Texcol DM (10mg/5ml) 120ml Syrup

Dextromethorphan, the active ingredient in dextromethorphan syrup/suspension, acts as a non-opioid antitussive or cough suppressant. Its primary mechanism of action involves blocking the activity of specific receptors in the brain, known as N-methyl-D-aspartate (NMDA) receptors, which are involved in the transmission of the cough reflex. By binding to these receptors, dextromethorphan reduces the sensitivity of the cough center in the brain to incoming signals, thereby suppressing the urge to cough. This action helps to alleviate coughing without affecting the central nervous system in a manner that would induce drowsiness or other sedative effects, making it an effective and well-tolerated treatment for cough associated with various respiratory conditions.

dextromethorphan

Antitussive

Suspension

The following are the uses of dextromethorphan Syrup/Suspension:

• Used for temporary relief of coughs caused by minor throat and bronchial irritation
• Used to suppress dry, hacking coughs
• Effective in treating symptoms associated with the common cold, bronchitis, and sinusitis
• Helps reduce coughing fits, allowing for better sleep and rest
• Suitable for treating coughs in patients aged 4 years and older
• Provides short-term relief from non-productive coughs
• May be used as an alternative to codeine for cough suppression

In the case of an overdose of dextromethorphan syrup/suspension, individuals may experience a range of symptoms. These can include dizziness, confusion, and impaired coordination. More severe cases might lead to hallucinations, rapid heart rate, and even seizures. Prompt medical intervention is vital to manage these symptoms effectively, ensuring the well-being of the affected individual. Timely treatment can mitigate the potential risks associated with such an overdose.

In the case of a missed dose of dextromethorphan syrup/suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen.

To take dextromethorphan syrup/suspension, shake the bottle well, measure the prescribed dose with a measuring device, and administer it orally, following the dosage instructions provided by your healthcare provider, typically taken every 4 to 6 hours as needed, without exceeding the maximum daily dose.

Following are the conditions/situations when dextromethorphan Syrup/Suspension should not be used:

• Avoid use in patients with a known allergy or hypersensitivity to dextromethorphan or any of the excipients in the syrup/suspension.
• Do not administer to patients with a history of severe respiratory disorders, such as chronic obstructive pulmonary disease (COPD) or asthma, as it may worsen breathing.
• Contraindicated in patients who are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days, due to the risk of serotonin syndrome.
• Not recommended for individuals with liver impairment, as dextromethorphan is metabolized by the liver.
• Should not be used in patients with a history of seizures or convulsions, as it may lower the seizure threshold.
• Avoid use in patients with gastrointestinal disorders such as gastric ulcers or reflux disease, as it may increase the risk of gastrointestinal bleeding.
• Not suitable for individuals with a history of head injuries or increased intracranial pressure.
• Do not use in patients with a known or suspected substance use disorder.
• Contraindicated in patients with narrow-angle glaucoma.
• Should not be administered to infants or young children under 4 years of age.

The side effects of dextromethorphan syrup/suspension may include:

• Drowsiness or sedation
• Nausea and vomiting
• Constipation or stomach pain
• Dizziness or vertigo
• Dry mouth
• Allergic reactions (skin rash, itching)
• Difficulty urinating
• Confusion or disorientation

Following are the precautions and warnings for dextromethorphan Syrup/Suspension:

• Do not exceed the recommended dosage, as it may lead to serious side effects, including respiratory depression and serotonin syndrome.
• Dextromethorphan should not be used in patients with a known allergy or hypersensitivity to the drug or any of its excipients.
• Caution is advised in patients with underlying medical conditions such as liver or kidney disease, as these conditions may affect the metabolism and elimination of the drug.
• This medication may cause drowsiness or dizziness, so patients should avoid driving, operating heavy machinery, or performing tasks that require mental alertness until they know how the medication affects them.
• Dextromethorphan can interact with other medications, including SSRIs, SNRIs, and MAOIs, potentially leading to serious side effects. Consult a healthcare professional before combining with other drugs.
• Alcohol consumption should be avoided as it can increase the risk of side effects and sedation.
• Dextromethorphan is not recommended for use in children under 4 years old due to the potential risk of serious side effects.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication, as its safety during pregnancy and lactation has not been fully established.

Following are the drug interactions for Dextromethorphan Syrup/Suspension:

• Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated as it can lead to serotonin syndrome, a serious and potentially fatal condition.
• Dextromethorphan may enhance the effects of central nervous system (CNS) depressants like benzodiazepines, alcohol, or other opioids, increasing sedation and respiratory depression risks.
• It can interact with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), potentially leading to serotonin syndrome.
• Antihistamines and anticholinergic drugs may have additive side effects when combined with dextromethorphan, including drowsiness, dry mouth, and blurred vision.
• The effectiveness of some antidepressants, particularly tricyclic antidepressants, may be reduced by dextromethorphan.
• Dextromethorphan can increase the risk of bleeding when taken with anticoagulants or antiplatelet drugs, such as warfarin or clopidogrel.
• Caution is advised when using with certain medications that affect liver enzymes, as it may alter dextromethorphan's metabolism.

Following are the food interactions for Dextromethorphan Syrup/Suspension:

• Avoid consuming alcohol while taking this medication, as it can increase the risk of side effects like dizziness, drowsiness, and impaired coordination.
• Grapefruit and grapefruit juice should be consumed with caution as they can increase the concentration of Dextromethorphan in the blood, potentially leading to increased side effects.
• Avoid high-fat meals as they may slow down the absorption of Dextromethorphan, delaying its effects.
• Avoid taking with hot beverages as it may affect the stability of the medication.
• Avoid consuming dairy products within 1-2 hours of taking Dextromethorphan as calcium can bind with the medication, reducing its absorption.
• Herbal teas and supplements may interact, especially those containing St. John's Wort, kava, or valerian, affecting the metabolism of Dextromethorphan.
• Always follow healthcare provider's instructions for specific dietary recommendations.
• Certain fruit juices, especially those high in antioxidants, may affect the breakdown and absorption of Dextromethorphan.

Dextromethorphan Syrup/Suspension storage and disposal should be handled with care. Store the medication in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the bottle tightly sealed to maintain its integrity and prevent contamination. Avoid storing it in bathrooms or near heat sources as temperature fluctuations can impact its effectiveness. Pay attention to the expiration date, and if the syrup is no longer needed or has expired, do not flush it or pour it down the drain. Contact your pharmacist or healthcare provider for guidance on safe disposal methods. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Dextromethorphan Syrup/Suspension:

• Administer the syrup as directed by your doctor or pharmacist for effective cough suppression.
• Measure the dose accurately using the measuring cup provided to ensure the correct amount is taken.
• Avoid taking more than the recommended dose, as it may lead to serious side effects.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Keep a record of your dosing times to ensure you're taking it as prescribed.
• If you have any concerns or experience persistent symptoms, consult your healthcare provider.
• Do not share the medication with others, as it is prescribed specifically for your condition.