Tonoflex (100mg/2ml) 2ml, 5 Ampoule Injections

Tramadol 100mg injection exerts its analgesic effect through a dual mechanism of action. It primarily acts as a μ-opioid receptor agonist, binding to these receptors in the central nervous system to reduce the perception of pain. Additionally, tramadol inhibits the reuptake of norepinephrine and serotonin, leading to increased levels of these neurotransmitters in the synaptic cleft. This dual action enhances its analgesic effect by modulating pain signals and promoting the release of natural pain-relieving compounds in the body. The inhibition of norepinephrine reuptake may also contribute to its potential side effects, such as increased heart rate and blood pressure.

Opioid analgesic

Injection

The following are the uses of Tramadol 100mg injection:

• Used for managing moderate to severe acute pain, providing effective pain relief.
• Used for treating postoperative pain following surgical procedures.
• Used in cases of chronic pain management, including neuropathic pain.
• Used to alleviate pain associated with cancer and palliative care.
• Effective in reducing pain during labor and delivery.
• Can be utilized for procedural sedation, ensuring patient comfort.
• Provides rapid pain reduction in cases of acute musculoskeletal injuries.

To be taken only on the prescription of a doctor and as per doctor's recommendation

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In the case of an overdose of Tramadol 100mg injection, it is crucial to recognize the signs, which may include severe drowsiness, shallow breathing, and pinpoint pupils. The severity of symptoms can vary depending on individual factors. Prompt action is essential, including contacting emergency medical services for immediate assistance. Quick response and medical intervention are vital to managing the overdose and ensuring the best possible outcome for the patient's health and well-being.

In the case of a missed dose of Tramadol 100mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen without compromising its effectiveness. It is crucial to maintain a consistent dosing schedule for optimal pain management.

To administer Tramadol 100mg injection, clean the injection site, insert the needle at a 90-degree angle, and slowly inject the medication as prescribed by your healthcare provider, ensuring proper dosage and following the recommended administration schedule.

Here are the conditions and situations when Tramadol 100mg injection should not be administered:

• Must not be used in individuals with a known allergy or hypersensitivity to Tramadol or any of the excipients in the injection.
• Contraindicated in patients who have experienced severe respiratory depression or asthma attacks when using Tramadol or other similar medications.
• Should not be used in individuals with acute alcohol intoxication or those who have taken sedatives, hypnotics, or other central nervous system depressants.
• Not recommended for patients with severe liver or kidney impairment.
• Contraindicated in patients who are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days.
• Should not be used in individuals with epilepsy or a history of seizures, as it may lower the seizure threshold.
• Must be avoided in patients with head injuries or increased intracranial pressure.

The side effects of Tramadol 100mg injection may include:

• Nausea and vomiting
• Dizziness and drowsiness
• Headaches
• Constipation
• Dry mouth
• Sweating
• Confusion or difficulty concentrating
• Itching or skin rash

Following are the precautions and warnings for Tramadol 100mg Injection:

• Not recommended for individuals with a history of seizures or those who are at a higher risk of seizures, as it may lower the seizure threshold.
• Should be used with caution in patients with respiratory issues, as it can depress respiratory function.
• Not suitable for individuals with severe liver or kidney impairment; dosage adjustments may be necessary for mild to moderate impairment.
• May cause dizziness and drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Elderly patients may be more sensitive to the side effects, and careful monitoring is advised.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• Do not abruptly discontinue the medication; gradual tapering is advised to prevent withdrawal symptoms.
• Keep out of reach of children and pets.

Following are the drug interactions for Tramadol 100mg injection:

• Serotonin syndrome risk is increased when combined with other serotonergic medications, including SSRIs, SNRIs, MAOIs, and triptans.
• May cause severe respiratory depression when used with other central nervous system (CNS) depressants like benzodiazepines, alcohol, or other opioids.
• Tramadol can increase the effects of anticoagulants, such as warfarin, potentially leading to bleeding risks.
• Its effects may be reduced by medications that speed up metabolism, such as carbamazepine and phenytoin.
• Caution is advised with drugs that inhibit CYP2D6 and CYP3A4 enzymes, as they can increase tramadol levels in the body.
• When combined with certain antidepressants (e.g., SSRIs, TCAs), tramadol may increase the risk of side effects like seizures and serotonin syndrome.
• NSAIDs, such as ibuprofen, can increase the risk of gastrointestinal bleeding when used concurrently with tramadol.

Following are the food interactions for Tramadol 100mg injection:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase Tramadol levels in the blood, leading to potential toxicity.
• Alcoholic beverages should be strictly restricted as they can enhance the sedative effects of Tramadol, increasing the risk of dizziness, drowsiness, and impaired breathing.
• Avoid consuming high-fat meals as they may delay the absorption of Tramadol, potentially reducing its effectiveness.
• Caffeinated drinks like coffee or energy drinks might interfere with Tramadol's action, causing restlessness and sleep disturbances.
• Always follow healthcare provider's advice on dietary restrictions during Tramadol treatment.
• Certain herbal supplements like St. John's Wort can interact, potentially reducing Tramadol's efficacy.
• Avoid foods rich in tyramine (aged cheeses, cured meats) as they may interact with Tramadol, causing blood pressure fluctuations.
• Consult a dietician for a balanced diet plan to manage overall health while on Tramadol medication.

Tramadol 100mg injection should be stored in a controlled environment, specifically at room temperature between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the injection from light and do not freeze it to maintain its integrity. Always keep the medication in its original packaging, ensuring the container is tightly sealed. It is crucial to store it in a secure location, out of the reach of children and pets, to prevent accidental ingestion. When disposing of unused or expired Tramadol injection, do not throw it in the trash or pour it down the drain. Instead, utilize authorized medication take-back programs or consult your pharmacist for guidance on safe disposal methods. Proper disposal is essential to prevent environmental contamination and potential harm.

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Following are the quick tips for Tramadol 100mg injection:

• Administer the injection under medical supervision for safety and proper dosage.
• Ensure the injection is stored at room temperature, away from direct sunlight.
• Verify the medication's expiry date before use.
• Use a sterile syringe and needle for injection to prevent infection.
• Inject the medication slowly as directed, typically into a muscle or vein.
• Do not reuse or share needles to prevent the spread of infections.
• If you experience any adverse effects, inform your healthcare provider immediately.
• Dispose of used needles and syringes safely in designated sharps containers.