Transamin (250mg) 5ml Injection

Tranexamic acid 250mg injection has a specific mechanism of action that focuses on inhibiting the activation of plasminogen to plasmin, thereby reducing fibrinolysis. It acts as a competitive inhibitor of plasminogen activation, primarily targeting the conversion of plasminogen to plasmin by binding to specific sites on plasminogen molecules. By blocking these binding sites, tranexamic acid prevents the activation of plasminogen by tissue plasminogen activator (tPA) and urokinase (uPA), which are key enzymes in the fibrinolytic pathway. This inhibition helps to stabilize fibrin clots and reduces excessive bleeding by maintaining the integrity of formed blood clots, making it particularly useful in managing conditions where excessive fibrinolysis is a concern.

Fibrinolysis inhibitor

Injection

The following are the uses of Tranexamic Acid 250mg Injection:

• Used for controlling heavy bleeding during and after surgeries, especially in heart, liver, and tooth operations.
• Used for treating and preventing excessive bleeding in conditions like heavy menstrual bleeding, bleeding disorders, and bleeding in the stomach or intestines.
• Used to control bleeding in patients with advanced liver disease or cancer.
• Used to manage bleeding associated with tooth extractions, especially in patients with bleeding risks.
• Used in trauma cases to reduce bleeding and improve survival rates.
• Used to prevent blood clots from forming and to stabilize blood clots that have already formed.
• Used as an emergency treatment for severe bleeding, helping to buy time until more definitive care can be provided.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For heavy menstrual bleeding (menorrhagia)- Take 1 tablet of Tranexamic Acid 250mg 3 times a day, ideally at mealtimes to reduce stomach upset.
• For thrombocytopenia (low platelet count)- The dose will depend on the severity of your condition and your doctor's assessment. The typical starting dose is 1g (1,000mg) daily, divided into 3 smaller doses of 333mg taken at mealtimes. Your doctor may adjust this dose depending on your response and tolerance.
• For dental surgery- The recommended dose is 1 tablet of Tranexamic Acid 250mg taken 2 hours before surgery, followed by another tablet after an hour, and then a third tablet 2 hours after the surgery. This regimen helps reduce the risk of bleeding during and after the procedure.

In the case of an overdose of Tranexamic Acid 250mg Injection, prompt medical attention is necessary. Symptoms may include nausea, vomiting, diarrhea, and in severe cases, seizures or a decrease in consciousness. Immediate treatment involves gastric lavage to remove the medication, followed by supportive care in a medical facility to manage any complications. It is crucial to seek professional help and not attempt home remedies in the event of an overdose.

In the case of a missed dose of Tranexamic Acid 250mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is advisable to set reminders or use a pill organizer to help you remember to take your medication as prescribed.

To administer Tranexamic Acid 250mg Injection, insert the needle into the vial or ampoule, withdraw the prescribed dose into a syringe, and inject it slowly into a vein or muscle as directed by a healthcare professional, ensuring proper aseptic technique and following the recommended dosage guidelines.

Here are the conditions or situations when Tranexamic Acid 250mg Injection should not be administered:

• Contraindicated in individuals with a known allergy or hypersensitivity to Tranexamic Acid or any of its excipients.
• Not to be used in patients with active thromboembolic disease, such as deep vein thrombosis or pulmonary embolism.
• Should be avoided in individuals with a history of blood clots or stroke.
• Not recommended for patients with severe renal impairment or kidney disease.
• Should not be administered to patients with a history of seizures or epilepsy.
• Contraindicated in individuals with a history of retinal hemorrhage or retinal artery or vein occlusion.
• Not suitable for patients with color vision impairment.

