Tarisin (0.025%) 15ml Nasal Spray

Flunisolide, a synthetic corticosteroid, exerts its therapeutic effects primarily through its anti-inflammatory and immunosuppressive properties. It binds to glucocorticoid receptors in various cell types, particularly immune cells, leading to a modulation of gene expression. This binding triggers a cascade of intracellular events, resulting in the suppression of multiple pro-inflammatory mediators, such as cytokines, leukotrienes, and prostaglandins. By inhibiting the production and release of these inflammatory substances, Flunisolide reduces inflammation in the airways, thereby alleviating symptoms associated with allergic and inflammatory respiratory conditions. The drug's selective binding to glucocorticoid receptors ensures its potent anti-inflammatory action while minimizing systemic side effects.

Flunisolide

Corticosteroid nasal spray

Spray

The following are the uses of Flunisolide Spary:

• Used for reducing inflammation in the nose and preventing sneezing, runny nose, and itching caused by allergies.
• Used for treating symptoms of seasonal allergic rhinitis (hay fever).
• Used to prevent nasal symptoms like congestion, sneezing, and itching in patients with allergic reactions to substances like pollen, dust mites, or pet dander.
• Used for providing relief from nasal discomfort and improving overall nasal function.
• Used for managing symptoms of chronic rhinitis, making breathing easier.
• Used as a long-term treatment option to decrease the body's response to allergens and reduce the need for other medications.
• Used for its anti-inflammatory properties to alleviate nasal inflammation and related discomfort.
• Used for patients who require continuous therapy during pollen seasons or those exposed to allergens year-round.

To be used as per doctor's prescription

In the case of an overdose of Flunisolide Spray, individuals may experience an array of symptoms. These can include a rapid or irregular heartbeat, heightened blood pressure, and a noticeable increase in thirst. Additionally, patients might exhibit signs of hyperactivity, restlessness, and even difficulty sleeping. If such an overdose occurs, it is of utmost importance to promptly seek medical assistance to address these symptoms and ensure the individual's well-being.

In the case of a missed dose of Flunisolide Spray, it is generally recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, inform your healthcare professional and follow their advice on how to get back on track with your medication regimen. Always consult your doctor or pharmacist if you have any concerns or questions about missed doses.

To use Flunisolide Spray, gently shake the container, prime the pump if it's your first use, tilt your head forward, insert the tip into one nostril, depress the pump while breathing gently through your nose, and repeat for the other nostril, following the prescribed dosage and instructions provided by your healthcare professional.

Following are the conditions/situations when Flunisolide Spray should not be used:

• Do not use if you have an active untreated infection in your nose or sinuses.
• Not suitable for individuals with a known allergy to Flunisolide or any of the spray's ingredients.
• Should not be used in individuals with recent nasal surgery or trauma until fully healed.
• Avoid using if you have a nasal ulcer, nasal sores, or recent nasal surgery.
• Not recommended for those with an untreated nasal or sinus condition, such as an abscess or infection.
• Do not use if you have a perforated nasal septum.
• Contraindicated in individuals with an active or recent history of tuberculosis.
• Should not be used in patients with untreated fungal, bacterial, or viral infections in the respiratory tract.
• Not suitable for children below a certain age (as specified by a healthcare professional).

The side effects of Flunisolide Spray may include:

• Nasal irritation or dryness
• Nose bleeds
• Headache
• Sore throat
• Hoarseness or voice changes
• Nausea
• Unpleasant taste or smell
• Allergic reactions (skin rash, itching, swelling)

Following are the precautions and warnings for Flunisolide Spray:

• This medication is for nasal use only; do not swallow or inject it.
• Do not use Flunisolide Spray if you are allergic to any of its ingredients.
• Before using this medication, inform your doctor about any medical conditions, especially nasal infections, injuries, or recent surgery.
• Avoid spraying the medication into your eyes or mouth. If contact occurs, rinse with plenty of water.
• Do not use the spray more frequently or at higher doses than prescribed, as it may lead to adverse effects.
• Children should use Flunisolide Spray under adult supervision to ensure proper administration.
• If you do not experience improvement in symptoms or if they worsen, consult your healthcare provider promptly.
• Inform your doctor about all medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Flunisolide Spray:

• Concurrent use with other corticosteroids may increase the risk of systemic side effects, including adrenal suppression.
• Flunisolide can interact with certain antifungal medications like ketoconazole, potentially leading to increased exposure of the corticosteroid.
• It may decrease the efficacy of live vaccines. Avoid live vaccines during and immediately after treatment.
• Interactions with immunosuppressants could potentially increase the risk of infection.
• Use with caution alongside non-potassium sparing diuretics, as it may increase the risk of hypokalemia.
• Flunisolide can increase blood glucose levels; monitor closely when used with antidiabetic medications.
• The effect of anticoagulants may be enhanced, requiring close monitoring of coagulation parameters.

Following are the food interactions to consider with Flunisolide Spray:

• Avoid consuming grapefruit or grapefruit juice, as they can inhibit the enzyme CYP3A4, leading to increased Flunisolide levels in the blood and potentially causing adverse effects.
• Alcohol consumption should be limited as it may increase the risk of gastrointestinal bleeding, especially if you have a history of stomach ulcers or gastrointestinal bleeding.
• Dairy products like milk, cheese, and yogurt can reduce the absorption of Flunisolide, so it is recommended to use the spray before consuming these foods.
• Spicy foods and hot beverages may irritate the throat and worsen symptoms, especially if you have a sore throat or cough.
• Chocolate contains compounds that can inhibit the action of Flunisolide, so it's best to limit its consumption during treatment.
• Vitamin D supplements may interact with Flunisolide, so consult your healthcare provider if you're taking any.
• Certain fruits like bananas, oranges, and tomatoes may cause throat irritation in some individuals, so monitor your tolerance.
• Avoid excessive consumption of sugary foods, as they can promote the growth of oral thrush, a fungal infection in the mouth.

Flunisolide Spray storage and disposal should be done with care to ensure safety and environmental responsibility. Store the spray in a cool and dry place, preferably at room temperature, away from direct sunlight and heat sources like radiators or stoves. Keep the spray bottle tightly sealed in its original packaging to maintain its integrity and prevent contamination. Always check the expiration date, and if the spray is past its prime or no longer needed, do not flush it or pour it down the drain. Consult your pharmacist or healthcare provider for guidance on proper disposal methods to avoid any potential harm to the environment. Keep the spray out of children's reach to prevent accidental exposure. Responsible storage and disposal practices are crucial for the safe handling of Flunisolide Spray.

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Following are the quick tips for Flunisolide Spray:

• Wash your hands before using the spray to maintain hygiene.
• Shake the spray bottle well before each use to ensure proper medication delivery.
• Prime the spray if it's your first use or if you haven't used it for a while, following the manufacturer's instructions.
• Aim the spray tip into your nostril and press down on the pump to release the medication.
• Breathe gently through your nose while spraying to ensure the medication reaches the nasal passages.
• Avoid blowing your nose immediately after using the spray for maximum effectiveness.
• Store the spray at room temperature, away from direct sunlight and heat.