Transamin (500mg) 5ml Injection

Tranexamic acid, when administered as a 500mg injection, exerts its primary mechanism of action by inhibiting the activation of plasminogen to plasmin. It acts as a competitive antagonist at the lysine binding sites of plasminogen, thereby blocking the conversion of plasminogen to plasmin. This inhibition significantly reduces fibrinolysis, the process responsible for the breakdown of blood clots. By suppressing excessive fibrinolysis, tranexamic acid helps to stabilize existing clots and maintain hemostasis, making it particularly useful in managing conditions where excessive bleeding or fibrinolysis is a concern.

Antifibrinolytic

injection

The following are the uses of Tranexamic Acid 500mg injection:

• Used for controlling heavy bleeding during and after surgeries, especially in cardiac, orthopedic, and gynecological procedures.
• Used for treating severe bleeding caused by injuries, particularly in cases of trauma or accidents.
• Used for managing bleeding disorders such as hemophilia and von Willebrand disease during acute bleeding episodes.
• Used for reducing menstrual bleeding in women with heavy menstrual periods (menorrhagia) when other treatments are ineffective.
• Used for preventing and treating bleeding in the gastrointestinal tract, such as in cases of peptic ulcers or gastrointestinal bleeding.
• Used for controlling bleeding after childbirth (postpartum hemorrhage) to ensure the mother's safety.
• Used for managing bleeding in patients with advanced liver disease or liver cirrhosis who are at risk of bleeding complications.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Menorrhagia- Take 1 tablet of Tranexamic Acid 500mg 3 times a day at mealtimes.
• Surgery or dental surgery- Follow your doctor's instructions.
• Nosebleeds (epistaxis)- Take 500mg 3 times a day.
• Hereditary angioedema- Follow your doctor's instructions.

In the case of an overdose of Tranexamic Acid 500mg injection, symptoms may include nausea, vomiting, diarrhea, and in severe cases, seizures or a decrease in blood pressure. The effects can be more pronounced in individuals with pre-existing medical conditions or those taking other medications. Prompt medical intervention is necessary to manage the symptoms and prevent potential complications. Medical professionals should be contacted immediately to determine the appropriate course of action.

In the case of a missed dose of Tranexamic Acid 500mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to set reminders or use a medication organizer to help you remember to take your medication on time and reduce the chances of missing doses.

To administer Tranexamic Acid 500mg injection, clean the injection site, insert the needle at a 90-degree angle, and slowly inject the prescribed dosage into the muscle, ensuring the entire medication is delivered before withdrawing the needle.

Following are the conditions/situations when Tranexamic Acid 500mg injection should not be administered:

• Must not be used in individuals with a known allergy or hypersensitivity to Tranexamic Acid or any other related aminocaproic acids.
• Contraindicated in patients with active thromboembolic disease or a history of deep vein thrombosis, pulmonary embolism, or arterial thrombosis.
• Should not be used in individuals with severe renal impairment (kidney disease) as it may lead to accumulation of the drug.
• Not recommended for patients with a history of seizures or conditions that increase the risk of seizures, such as head trauma or stroke.
• Should be avoided in patients with severe uncontrolled hypertension (high blood pressure).
• Contraindicated during the active phase of hereditary angioedema due to the risk of triggering further swelling.
• Not suitable for patients with known or suspected retinal hemorrhage.
• Should not be used in patients with known or suspected hypercoagulable states or disseminated intravascular coagulation (DIC).
• Must be used with caution and under medical supervision in patients with a history of blood clots or cardiovascular disease.

The side effects of Tranexamic Acid 500mg injection may include:

• Nausea and vomiting
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Visual disturbances
• Skin rash or itching
• Blood clots (deep vein thrombosis, pulmonary embolism)
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)

Following are the precautions and warnings for Tranexamic Acid 500mg Injection:

• This medication should be used with caution in patients with a history of blood clots, as it may increase the risk of clotting.
• Patients with kidney problems should be closely monitored, as the dosage may need to be adjusted for renal impairment.
• Avoid using Tranexamic Acid if you have a known allergy to it or any of its ingredients.
• It is essential to inform your doctor about any other medications you are taking, especially anticoagulants, as it may interact with them.
• Patients with a history of seizures or epilepsy should use it with caution, as it may increase the risk of seizures.
• Elderly patients may be more sensitive to the effects, so dosage adjustments might be necessary.
• Tranexamic Acid should be used with caution during pregnancy and breastfeeding, and only if the potential benefits outweigh the risks.
• Do not use this medication if you have active bleeding in the brain or other internal bleeding, as it may worsen the condition.

