Tenofomide (25mg) 30 Tablets

Tenofovir, the active ingredient in the 25mg tablet, acts as a nucleotide reverse transcriptase inhibitor (NRTI) with activity against human immunodeficiency virus (HIV) replication. Its primary mechanism of action is to interfere with the HIV reverse transcriptase enzyme. Tenofovir is a prodrug that is phosphorylated within the body to its active form, tenofovir diphosphate. This active metabolite competes with the natural substrate deoxyadenosine triphosphate and incorporates into the growing viral DNA chain, resulting in chain termination. By effectively halting the replication process, tenofovir prevents the HIV virus from multiplying and reduces the amount of HIV in the body. This mechanism specifically targets the reverse transcription stage of the HIV life cycle, which is crucial for the virus's ability to infect new host cells.

Nucleoside reverse transcriptase inhibitor

Tablet

The following are the uses of Tenofovir 25mg Tablet:

• Used for treating chronic hepatitis B virus (HBV) infection in adults and children.
• Used as a key component in antiretroviral therapy for HIV, helping to suppress the virus.
• Effective in reducing HIV viral load and improving immune function.
• Helps prevent HIV transmission when used consistently and correctly.
• Used in combination with other antiretroviral drugs for comprehensive HIV management.
• Can be employed as a preventative measure for those at high risk of HIV exposure.
• Provides long-term management and control of HIV and HBV infections.

In the case of an overdose of Tenofovir 25mg Tablet, it is important to recognize the potential risks and take appropriate action. Symptoms of an overdose may include nausea, vomiting, dizziness, and in severe cases, kidney damage or liver problems. If you suspect an overdose, seek medical advice immediately. Prompt treatment can help mitigate any adverse effects and ensure the best possible outcome. Remember, always take medications as directed by your healthcare professional to minimize the risk of overdose.

In the case of a missed dose of Tenofovir 25mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication routine. Consult your healthcare provider if you have any concerns or if you miss multiple doses in a row.

To take Tenofovir 25mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, or as directed by your healthcare provider, typically once daily at the same time each day.

Here are the circumstances under which Tenofovir 25mg Tablet should not be taken:

• Not recommended for individuals with a known hypersensitivity or allergy to Tenofovir or any other ingredients in the medication.
• Should not be used in patients with severe kidney disease or those on dialysis, as dosage adjustments are often required.
• Contraindicated in patients with liver disease, including cirrhosis or significant liver dysfunction.
• Not suitable for children or adolescents under 18 years of age, unless advised by a healthcare professional.
• Avoid using Tenofovir if you have a history of bone problems or risk factors for bone diseases, such as osteoporosis or osteopenia.

The side effects of Tenofovir 25mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Fatigue and weakness
• Headache
• Dizziness
• Skin rashes or itching
• Changes in liver function tests

Following are the precautions and warnings:

• Tenofovir 25mg Tablet should not be used in patients with known hypersensitivity or severe allergic reactions to tenofovir or any of the tablet's components.
• It is crucial to monitor kidney function regularly during treatment, as tenofovir can cause kidney-related side effects. Discontinue or adjust the dose if kidney function worsens.
• Patients with underlying liver disease should exercise caution, as tenofovir may exacerbate liver-related conditions.
• Tenofovir can cause a decrease in bone mineral density, so regular monitoring of bone health is recommended, especially in patients with risk factors for bone-related disorders.
• This medication should be used with caution in patients with hepatitis B or C, as it may affect liver function.
• Patients should be made aware of the potential symptoms of lactic acidosis and instructed to seek medical attention if they experience persistent nausea, vomiting, or unusual fatigue.
• Tenofovir 25mg Tablet may cause muscle-related side effects, including muscle pain and weakness. Patients should report any such symptoms to their healthcare provider.
• Patients should be advised to maintain adequate hydration during treatment to reduce the risk of kidney-related complications.

Following are the drug interactions for Tenofovir 25mg Tablet:

• Didanosine may decrease the effectiveness of Tenofovir, and their combination is not recommended.
• Tenofovir can reduce the renal function of patients taking cidofovir, adefovir, acyclovir, valacyclovir, ganciclovir, valganciclovir, and/or other nephrotoxic medications.
• Co-administration with antacids or other products containing aluminum, calcium, or magnesium may decrease the absorption of Tenofovir.
• The use of Tenofovir with ledipasvir/sofosbuvir or velpatasvir/sofosbuvir may increase the risk of adverse effects, including kidney issues.
• When used with rilpivirine, Tenofovir may require additional monitoring due to potential drug interactions.
• It can interact with probenecid, potentially increasing Tenofovir levels in the body.
• Tenofovir may increase the concentration of certain drugs like atazanavir, increasing the risk of side effects.

Following are the food interactions to be aware of when taking Tenofovir 25mg Tablet:

• Avoid excessive alcohol consumption while on this medication, as it may increase the risk of liver problems and worsen existing liver conditions.
• Ensure adequate hydration by drinking plenty of fluids, especially water, to maintain kidney function and reduce the risk of kidney-related side effects.
• Do not take antacids containing aluminum or magnesium within 2 hours of taking Tenofovir, as they can decrease its absorption.
• High-fat meals may slightly decrease the absorption of Tenofovir, so it is best to take the medication on an empty stomach or with a low-fat meal.
• Avoid or limit the consumption of grapefruit and grapefruit juice as they can increase the levels of Tenofovir in the blood, potentially leading to increased side effects.
• There is no significant interaction with dairy products, but if you have lactose intolerance or milk protein allergy, consider alternative sources of calcium and vitamin D.
• Certain vitamin or mineral supplements, especially those containing calcium or iron, may interfere with Tenofovir absorption. Take them at different times if possible.
• Always consult your healthcare provider or pharmacist for personalized advice regarding food and drug interactions.

Tenofovir 25mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. It is crucial not to store them in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. When disposing of unused or expired tablets, do not flush them down the toilet or pour them into drainage systems. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Additionally, ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Tenofovir 25mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet with a full glass of water to ensure proper swallowing.
• Swallow the tablet whole; do not crush, chew, or break it.
• Maintain a consistent daily routine for taking the medication.
• Inform your doctor if you have any kidney or liver-related issues before starting this medication.
• Regularly monitor your kidney function and liver enzymes while on this medication.
• Stay well-hydrated to reduce the risk of kidney-related side effects.
• Do not share your medication with others, even if they have similar symptoms.