Telmis-A (80/5mg) 14 Tablets

Telmisartan and Amlodipine work synergistically in the Telmisartan 80mg, Amlodipine 5mg Tablet to lower blood pressure. Telmisartan is an angiotensin II receptor blocker (ARB) that prevents the hormone angiotensin II from binding to its receptors, leading to vasodilation and reduced blood pressure. It selectively blocks the activation of the AT1 receptor, which is responsible for the vasoconstrictive and aldosterone-secreting effects of angiotensin II. Amlodipine, a calcium channel blocker, inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells, resulting in relaxation and dilation of blood vessels. This mechanism reduces peripheral vascular resistance and lowers blood pressure, complementing the action of telmisartan. Together, these two components effectively target different pathways involved in blood pressure regulation, providing a comprehensive approach to managing hypertension.

Angiotensin II receptor blocker, calcium channel blocker.

Tablet

The following are the uses of Telmisartan 80mg, Amlodipine 5mg Tablet:

• Used for managing high blood pressure, reducing the risk of heart attack and stroke.
• Used for treating hypertension and improving blood flow by relaxing blood vessels.
• Used to treat angina, reducing chest pain and improving exercise capacity.
• Used to lower blood pressure by blocking specific receptors in the body.
• Used for treating hypertension and heart failure, improving overall heart function.
• Used to manage hypertension, particularly in patients who have difficulty tolerating other medications.
• Used to prevent kidney damage and slow the progression of kidney disease in diabetic patients.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Telmisartan 80mg-
• Hypertension- Take 1 tablet once a day
• Coronary Artery Disease- Take 1 tablet once a day
• Stroke- Take 1 tablet once a day
• Heart Failure- Take 1 tablet once a day
• Amlodipine 5mg-
• Hypertension- Take 1 tablet once a day

In the case of an overdose of Telmisartan 80mg and Amlodipine 5mg tablets, immediate medical attention is necessary. Symptoms may include a rapid drop in blood pressure, dizziness, and lightheadedness. Prompt action should be taken, such as contacting a healthcare professional or poison control center for guidance on managing the overdose. It is important to provide them with information about the medication, the amount ingested, and any observed symptoms to ensure appropriate treatment and support.

In the case of a missed dose of Telmisartan 80mg, Amlodipine 5mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. Always consult your doctor or pharmacist for specific instructions related to your prescription.

To take the Telmisartan 80mg and Amlodipine 5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider, ensuring you do not crush or chew the tablet.

Following are the conditions/situations when Telmisartan 80mg, Amlodipine 5mg Tablet should not be taken:

• Should not be used in patients with a known allergy or sensitivity to Telmisartan, Amlodipine, or other related medications.
• Not recommended for individuals with severe liver or kidney impairment.
• Contraindicated in pregnant or breastfeeding women.
• Should be avoided in patients with a history of angioedema or swelling of the face, lips, tongue, or throat.
• Not suitable for individuals with severe low blood pressure or hypotension.
• Should not be used in patients with aortic stenosis or obstructive valvular heart disease.
• Contraindicated in patients with bile duct obstruction or cholestasis.
• Should be discontinued if there is evidence of liver problems or elevated liver enzymes.
• Not recommended for individuals with a history of intestinal or urinary obstruction.

The side effects of Telmisartan 80mg, Amlodipine 5mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Swelling in the ankles, feet, or legs (peripheral edema)
• Headache
• Nausea or stomach pain
• Increased heart rate (tachycardia)
• Skin rashes or itching
• Muscle cramps

Following are the precautions and warnings for Telmisartan 80mg, Amlodipine 5mg Tablet:

• Patients with known allergies to Telmisartan, Amlodipine or related compounds should not take this medication.
• It should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Elderly patients may be more sensitive to the effects of this medication, especially dizziness and lightheadedness.
• Patients with a history of heart disease, including aortic stenosis, should be closely monitored while taking this medication.
• This medication can cause dizziness; patients should avoid driving or operating heavy machinery until they know how it affects them.
• Avoid the consumption of alcohol as it may increase the risk of side effects and further lower blood pressure.
• Telmisartan can cause fetal harm; pregnant women and women planning to become pregnant should not take this medication.
• Consult your doctor if you have any history of medical conditions or are taking any other medications to ensure safe use.

Following are the drug interactions for Telmisartan 80mg and Amlodipine 5mg Tablet:

• Telmisartan may increase the blood levels of lithium, leading to lithium toxicity. Close monitoring of lithium levels is necessary.
• The use of nonsteroidal anti-inflammatory drugs (NSAIDs) with Telmisartan can reduce its blood pressure-lowering effect and may increase the risk of kidney problems.
• Amlodipine can enhance the blood pressure-lowering effect of other antihypertensive medications, leading to excessive hypotension.
• When combined with CYP3A4 inhibitors like ketoconazole or clarithromycin, Amlodipine's metabolism may be affected, resulting in increased drug levels and potential side effects.
• Amlodipine may increase the blood levels of cyclosporine, tacrolimus, and simvastatin, requiring dose adjustments.
• Grapefruit juice should be avoided as it can increase Amlodipine's blood levels, potentially leading to an increased risk of side effects.
• Caution is advised when using Telmisartan with diuretics, as it may cause excessive blood pressure drop and impaired kidney function.

Following are the food interactions for Telmisartan 80mg, Amlodipine 5mg Tablet:

• Avoid consuming excessive amounts of potassium-rich foods like bananas, oranges, and tomatoes, as Telmisartan can increase potassium levels in the body.
• Limit the consumption of foods high in sodium, as Amlodipine can interact with sodium levels.
• Grapefruit and grapefruit juice should be consumed with caution, as they may affect the metabolism of Amlodipine, leading to increased drug levels in the blood.
• Alcohol may cause excessive lowering of blood pressure and increased side effects, so moderation is advised.
• Avoid or limit high-fat meals, as they can decrease the absorption of Telmisartan.
• Caffeine intake should be monitored, as it may affect blood pressure and interact with the medication's effectiveness.
• Follow a balanced diet as directed by your healthcare provider to maintain a healthy blood pressure and overall well-being while on this medication.

Telmisartan 80mg, Amlodipine 5mg Tablets should be stored in a dry and cool environment, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in bathrooms or areas exposed to heat, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods, and always keep medications away from children to prevent accidental consumption.

Following are the quick tips for Telmisartan 80mg, Amlodipine 5mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet whole with a sufficient amount of water.
• Maintain a consistent time for taking the medication each day.
• Avoid crushing, chewing, or breaking the tablet for optimal absorption.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your blood pressure and consult your doctor for adjustments if needed.

Lab tests are not required as a part of taking Telmisartan and Amlodipine, however, patients must regularly monitor their blood pressure to ensure the medication is effective. While your doctor may request additional lab tests, they are not specifically required due to the consumption of these drugs. These tests may include a Complete Blood Count (CBC) and kidney function test (eGFR). Your doctor may also call for blood tests to monitor potassium levels and your lipid profile. These tests are not routinely performed and should be conducted at your doctor's advice on how often to take place. It is important to inform your doctor of any unusual symptoms you experience while taking these medications and to attend annual check-ups to assure your blood pressure is under control.