Vagibact (2%) 40g Cream

Clindamycin cream works by inhibiting bacterial protein synthesis. It specifically targets the 50S subunit of the bacterial ribosome, which is responsible for the production of proteins essential for bacterial growth and survival. The active ingredient in the cream, clindamycin, binds to this subunit, preventing the formation of peptide bonds and ultimately leading to the cessation of bacterial protein synthesis. This mechanism effectively stops the growth and multiplication of susceptible bacteria, particularly those commonly associated with skin infections, such as Staphylococcus aureus and Streptococcus pyogenes. By disrupting their ability to synthesize proteins, clindamycin cream helps to control and eliminate the bacterial presence on the skin.

Clindamycin

Lincosamide Antibiotic

Cream

The following are the uses of Clindamycin Cream:

• Used for treating bacterial skin infections, reducing inflammation, and preventing the spread of infection.
• Used for acne, effectively targeting and reducing acne-causing bacteria.
• Used for skin abscesses, helping to drain and heal the affected area.
• Used for folliculitis, an inflammation of hair follicles, providing relief and healing.
• Used for post-surgery skin infections, ensuring proper healing and preventing complications.
• Used for preventing infection in minor cuts, scrapes, or burns, promoting faster recovery.
• Used for reducing skin redness and irritation caused by bacterial overgrowth.

To be applied once daily as a thin layer on affected area or as prescribed by doctor

In the case of an overdose of Clindamycin Cream, it is important to recognize the potential severity of the situation. While rare, applying excessive amounts of the cream may lead to increased local skin irritation or systemic absorption, resulting in adverse effects. If a significant amount of the cream has been ingested, seek medical advice promptly. It is crucial to act swiftly and consult a healthcare professional for guidance to ensure appropriate management and prevent any potential complications.

In the case of a missed dose of Clindamycin Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed application and continue with your regular schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed and to determine whether any adjustments to your treatment plan are necessary.

To use Clindamycin Cream, clean and dry the affected area, then apply a thin layer of the cream to the skin, gently rubbing it in as directed by your healthcare provider, typically twice a day or as prescribed.

Following are the conditions or situations when Clindamycin Cream should not be applied:

• Must not be used if you are allergic to clindamycin, lincomycin, or any other ingredients in the cream.
• Avoid using it if you have a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.
• Do not use on children under the age of 1 month, especially for diaper dermatitis.
• Do not apply to broken or blistered skin.
• Do not use if you have a staph infection (Staphylococcus aureus infection).
• Not suitable for individuals with a history of severe gastrointestinal diseases.

The side effects of Clindamycin Cream may include:

• Skin irritation at the application site
• Redness or itching
• Dryness or peeling of the skin
• Burning or stinging sensation
• Contact dermatitis (skin rash)
• Allergic reactions (skin rash, hives, itching)
• Diarrhea (in rare cases)
• Increased sensitivity to sunlight

Following are the precautions and warnings for Clindamycin Cream:

• Avoid using Clindamycin Cream if you are allergic to clindamycin, lincomycin, or any other ingredients in the cream.
• Do not apply the cream near your eyes, nose, mouth, or other mucous membranes.
• Wash your hands thoroughly before and after applying the cream to avoid accidental transfer to sensitive areas.
• If you are using other topical medications, apply Clindamycin Cream at least 1 hour before or after other medications to prevent possible interactions.
• Inform your doctor if you have a history of gastrointestinal diseases, as Clindamycin may cause diarrhea or other gastrointestinal issues.
• Discontinue use and consult a doctor if you experience severe or persistent skin irritation, redness, or swelling at the application site.
• Keep Clindamycin Cream out of the reach of children and pets. Store it at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Clindamycin Cream:

• Erythromycin and other macrolide antibiotics may compete for the same binding sites, reducing the effectiveness of both drugs.
• Topical use with benzoyl peroxide can cause skin irritation and dryness.
• Concomitant use with retinoids can lead to increased skin sensitivity and potential skin peeling.
• Clindamycin may decrease the effectiveness of hormonal contraceptives, requiring additional birth control methods.
• It can interact with topical steroids, increasing the risk of skin atrophy and striae.
• Combining with other topical antibiotics may increase the risk of bacterial resistance.
• Topical vitamin A derivatives may cause skin reactions when used with Clindamycin.

Following are the food interactions for Clindamycin Cream:

• Alcohol-based products should be avoided in the areas where Clindamycin Cream is applied, as they can cause skin irritation and dryness.
• There is no specific food restriction while using Clindamycin Cream, but maintaining a healthy diet can support overall skin health.
• Avoid oily and greasy foods, as they may increase skin oiliness and potentially affect the absorption of the medication.
• Some citrus fruits like oranges, lemons, and grapefruits may cause photosensitivity when used with Clindamycin Cream, so limit their consumption.
• Dairy products might increase the chances of developing acne, so moderate intake is advisable.
• Avoid spicy foods as they can potentially irritate the skin, especially if you have sensitive skin or skin conditions.
• Staying well-hydrated by drinking plenty of water can support skin hydration and overall health.
• Consult your healthcare provider for personalized advice regarding any specific dietary considerations or restrictions.

Clindamycin Cream should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the cream in its original container, tightly sealed, to maintain its integrity and protect it from light and moisture. Avoid storing it in bathrooms or areas exposed to heat or moisture, as these conditions can degrade the medication. Always check the expiration date before use, and properly dispose of any expired or unused cream. Do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance. Ensure the cream is kept out of the reach of children and pets to prevent accidental contact or ingestion.

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Following are the quick tips for Clindamycin Cream:

• Apply a thin layer to the affected area as directed by your doctor.
• Cleanse the skin gently before applying the cream.
• Wash your hands before and after application to avoid spreading the infection.
• Use the cream for the full prescribed length of time, even if symptoms improve.
• Avoid applying the cream near your eyes, nose, mouth, or open wounds.
• Do not cover the treated area with bandages or tight clothing.
• Store the cream at room temperature, away from moisture and heat.