Tritace (5mg) 28 Tablets

Ramipril, the active ingredient in Ramipril 5MG Tablet, primarily exerts its therapeutic effects through the inhibition of the angiotensin-converting enzyme (ACE). ACE is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure. By blocking the action of ACE, ramipril prevents the formation of angiotensin II, leading to reduced vasoconstriction and lowered blood pressure. This mechanism contributes to its effectiveness in managing hypertension and heart failure. Additionally, the reduced angiotensin II levels result in decreased aldosterone secretion, promoting diuresis and further lowering blood pressure. Ramipril's action also leads to a decrease in blood volume and vascular resistance, thereby improving cardiovascular function and reducing the workload on the heart.

ACE inhibitor

Oral

The following are the uses of Ramipril 5MG Tablet:

• Used for treating high blood pressure, helping to reduce strain on the heart and arteries.
• Used for managing heart failure, improving symptoms and enhancing quality of life.
• Used to prevent further complications in patients who recently had a heart attack.
• Used to slow down the progression of kidney damage, particularly in diabetics.
• Used to lower the risk of stroke and heart attack in high-risk individuals.
• Used to manage certain chronic pain conditions, such as migraines.
• Used for treating Raynaud's phenomenon, reducing the frequency and severity of attacks.

Dosage is based on your medical condition and response to treatment

In the case of an overdose of Ramipril 5MG Tablets, it is important to recognize the potential severity of this situation. Initial symptoms may include a rapid drop in blood pressure, leading to lightheadedness or dizziness. More serious effects can manifest as severe hypotension, causing fainting or even shock. Immediate medical intervention is necessary to manage these symptoms and prevent potential harm to vital organs, particularly the kidneys and liver, which may be affected by prolonged low blood pressure.

In the case of a missed dose of Ramipril 5MG Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Ramipril 5MG Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Ramipril 5MG Tablet should not be taken:

• Should not be used in individuals with a known allergy to Ramipril or other angiotensin-converting enzyme (ACE) inhibitors.
• Contraindicated in pregnant women, especially during the second and third trimesters.
• Not suitable for individuals with a history of angioedema, either hereditary or associated with previous ACE inhibitor therapy.
• Should not be used in patients with bilateral renal artery stenosis or unilateral renal artery stenosis in a solitary kidney.
• Contraindicated in individuals with severe liver impairment or liver disease.
• Should not be given to patients with a history of aortic stenosis or outlet obstruction.
• Not recommended for individuals undergoing major surgery or anesthesia.

The side effects of Ramipril 5MG Tablet may include:

• Dizziness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Diarrhea
• Dry cough
• Skin rash or itching
• Altered sense of taste

Following are the precautions and warnings:

• Ramipril 5MG Tablet should not be used in patients who are allergic to any of its ingredients, including ramipril or other ACE inhibitors.
• Patients with a history of angioedema should exercise caution as this medication may cause swelling of the face, lips, tongue, or throat.
• Close monitoring of kidney function is required while taking this medication, especially in patients with existing kidney problems.
• It may cause a drop in blood pressure, so caution is advised, especially in patients with low blood pressure or those on diuretic medications.
• Diabetic patients should be aware that Ramipril may increase blood sugar levels. Regular monitoring is necessary.
• Not recommended for use during pregnancy, especially in the second and third trimesters, as it may cause harm to the fetus.
• Breastfeeding women should consult their doctor as Ramipril may pass into breast milk and potentially harm the nursing infant.
• Patients with impaired liver function should be cautious as Ramipril is primarily metabolized in the liver. Regular liver function tests may be required.

Following are the drug interactions for Ramipril 5MG Tablet:

• Ramipril may increase the blood pressure-lowering effects of other antihypertensive medications, such as beta-blockers or calcium channel blockers, leading to excessive hypotension.
• The use of Ramipril with angiotensin receptor blockers (ARBs) or aliskiren in patients with diabetes is contraindicated due to the increased risk of renal impairment.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the antihypertensive effect of Ramipril and may increase the risk of renal impairment.
• Lithium levels may be increased when used with Ramipril, requiring close monitoring.
• When combined with diuretics, particularly potassium-sparing diuretics, Ramipril may cause hyperkalemia (high potassium levels).
• Ramipril can enhance the hypoglycemic effects of insulin or oral antidiabetic drugs, potentially leading to low blood sugar.
• The use of Ramipril with other ACE inhibitors or angiotensin receptor neprilysin inhibitors (ARNIs) may increase the risk of angioedema.
• Certain medications metabolized by the liver, such as cyclosporine, may have increased blood levels when used with Ramipril, requiring dosage adjustments.

Following are the food interactions to be aware of when taking Ramipril 5MG Tablet:

• Avoid consuming high-sodium foods like processed snacks, canned soups, and certain condiments, as Ramipril can lead to increased sodium retention.
• Limit your potassium intake, as Ramipril may increase potassium levels. Avoid excessive consumption of bananas, oranges, tomatoes, and leafy greens.
• Alcohol can lower your blood pressure further and may increase the risk of dizziness or lightheadedness, so it's best to minimize or avoid alcohol.
• Grapefruit and grapefruit juice should be consumed with caution, as they can affect the metabolism of Ramipril, potentially leading to increased drug levels in the body.
• There is no specific requirement to take Ramipril with food, but it may be advisable to take it with a meal to reduce the risk of gastrointestinal upset.
• Avoid excessive consumption of licorice, as it can interfere with the body's balance of potassium and sodium, potentially affecting blood pressure.
• Stay well-hydrated by drinking enough water, especially during hot weather or when physically active.

Ramipril 5MG Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to external elements. It is crucial to adhere to the recommended storage conditions to preserve the medication's effectiveness. When disposing of unused or expired tablets, do not flush them down the toilet or discard them into the drainage system. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to minimize environmental impact. Keep the medication securely stored, away from children and pets, to prevent accidental consumption.

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Following are the quick tips for Ramipril 5MG Tablet:

• Start with a low dose and gradually increase as directed by your doctor to minimize side effects.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a full glass of water, preferably in the morning.
• Avoid taking Ramipril with high-sodium foods or drinks as it may reduce its effectiveness.
• If you experience persistent cough, dizziness, or lightheadedness, consult your doctor promptly.
• Inform your doctor about all medications you're taking to avoid potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not stop taking Ramipril without consulting your doctor to prevent potential complications.