Tritace (10mg) 28 Tablets

The mechanism of action of Ramipril is primarily through its inhibition of the angiotensin-converting enzyme (ACE). ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure. By blocking ACE, Ramipril reduces the production of angiotensin II, leading to vasodilation. This relaxation of blood vessels results in decreased peripheral resistance and reduced blood pressure. Additionally, the inhibition of ACE increases the levels of bradykinin, a vasodilator peptide, further contributing to the overall blood pressure-lowering effect. Ramipril's action also promotes natriuresis, the excretion of sodium in the urine, which helps in reducing blood volume and subsequently lowers blood pressure.

Angiotensin-converting enzyme (ACE) inhibitor.

Tablet

The following are the uses of Ramipril 10mg Tablet:

• Used for treating high blood pressure (hypertension) to reduce the risk of heart attacks, strokes, and heart failure.
• Used for improving survival after a heart attack and preventing further complications.
• Used for managing heart failure, helping the heart pump blood more efficiently.
• Used for protecting the kidneys in diabetic patients with high blood pressure.
• Used for reducing protein loss in urine for kidney-related issues.
• Used for treating certain types of chronic pain, particularly in diabetic neuropathy.
• Used for improving blood flow and oxygen supply to tissues.

Dosage is based on your medical condition and response to treatment

In the case of an overdose of Ramipril 10mg Tablets, it is important to recognize the potential symptoms and take appropriate action. An overdose may lead to symptoms such as severe dizziness, fainting, or a significant drop in blood pressure. If you suspect an overdose, seek medical advice promptly. Contact your healthcare provider or local poison control center for guidance, as they can provide specific instructions for managing the situation effectively. Timely intervention is key to ensuring the best possible outcome.

In the case of a missed dose of Ramipril 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance on how to safely resume your medication without affecting its efficacy.

To take Ramipril 10mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically once daily.

Following are the conditions/situations when Ramipril 10mg Tablet should not be used:

• Should not be taken by individuals with a known allergy to Ramipril or other ACE inhibitors.
• Contraindicated in patients with a history of angioedema, a serious allergic reaction.
• Not suitable for patients with a narrowing of the aortic heart valve (aortic stenosis).
• Should not be used during pregnancy, especially in the second and third trimesters.
• Contraindicated in patients with bilateral renal artery stenosis.
• Not recommended for individuals with severe kidney disease or those on dialysis.
• Should be avoided in patients with uncontrolled low blood pressure (hypotension).
• Discontinue use if experiencing excessive vomiting or diarrhea, as it may lead to dehydration.
• Do not administer to patients undergoing desensitization therapy for insect stings or those receiving immunosuppressive therapy.
• Should not be used in children or adolescents under 18 years of age.

The side effects of Ramipril 10mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Dry cough
• Headache
• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Altered sense of taste

Following are the precautions and warnings for Ramipril 10mg Tablet:

• Do not start or continue Ramipril if you have a known allergy to any of its ingredients.
• This medication requires caution in patients with kidney or liver disease, as it may require dosage adjustments or close monitoring.
• Ramipril can cause dizziness or lightheadedness, especially when standing up suddenly; patients should rise slowly to prevent falls.
• Patients with a history of angioedema should exercise caution, as this drug may increase the risk of this condition.
• Avoid excessive alcohol consumption while taking Ramipril, as it may increase the risk of side effects.
• Diabetic patients should monitor their blood sugar levels regularly, as Ramipril can affect blood sugar control.
• Pregnant or breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus or infant.

Following are the drug interactions for Ramipril 10mg Tablet:

• Potassium-sparing diuretics (e.g., spironolactone, eplerenone) may increase the risk of hyperkalemia when used with Ramipril, requiring close monitoring of potassium levels.
• The combination of Ramipril with other angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) can lead to excessive blood pressure lowering and increased side effects.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen may reduce the antihypertensive effect of Ramipril and increase the risk of kidney dysfunction.
• Ramipril can potentiate the effects of antihypertensive drugs and diuretics, leading to hypotension and possible renal impairment.
• Lithium levels may be increased by Ramipril, requiring close monitoring and possible dose adjustment.
• The effectiveness of diabetic medications, including insulin, may be altered by Ramipril, necessitating glucose level monitoring.
• When used with immunosuppressants, Ramipril may increase the risk of infection and affect the therapeutic response.

Following are the food interactions for Ramipril 10mg Tablet:

• High potassium foods like spinach, avocado, and bananas should be consumed in moderation as Ramipril may increase potassium levels in the body.
• Salt substitutes or potassium supplements should be used with caution as they can also raise potassium levels.
• Alcohol can lower blood pressure further and increase the risk of dizziness, so it should be consumed in moderation or avoided.
• Avoid excessive licorice consumption as it can decrease the effectiveness of Ramipril.
• Grapefruit and grapefruit juice may increase the levels of Ramipril, so it's best to avoid or limit their intake.
• Maintain a balanced diet as directed by your doctor, focusing on low-sodium and low-potassium foods.
• Follow the dietary recommendations provided by your healthcare professional for optimal blood pressure control.

Ramipril 10mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to heat or freezing temperatures, as this can compromise its effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them down the toilet or discard them in household waste. Consult your pharmacist or local waste management guidelines for appropriate disposal methods. Keep the medication away from children and pets to prevent accidental consumption. Always practice responsible storage and disposal to ensure the safety and efficacy of Ramipril 10mg Tablets.

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Following are the quick tips for Ramipril 10mg Tablet:

• Start with a low dose and gradually increase as advised by your doctor.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a full glass of water, preferably in the morning.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose.
• Avoid getting up too fast from a sitting or lying position to prevent dizziness.
• Regularly monitor your blood pressure and kidney function while on this medication.