Tapento IR (75mg) 10 Tablets

Tapentadol acts as an agonist at the mu-opioid receptors in the central nervous system. These receptors are part of the body’s natural pain control system. When tapentadol binds to these receptors, it mimics the action of endorphins, which are natural pain-relieving chemicals in the body. This binding reduces the perception of pain by blocking pain signals from reaching the brain. Tapentadol also inhibits the reuptake of norepinephrine. By preventing the reuptake of norepinephrine, tapentadol increases its levels in the synaptic cleft (the space between nerve cells), enhancing the descending pain inhibitory pathways. This helps to further reduce the sensation of pain.

Tapentadol dosage recommendations:

• Adult Dosage

The usual starting dose is 50 mg every 4 to 6 hours. Your doctor may prescribe a different, more appropriate dose or interval of dosing, if necessary. Total daily doses greater than 700 mg tapentadol on the first day of treatment and daily doses greater than 600 mg tapentadol on the following days are not recommended.

• Elderly Dosage

In elderly patients (above 65 years), usually no dose adjustment is necessary. However, excretion of tapentadol may be delayed, and your doctor may recommend a different dosage regimen if this applies to you.

• Child Dosage

Tapento IR is not suitable for children and adolescents below the age of 18 years.

For Tapentadol, after taking very high doses, you may experience severe symptoms such as pin-point pupils, vomiting, a drop in blood pressure, a rapid heartbeat, collapse, altered consciousness or coma, and potentially life-threatening respiratory issues like dangerously slow or shallow breathing, or complete cessation of breathing. If any of these symptoms occur, it is crucial to seek immediate medical attention by contacting a doctor right away.

If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed dose. Do not take double doses.

Tapentadol is for oral use. Swallow the tablets with sufficient liquid. You may take the tablets on an empty stomach or with meals.

Tapentadol should not be taken in the following situations:

• Allergy to tapentadol or any other ingredients of this medicine
• Asthma or dangerously slow or shallow breathing (respiratory depression, hypercapnia)
• Paralysis of the gut
• Acute poisoning with alcohol, sleeping pills, pain relievers, or other psychotropic medicines

headache. heartburn. stomach pain. dry mouth. excessive tiredness. anxiety.

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Tapentadol can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take this medicine in larger amounts, or for longer than prescribed. Do not crush, break, or open an extended-release tablet. Swallow it whole to avoid exposure to a potentially fatal dose.

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Drug interactions with tapentadol include:

• CNS depressants (e.g., alcohol, benzodiazepines) (may enhance CNS depression)
• MAO inhibitors (e.g., phenelzine) (may increase the risk of serotonin syndrome)
• SSRIs and SNRIs (e.g., fluoxetine, venlafaxine) (may increase the risk of serotonin syndrome)
• CYP2D6 inhibitors (e.g., quinidine) (may increase tapentadol levels)
• CYP3A4 inhibitors (e.g., ketoconazole) (may increase tapentadol levels)
• Antihypertensives (e.g., lisinopril) (may have additive hypotensive effects)

Store at room temperature, away from heat and moisture. Dispose of unused or expired medication via a take-back program or follow local pharmaceutical disposal guidelines.