The side effects of Tranexamic Acid 250mg Injection may include:

• Nausea and vomiting
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Visual disturbances, such as blurred vision or double vision
• Skin rash or itching
• Allergic reactions, including hives and difficulty breathing
• Thromboembolic events (blood clots) in rare cases

Following are the precautions and warnings for Tranexamic Acid 250mg Injection:

• This medication should be used with caution in patients with a history of blood clots or thromboembolic disorders, as it may increase the risk of clot formation.
• Patients with kidney or liver impairment should be monitored closely, as dosage adjustments may be necessary to prevent accumulation of the drug.
• Tranexamic acid should be used with caution in individuals with a history of seizures, as it may lower the seizure threshold.
• Not recommended for long-term use; prolonged administration may increase the risk of adverse effects.
• Patients undergoing surgery or invasive procedures should inform their healthcare provider, as the medication may need to be temporarily discontinued.
• Elderly patients may be more susceptible to side effects; regular monitoring is advised.
• It is essential to maintain adequate hydration while using this medication to prevent the formation of blood clots.

Following are the drug interactions for Tranexamic Acid 250mg Injection:

• Concomitant use with anticoagulants like warfarin may increase the risk of bleeding. Regular monitoring of coagulation parameters is necessary.
• May reduce the effectiveness of thrombolytic agents like streptokinase or alteplase, used for dissolving blood clots.
• Caution with NSAIDs (e.g., ibuprofen) as the combination may further increase the risk of thrombosis.
• Anticonvulsants like phenytoin may have decreased plasma levels when used with tranexamic acid, potentially affecting seizure control.
• The use of oral contraceptives with tranexamic acid may increase the risk of thrombosis due to their estrogen content.
• Caution when using with antihypertensive medications, as tranexamic acid may elevate blood pressure.
• Can increase plasma concentrations of cyclosporine, a medication used in organ transplantation, requiring close monitoring.

Following are the food interactions for Tranexamic Acid 250mg Injection:

• Avoid consuming grapefruit or grapefruit juice as it may interfere with the absorption of Tranexamic Acid, potentially reducing its effectiveness.
• Alcohol consumption should be limited or avoided as it may increase the risk of bleeding and interfere with the clotting process, counteracting the effects of the medication.
• Avoid high-vitamin K foods like spinach, kale, and broccoli, as Tranexamic Acid can affect blood clotting, and vitamin K plays a role in this process.
• Do not consume energy drinks or beverages with high caffeine content, as they may increase the risk of bleeding and interfere with the medication's action.
• It is best to maintain a balanced diet and avoid excessive intake of fatty foods, as they may affect the overall absorption and metabolism of the medication.
• Stay hydrated by drinking enough water, but avoid excessive fluid intake, especially if you have kidney-related concerns.
• Consult your healthcare provider for specific dietary recommendations, as they may provide personalized advice based on your medical condition and treatment plan.

Tranexamic Acid 250mg Injection should be stored in a cool, controlled environment, ideally between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the injection from light and moisture by storing it in its original packaging or a suitable container, ensuring it remains tightly sealed. It is crucial to keep the medication away from children and pets to prevent accidental exposure. Do not freeze the injection or expose it to excessive heat, as this can compromise its integrity. Always check the expiration date, and dispose of any unused or expired medication responsibly, following local guidelines for pharmaceutical waste disposal.

Following are the quick tips for Tranexamic Acid 250mg Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the medication's identity and expiry before use.
• Administer the injection as prescribed, usually intravenously or intramuscularly.
• Do not inject if the solution is discolored or contains particles.
• Dispose of used needles and syringes safely in a puncture-proof container.
• Inform your doctor if you have any bleeding disorders or kidney problems.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Seek immediate medical attention if severe allergic reactions or excessive bleeding occur.

Tranexamic acid is a medication that is typically prescribed to treat or prevent excessive blood loss from wounds or during menstrual periods. It is in the category of drugs called fibrinolytics, which help stabilize blood clots and prevent excessive bleeding. While laboratory tests are not required for everyone who takes tranexamic acid, certain monitoring may be done to ensure the safety and effectiveness of the medication. This will depend on several factors, including the prescription of the medication, dosage and duration of treatment, and individual health conditions and comorbidities.Some factors that influence the need for laboratory tests include: