SYNALAR GEL 30G

Fluocinolone Gel, a potent topical corticosteroid, exerts its therapeutic effects by binding to intracellular glucocorticoid receptors. Once bound, the drug-receptor complex migrates to the nucleus, where it regulates gene expression and modulates the synthesis of various inflammatory mediators. Specifically, fluocinolone inhibits the release of pro-inflammatory cytokines, such as interleukins and tumor necrosis factor-alpha (TNF-α), and suppresses the activity of immune cells, including T-cells and macrophages. This multi-faceted approach reduces inflammation, alleviates itching, and promotes the healing of affected skin areas. The selective binding affinity of fluocinolone for glucocorticoid receptors underpins its potent anti-inflammatory properties while minimizing systemic side effects.

Fluocinolone

Corticosteroid.

Gel

The following are the uses of Fluocinolone Gel:

• Used for reducing inflammation and relieving itching in various skin conditions like eczema, psoriasis, and dermatitis.
• Used for treating skin rashes and allergic reactions.
• Used for managing skin conditions that respond to steroid treatment.
• Used for relieving itching and discomfort in insect bites and mild skin injuries.
• Used for improving skin texture and reducing redness in certain skin disorders.
• Used for providing relief in cases of seborrheic dermatitis and scalp issues.
• Used for controlling inflammation in post-surgical skin recovery.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take note of the precise dosage instructions provided by your doctor and adhere to them meticulously
• If you have any concerns regarding the dosage, you must consult with your doctor before consuming the medication, assuring that you are not at any health risk

In the case of an overdose of Fluocinolone Gel, it is important to act promptly. Rinse the affected area with warm water and gently pat it dry. Avoid using excessive amounts of the gel and ensure proper application as directed by a healthcare professional. If ingested, contact a healthcare provider or poison control center for guidance on further steps to mitigate any potential adverse effects. Timely intervention can help manage any discomfort or complications effectively.

In the case of a missed dose of Fluocinolone Gel, it is important to apply the gel as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra gel to make up for the missed dose. If you frequently miss doses, it is advisable to set reminders or use a medication tracker to help you stay on track. Consult your healthcare provider if you have any concerns or if you miss multiple doses, as they can provide guidance tailored to your specific situation.

To use Fluocinolone Gel, gently apply a thin layer to the affected skin areas twice a day or as directed by your doctor, and rub it in thoroughly, being careful to avoid sensitive areas such as the eyes and mouth.

Here are the conditions or situations when Fluocinolone Gel should not be used:

• Allergy Should not be used if you are allergic to Fluocinolone Acetonide or any other ingredients in the gel.
• Skin Infections Not suitable for individuals with untreated bacterial, viral, or fungal skin infections.
• Skin Conditions Avoid using on skin with conditions like rosacea, acne, perioral dermatitis, or open wounds.
• Vaccination Sites Do not apply to skin areas where vaccinations have been given recently.

The side effects of Fluocinolone Gel may include:

• Thinning of the skin
• Burning or stinging sensation
• Irritation or redness at the application site
• Acne or skin rashes
• Increased hair growth in the treated area
• Skin discoloration or hypopigmentation
• Allergic reactions (such as itching, swelling, or difficulty breathing)
• Increased susceptibility to skin infections

Following are the precautions and warnings:

• Fluocinolone Gel is for external use only and should not be applied near the eyes, mouth, or open wounds.
• Do not use it if you are allergic to any of its ingredients, including fluocinolone acetonide or other corticosteroids.
• Avoid using this gel on infected skin areas; treat the infection first before applying the gel.
• Prolonged use of Fluocinolone Gel may cause thinning of the skin, stretch marks, or skin color changes; consult a doctor if these occur.
• Do not use it on large areas of the body or for extended periods without medical supervision.
• Avoid using occlusive dressings or bandages over the treated skin area as this may increase the absorption of the medication.
• This medication should be used with caution in children and elderly patients as they may be more sensitive to its effects.
• If irritation, redness, or any signs of allergic reaction occur, discontinue use and seek medical advice immediately.

Following are the drug interactions for Fluocinolone Gel:

• Concomitant use with other topical steroids or potent immunosuppressants can increase the risk of skin atrophy, striae, and telangiectasia.
• The gel may reduce the effectiveness of live vaccines and increase the risk of infection; avoid using live vaccines at the treatment site.
• Applying Fluocinolone Gel with other topical medications (e.g., retinoids, benzoyl peroxide) may increase skin irritation and dryness.
• Topical use with calcium channel blockers, especially oral or IV formulations, can lead to increased systemic absorption of the gel.
• The gel's effects may be reduced when used with topical astringents or exfoliants.
• Caution is advised when using the gel with other medications that affect the skin barrier, as this may increase drug absorption.
• Systemic absorption of the gel can be increased by occlusive dressings or application to large body areas, potentially interacting with other drugs.

Following are the food interactions to be aware of when using Fluocinolone Gel:

• Alcohol-based products should be avoided as they can cause skin dryness and irritation, especially on sensitive or broken skin.
• Grapefruit and grapefruit juice consumption should be limited as they may increase the absorption of certain steroids like Fluocinolone, potentially leading to increased side effects.
• High-fat meals may slow down the overall absorption of topical medications, although the effect is likely minimal for Fluocinolone Gel.
• Spicy foods can potentially aggravate skin conditions, especially if the skin is already irritated or sensitive.
• Chocolate and cocoa-rich products might influence skin conditions like acne, rosacea, or eczema, which could affect the overall effectiveness of Fluocinolone Gel.
• Sugary foods and beverages can lead to inflammation and skin irritation, potentially reducing the gel's efficacy.
• A balanced diet rich in vitamins, minerals, and antioxidants can support skin health and potentially enhance the gel's effectiveness.
• Staying well-hydrated is essential for overall skin health, ensuring the skin is better prepared to respond to the gel's treatment.

Fluocinolone Gel should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to expose the gel to extreme temperatures, so avoid storing it in hot areas like near stoves or inside bathrooms. Always be mindful of the expiration date, and dispose of any unused or expired gel responsibly. Proper disposal means not flushing it down the toilet or pouring it into drainage systems; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the gel out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Fluocinolone Gel:

• Wash your hands before and after applying the gel to maintain hygiene and prevent contamination.
• Clean and dry the affected area before applying the gel for better absorption.
• Use only a thin layer of the gel, gently rubbing it into the skin until it disappears.
• Avoid applying the gel to your face unless specifically directed by your doctor.
• Do not cover the treated area with bandages or tight clothing to allow proper ventilation.
• Wash your hands thoroughly after application, especially before handling contact lenses or touching your eyes.
• Regularly monitor your skin for any signs of improvement or adverse reactions while using the gel.

Fluocinolone (Acetonide) is a medication that comes with several laboratory tests that are essential to ensure the medication's effectiveness and monitor any potential side effects. These tests provide your doctors with information that will help them decide if any changes are needed for your treatment plan, such as adjusting the dosage or introducing additional interventions. The tests you may need to take while on this medication include: