Ubetril (24/26mg) 14 Tablets

Sacubitril/valsartan is a combination medication that works through the synergistic actions of its two components. Sacubitril, an neprilysin inhibitor, blocks the breakdown of natriuretic peptides, leading to increased levels of these peptides. This results in vasodilation, reduced blood pressure, and decreased cardiac remodeling. Valsartan, an angiotensin II receptor blocker, blocks the effects of angiotensin II, a hormone that causes vasoconstriction and increases blood pressure. By blocking the angiotensin II receptors, valsartan prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to further vasodilation, reduced blood pressure, and improved cardiac function. Together, sacubitril and valsartan enhance the beneficial effects of the natriuretic peptide system while inhibiting the renin-angiotensin-aldosterone system, ultimately leading to improved cardiovascular outcomes in patients with heart failure or hypertension.

Angiotensin Receptor Blocker (ARB)

Tablet

The following are the uses of Sacubitril 24mg, Valsartan 26mg Tablet:

• Used for treating heart failure, improving heart function and reducing the risk of hospitalization.
• Used to lower blood pressure and reduce strain on the heart.
• Used to enhance patient quality of life by reducing symptoms like shortness of breath and fatigue.
• Used to slow the progression of heart failure and improve long-term outcomes.
• Used in cases where standard treatments have not been effective, offering an alternative approach.
• Used to manage a specific type of heart failure, known as reduced ejection fraction.

In the case of an overdose of Sacubitril 24mg and Valsartan 26mg Tablets, symptoms may include severe hypotension, increased serum potassium levels, and renal impairment. Prompt medical intervention is necessary, focusing on supportive measures to maintain vital functions. Treatment may involve monitoring and managing vital signs, fluid balance, and electrolyte levels, as well as providing respiratory support if needed. Seeking medical advice and treatment is crucial for managing the potential risks associated with an overdose of this medication.

In the case of a missed dose of Sacubitril 24mg, Valsartan 26mg Tablet, it is recommended to take the missed dose as soon as you remember, provided there is a reasonable gap until your next scheduled dose. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for advice on how to improve adherence.

To take Sacubitril 24mg, Valsartan 26mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Here are the conditions or situations when Sacubitril 24mg, Valsartan 26mg Tablet should not be used:

• Must not be used in patients with a known allergy to Sacubitril, Valsartan, or any other ACE inhibitor or Angiotensin II Receptor Blocker (ARB).
• Contraindicated in individuals with a history of angioedema related to previous ACE inhibitor or ARB therapy.
• Should not be used during pregnancy, especially in the second and third trimesters, as it can cause harm to the fetus.
• Not recommended for individuals with severe liver impairment.
• Avoid use in patients with bilateral renal artery stenosis or unilateral renal artery stenosis in a solitary kidney.
• Not suitable for individuals with hereditary angioedema.
• Discontinue use if significant hyperkalemia (high potassium levels) occurs during treatment.

The side effects of Sacubitril 24mg, Valsartan 26mg Tablet may include:

• Dizziness or lightheadedness
• Cough
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea
• Low blood pressure (hypotension)
• Increased potassium levels in the blood (hyperkalemia)
• Elevated liver enzymes

Following are the precautions and warnings for Sacubitril 24mg, Valsartan 26mg Tablet:

• Do not use if you are allergic to Sacubitril, Valsartan, or any other ACE inhibitors.
• This medication may cause fetal harm; it is not recommended for use during pregnancy or in women planning to become pregnant.
• Patients with a history of angioedema should exercise caution as this medication may increase the risk of this condition.
• Regular monitoring of kidney function is necessary, especially in patients with pre-existing kidney disease.
• Blood pressure should be closely monitored, and dose adjustments may be required if significant drops in blood pressure occur.
• Patients with a history of liver disease should have their liver function monitored while on this medication.
• Not recommended for use in children as its safety and efficacy have not been established in the pediatric population.

Following are the drug interactions for Sacubitril 24mg, Valsartan 26mg Tablet:

• Potassium-sparing diuretics (e.g., spironolactone, eplerenone) may increase serum potassium levels when used with this medication, requiring close monitoring.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen may reduce the antihypertensive effect of this medication and increase the risk of kidney impairment.
• The combination of Sacubitril/Valsartan with angiotensin-converting enzyme (ACE) inhibitors can increase the risk of angioedema and may cause significant hypotension.
• Sacubitril/Valsartan may increase the blood levels of lithium, leading to lithium toxicity. Lithium levels should be monitored closely.
• When used with other antihypertensive medications, including beta-blockers and calcium channel blockers, blood pressure may drop excessively, requiring dosage adjustments.
• This medication may interact with other drugs that affect the renin-angiotensin system, such as direct renin inhibitors, potentially leading to increased side effects.
• Sacubitril/Valsartan may enhance the effects of certain diabetes medications, increasing the risk of hypoglycemia. Blood glucose monitoring is advised.

Following are the food interactions for Sacubitril 24mg, Valsartan 26mg Tablet:

• Avoid consuming high-sodium foods like processed snacks, canned soups, and condiments, as Valsartan's blood pressure-lowering effect may be reduced.
• Limit the intake of potassium-rich foods such as bananas, oranges, and spinach, as Sacubitril can increase potassium levels.
• Avoid excessive alcohol consumption, as it may increase the risk of dizziness and affect blood pressure control.
• Grapefruit and grapefruit juice should be consumed with caution, as they can interfere with the metabolism of Valsartan, potentially leading to increased blood levels of the drug.
• Maintain a balanced diet, as Sacubitril/Valsartan may cause a modest increase in blood glucose levels.
• Stay hydrated and monitor fluid intake, especially if you have a history of kidney problems.
• Consult a healthcare professional for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Sacubitril 24mg, Valsartan 26mg Tablets should be stored in a dry and cool environment, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. Avoid placing the tablets in bathrooms or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly by consulting a pharmacist or healthcare professional for guidance, rather than discarding them through the toilet or sink. Additionally, keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Sacubitril 24mg, Valsartan 26mg Tablet:

• Always take the tablet as directed by your doctor; do not alter the dosage.
• Ensure you swallow the tablet whole with a sufficient amount of water.
• Maintain a consistent schedule for taking the medication, preferably at the same time daily.
• If you experience difficulty swallowing, consider taking the tablet with a small amount of water or food.
• Avoid crushing or chewing the tablet to prevent a bitter taste.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your blood pressure and consult your doctor for adjustments if needed.