Following are the drug interactions for Tranexamic Acid 500mg Injection:

• Tranexamic Acid may increase the risk of thrombosis (blood clots) when used in combination with other pro-thrombotic drugs (e.g., oral contraceptives, hormone replacement therapy, or anticoagulants).
• Concurrent use with antifibrinolytic agents, such as aminocaproic acid, may increase the risk of excessive clot formation, leading to unwanted clotting complications.
• Caution should be exercised when using Tranexamic Acid alongside anticoagulants (e.g., warfarin, heparin) as it can interfere with their effects, potentially leading to either bleeding or clotting issues.
• Tranexamic Acid may interact with other drugs that affect liver function (e.g., hepatotoxic drugs), potentially altering the metabolism of Tranexamic Acid.
• Combining Tranexamic Acid with diuretics (e.g., furosemide) may increase the risk of kidney damage, so kidney function should be monitored regularly.
• The use of Tranexamic Acid with other fibrinolytic drugs (e.g., tissue plasminogen activator) may increase the risk of bleeding, so it should be avoided unless specifically advised by a healthcare provider.
• Tranexamic Acid may increase the risk of adverse effects when combined with certain antibiotics (e.g., penicillin or cephalosporins) that can affect clotting.
• Caution is advised when using Tranexamic Acid in patients with a history of renal impairment, as it can accumulate in the body, potentially increasing the risk of side effects.

Following are the food interactions for Tranexamic Acid 500mg injection:

• Avoid consuming alcohol with Tranexamic Acid as it may increase the risk of bleeding and liver-related side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect blood clotting and may interact with the medication's blood-thinning properties.
• Foods rich in Vitamin K like leafy green vegetables, broccoli, and liver products should be consumed in moderation as they can counteract the anticoagulant effect of Tranexamic Acid.
• Avoid high-sodium foods as Tranexamic Acid may increase sodium levels in the body.
• Limit the intake of foods high in potassium such as bananas, oranges, and tomatoes as Tranexamic Acid can increase potassium levels.
• Caffeine intake should be monitored as it may affect blood vessels and interact with the medication's action.
• Maintain a balanced diet and stay hydrated to support overall health while using Tranexamic Acid.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific medical conditions or dietary restrictions.

Tranexamic Acid 500mg injection should be stored in a controlled environment, preferably in a cool and dry place at room temperature (20-25°C). Protect the injection from direct sunlight, moisture, and extreme temperatures to maintain its potency. Always keep the medication in its original packaging, ensuring the seal is intact. Do not use if the packaging is damaged or tampered with. Dispose of any unused or expired medication responsibly; do not pour it down the drain or flush it down the toilet. Contact your healthcare provider or pharmacist for guidance on appropriate disposal methods to ensure environmental safety. Keep the injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Tranexamic Acid 500mg Injection:

• Administer the injection under medical supervision for optimal therapeutic effect.
• Ensure proper dosage and duration as prescribed by your doctor.
• Tranexamic acid is typically given slowly into a vein over 10 minutes.
• This medication should only be administered by trained medical professionals.
• Inform your doctor if you have any bleeding disorders or kidney problems.
• Do not inject if the solution is cloudy or contains particles.
• Report any unusual bleeding or bruising to your healthcare provider immediately.
• Store the injection at room temperature, away from direct sunlight and moisture.

Tranexamic acid is a medication often prescribed to treat or prevent excessive blood loss from the uterus. Lab tests are generally recommended for anyone taking this medication to ensure the user's safety and appropriate usage of the medication. These tests vary depending on individual medical conditions and age, but here are some essential lab tests that may be required for someone taking tranexamic acid: