Ticovate (0.5%) 10g Cream

Fluticasone cream, a topical corticosteroid, exerts its therapeutic effects primarily by targeting and modulating the skin's immune response and inflammation pathways. When applied to the skin, fluticasone penetrates the epidermis and binds to corticosteroid receptors within cells, particularly immune cells like lymphocytes and macrophages. This binding triggers a cascade of intracellular events, leading to the suppression of various pro-inflammatory mediators, such as cytokines and chemokines. By inhibiting the production and release of these inflammatory molecules, fluticasone cream effectively reduces redness, swelling, and itching associated with skin conditions. It also inhibits the proliferation of immune cells, further contributing to its anti-inflammatory properties. The localized action of fluticasone on the skin helps to alleviate symptoms without causing systemic side effects, making it a valuable treatment option for certain dermatological conditions.

Fluticasone

Corticosteroid cream.

Cream

The following are the uses of Fluticasone Cream:

• Used for treating various skin conditions like eczema, dermatitis, and rashes.
• Used for reducing inflammation and itching on the skin.
• Used for managing allergic reactions on the skin's surface.
• Used for long-term management of skin conditions to prevent flare-ups.
• Used for providing relief from redness, swelling, and discomfort.
• Used for soothing irritated and sensitive skin areas.
• Used for restoring the skin's natural barrier function.

In the case of an overdose of Fluticasone Cream, it is important to recognize the potential severity of this situation. While the cream is generally safe when used as directed, excessive use can lead to adverse effects. Overdosing may result in an increased risk of systemic side effects, including Cushing's syndrome, adrenal suppression, and skin atrophy. If an overdose occurs, promptly wash the affected area with warm water and seek medical advice. It is crucial to follow the prescribed dosage to avoid such incidents.

In the case of a missed dose of Fluticasone Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. It is generally recommended to use the cream at the same time each day to maintain consistent medication levels in the body. If you frequently miss doses, it is advisable to set reminders or keep the medication in a visible place to help you remember.

To use Fluticasone Cream, gently apply a thin layer to the affected skin areas twice a day, or as directed by your healthcare provider, and rub it in completely.

Following are the conditions/situations when Fluticasone Cream should not be used:

• Should not be used on the face, underarms, or groin area unless prescribed by a healthcare professional.
• Not suitable for individuals who are allergic to any of its ingredients, including fluticasone propionate or any other corticosteroids.
• Contraindicated in patients with skin infections, including bacterial, fungal, or viral infections, at the site of application.
• Should not be used on skin with conditions like rosacea, acne, or perioral dermatitis.
• Avoid using on skin that is broken, cracked, or severely damaged.
• Not recommended for long-term use without medical supervision, as it may cause skin thinning, stretch marks, or other skin changes.
• Do not use on children under 12 years of age without medical advice.
• Avoid using on skin that is showing signs of adverse reactions like severe burning, itching, or irritation.

The side effects of Fluticasone Cream may include:

• Burning or stinging at the application site
• Skin irritation or redness
• Dryness or itching of the skin
• Acne or pimples
• Allergic reactions (such as rash, hives, swelling)
• Skin thinning or discolouration
• Increased hair growth in the treated area
• Changes in skin pigmentation (lightening or darkening)

Following are the precautions and warnings:

• Fluticasone Cream is for external use only and should not be ingested or applied to the eyes, mouth, or other mucous membranes.
• Before using Fluticasone Cream, ensure that the affected area is clean and dry. Wash your hands thoroughly before and after application.
• Avoid using the cream on skin that is broken, infected, or severely burned, unless directed by a healthcare professional.
• Do not cover the treated area with airtight dressings or bandages as this may increase the absorption of the medication.
• Fluticasone Cream should be used with caution in children, and only under the supervision of a doctor.
• If you are pregnant or breastfeeding, consult your doctor before using this medication as it may have potential risks.
• Discontinue use and seek medical attention if you experience any signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing.
• Prolonged use of Fluticasone Cream may result in thinning of the skin, so it is advisable to use the medication only as directed and for the shortest duration needed.

Following are the drug interactions for Fluticasone Cream:

• Fluticasone can interact with other topical steroids, increasing the risk of skin atrophy and striae.
• Concomitant use with other potent CYP3A4 inhibitors like ketoconazole may increase systemic exposure to fluticasone, potentially leading to adverse effects.
• Avoid using Fluticasone with other potent topical corticosteroids, as it may result in increased skin thinning and other local side effects.
• The use of Fluticasone with occlusive dressings or bandages can enhance the absorption of the medication, potentially leading to systemic side effects.
• Anticoagulants like warfarin may experience reduced effectiveness when used with Fluticasone due to its potential to impair wound healing.
• Fluticasone may interact with topical calcineurin inhibitors like tacrolimus, increasing the risk of skin infections and other adverse effects.
• Combining Fluticasone with other immunosuppressant medications may further suppress the immune system, increasing the risk of infections.

Following are the food interactions for Fluticasone Cream:

• Avoid consuming foods with high-fat content as they can potentially increase the absorption of the medication through the skin, leading to higher systemic exposure.
• Citrus fruits like oranges, lemons, and grapefruits may cause skin sensitivity when used alongside Fluticasone Cream, so it's best to avoid them.
• Spicy foods can irritate the skin and exacerbate the symptoms the cream is meant to treat, so it's advisable to limit their consumption.
• Dairy products, especially milk, might interact with the cream, reducing its effectiveness, so consider reducing dairy intake.
• Alcohol can increase skin sensitivity and may cause dryness, so it's recommended to limit alcohol consumption during the treatment period.
• Certain vegetables like tomatoes and peppers can cause a stinging sensation when applied topically, so consider avoiding them while using the cream.
• Avoid caffeine-rich foods and beverages as they may cause vasodilation, increasing blood flow to the skin, and potentially enhancing the absorption of the medication.

Fluticasone Cream should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, heat, and moisture. It is crucial to store the cream in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. When disposing of unused or expired Fluticasone Cream, avoid flushing it down the toilet or pouring it into drainage systems. Instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Always exercise caution to keep the medication out of children's reach to prevent accidental exposure or ingestion. Proper storage and disposal practices are essential to maintain the effectiveness of the cream and ensure safety.

Following are the quick tips for Fluticasone Cream:

• Consult your doctor before using the cream, especially if you have skin infections or other medical conditions.
• Wash your hands thoroughly before applying the cream to ensure cleanliness.
• Apply a thin layer of the cream to the affected area as directed by your healthcare provider.
• Gently rub the cream into the skin until it is fully absorbed for maximum effectiveness.
• Avoid applying the cream to sensitive areas like the eyes, mouth, or open wounds.
• Do not cover the treated area with bandages or tight clothing to allow proper ventilation.
• Store the cream at room temperature, away from direct sunlight and moisture.