication for optimal blood sugar control.

• Inform your healthcare provider of any new or worsening symptoms, especially those related to lactic acidosis, such as weakness, fatigue, or unusual muscle pain.

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Discerning instances where this medication may not be appropriate:

• Hypersensitivity
• Kidney problems
• Ongoing ketoacidosis
• Surgical anesthesia
• Certain drugs

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Unraveling the side effects lurking behind this medications are as follows:

• Increased risk of hypoglycemia (low blood sugar)
• Weight loss
• Fatigue
• Muscle pain

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The warnings and precautions for Metformin and Sitagliptin are:

• Patient with congestive heart failure (CHF)
• Those exposed to stress (e.g., infection, fever, trauma, surgery)
• Not intended for the treatment of diabetic ketoacidosis or type 1 diabetes mellitus
• Renal impairment (GFR 30-45 mL/min)
• Pregnancy

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The drug interactions with metformin and sitagliptin include:

• Other Antidiabetics – Can have additive hypoglycemic effects.
• CYP3A4 Inhibitors (e.g., ketoconazole) – Can increase sitagliptin levels.

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The food interactions that should be considered while using Metformin + Sitagliptin are:

• No significant interactions with food.

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Sitagliptin and Metformin are oral medications used to regulate blood sugar levels in patients with Type 2 Diabetes. When taking these medications, it is important to adhere to your physician's instructions carefully, which typically involves taking a combination of Sitagliptin 50mg and Metformin 500mg. To ensure the effectiveness of both medications, they should be stored properly.

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