Tenofo-B (300mg) 30 Tablets

Tenofovir, the active ingredient in the 300mg tablet, primarily acts as a nucleotide reverse transcriptase inhibitor (NRTI). It is a prodrug that undergoes phosphorylation within the body to become the active form, tenofovir diphosphate. This active metabolite selectively inhibits viral reverse transcriptase, an enzyme crucial for the replication of certain viruses, particularly HIV and hepatitis B virus (HBV). By competing with the natural substrate deoxyadenosine 5'-triphosphate (dATP), tenofovir diphosphate effectively blocks the reverse transcription process, preventing the synthesis of viral DNA. This mechanism significantly reduces the ability of the virus to replicate and spread, thereby suppressing viral load and contributing to the management and treatment of HIV and HBV infections.

Nucleoside reverse transcriptase inhibitor.

Tablet

The following are the uses of Tenofovir 300mg Tablet:

• Used for treating chronic hepatitis B virus (HBV) infection in adults and children.
• Used for managing HIV infection, helping control the virus and improve immune function.
• Used as a preventive measure for HIV-negative individuals at high risk of infection.
• Used in combination with other antiretroviral drugs to suppress the HIV virus.
• Used to lower the risk of HIV transmission to uninfected partners.
• Used for long-term management of HIV, helping patients maintain a suppressed viral load.
• Used in tailored treatment plans to suit individual patient needs.

In the case of an overdose of Tenofovir 300mg Tablets, it is important to recognize the potential risks and take appropriate action. The effects of an overdose may include severe nausea, abdominal pain, and acute kidney injury. If an overdose is suspected, it is crucial to seek medical assistance promptly. Quick response can help mitigate potential health risks and ensure the patient receives the necessary treatment and support to manage any adverse effects effectively. Timely intervention is key to minimizing the impact of a Tenofovir overdose.

In the case of a missed dose of Tenofovir 300mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to adjust your dosing schedule or provide specific instructions to ensure the medication's effectiveness. It is essential to maintain a consistent dosing routine for optimal treatment results.

To take Tenofovir 300mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, once daily or as directed by your healthcare professional, ensuring you follow the prescribed dosage instructions provided.

Following are the conditions or situations when Tenofovir 300mg Tablet should not be used:

• Should not be taken by individuals with known hypersensitivity or allergy to Tenofovir or any of its excipients.
• Not recommended for patients with severe kidney impairment or end-stage renal disease.
• Contraindicated in patients who are also taking certain medications that may interact with Tenofovir, such as Ledipasvir/Sofosbuvir, Adefovir, or other similar drugs.
• Should not be used in patients with a history of liver disease or significant liver dysfunction.
• Not suitable for individuals with bone diseases or conditions like osteoporosis or low bone mineral density.

The side effects of Tenofovir 300mg Tablet may include:

• Nausea and vomiting
• Fatigue and weakness
• Headache
• Diarrhea
• Dizziness
• Stomach pain
• Skin rash
• Kidney problems (decreased kidney function, abnormal urine tests)

Following are the precautions and warnings for Tenofovir 300mg Tablet:

• Not recommended for individuals with known hypersensitivity or allergy to Tenofovir or any of its excipients.
• Regular monitoring of kidney function is essential, especially in patients with underlying kidney disease, as Tenofovir can cause nephrotoxicity.
• Patients with liver disease should exercise caution as Tenofovir is primarily eliminated by the liver.
• It may cause lactic acidosis, a serious condition, and should be discontinued if symptoms like nausea, stomach pain, and weakness occur.
• Patients should be advised to maintain adequate hydration to reduce the risk of kidney damage.
• This medication does not prevent the transmission of HIV or other sexually transmitted infections; proper precautions should still be taken.
• Patients should be informed about the potential for redistribution or accumulation of body fat, a condition known as lipodystrophy.

Following are the drug interactions for Tenofovir 300mg Tablet:

• Tenofovir may interact with other nephrotoxic drugs (e.g., NSAIDs, certain antibiotics), increasing the risk of kidney damage, especially when used for prolonged periods or at high doses.
• Concurrent use with other antiretroviral drugs (e.g., lamivudine, emtricitabine) may increase the risk of lactic acidosis and severe hepatomegaly with steatosis. Close monitoring is recommended.
• Tenofovir may interact with drugs that affect renal function (e.g., diuretics, angiotensin-converting enzyme [ACE] inhibitors), which could increase the risk of kidney-related side effects.
• Combining Tenofovir with atazanavir or lopinavir/ritonavir may increase Tenofovir levels in the blood, leading to a higher risk of toxicity. Dose adjustments may be necessary.
• Use of Tenofovir with drugs that increase the risk of osteoporosis (e.g., corticosteroids, anticonvulsants) may exacerbate bone loss, requiring close monitoring of bone health.
• Tenofovir may reduce the absorption of certain drugs, such as didanosine, when taken together, potentially reducing their effectiveness.
• The combination of Tenofovir with nephrotoxic drugs (e.g., cidofovir, acyclovir) should be used cautiously, as both may contribute to renal impairment.
• Tenofovir may interact with antacids containing aluminum or magnesium, reducing its absorption and effectiveness; it is recommended to take these drugs separately by at least 2 hours.
• Use with other hepatotoxic drugs (e.g., alcohol, acetaminophen) may increase the risk of liver damage, particularly in those with pre-existing liver disease.
• Caution is advised when taking Tenofovir with other medications that can affect kidney function or bone mineral density, as there may be an increased risk of adverse effects.

Following are the food interactions to be aware of when taking Tenofovir 300mg Tablets:

• Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of liver problems and could potentially reduce the effectiveness of the drug.
• Ensure adequate hydration and maintain a balanced diet to support overall health and kidney function while on Tenofovir treatment.
• High-fat meals may slightly decrease the absorption of Tenofovir, but this effect is not considered clinically significant.
• Grapefruit and grapefruit juice should be consumed with caution, as they may affect the metabolism of Tenofovir, potentially leading to increased drug levels in the body.
• There is no specific food restriction required with Tenofovir, but maintaining a healthy diet is generally recommended for optimal health.
• Avoid high-sodium foods, as they may interact with Tenofovir and impact blood pressure, especially in individuals with hypertension.
• Caffeine intake should be monitored, as it may interfere with the effectiveness of Tenofovir, although this interaction is not well established.
• Always follow the advice of your healthcare provider regarding dietary considerations and any necessary adjustments during Tenofovir treatment.

The proper storage and disposal of Tenofovir 300mg Tablets are crucial for maintaining their efficacy and safety. Keep the tablets in a cool, dry place, preferably at room temperature, away from sunlight and moisture. Ensure the container is tightly sealed to prevent contamination. Avoid extreme temperatures by not storing them in bathrooms, near stoves, or radiators. Regularly check the expiration date, and if the tablets are expired or no longer needed, do not flush them or pour them down the drain. Contact your pharmacist or healthcare provider for guidance on safe disposal methods. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Tenofovir 300mg Tablet:

• Take the tablet as directed by your doctor, typically once daily with or without food.
• Ensure you stay well-hydrated while taking this medication.
• Take the tablet at the same time each day to maintain consistent drug levels.
• Do not break, crush, or chew the tablet; swallow it whole.
• Inform your doctor if you have any kidney or liver problems before starting this medication.
• Regularly monitor your kidney function and liver enzymes while on this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Keep the medication out of reach of children and pets.