Valtec AMH (5/160/12.5mg) 28 Tablets

The combination of Valsartan, Hydrochlorothiazide, and Amlodipine in this tablet has a synergistic effect on blood pressure control. Valsartan blocks the angiotensin II receptor type 1, reducing the vasoconstrictive and aldosterone-secreting effects of angiotensin II, which leads to decreased blood pressure. Hydrochlorothiazide, a thiazide diuretic, inhibits the reabsorption of sodium and chloride in the distal tubule of the kidney, increasing diuresis and promoting a reduction in blood volume and blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and a decrease in peripheral resistance, which further contributes to lowering blood pressure. Together, these mechanisms effectively reduce blood pressure by targeting multiple pathways involved in vascular tone and fluid balance.

Angiotensin II Receptor Blocker, Thiazide Diuretic, Calcium Channel Blocker

Tablet

The following are the uses of Valsartan 160mg, Hydrochlorothiazide 12.5mg, Amlodipine 5mg Tablet:

• Used for treating high blood pressure
• Used to manage hypertension-related conditions
• Used to improve blood flow and reduce strain on the heart
• Used for preventing cardiovascular events such as stroke or heart attack
• Used to regulate blood pressure and fluid balance
• Used as a long-term treatment option for hypertension management
• Used in combination to enhance blood pressure control
• Used to lower blood pressure and prevent complications

To be taken as per doctor's prescription

In the case of an overdose of Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg Tablet, symptoms may include dizziness, rapid or irregular heartbeat, and a sudden drop in blood pressure. This combination of medications can lead to severe health complications, such as fainting, difficulty breathing, and even cardiac arrest. Immediate medical intervention is necessary, including contacting poison control or seeking emergency medical care to prevent potential life-threatening consequences. Prompt action is crucial to ensure the best possible outcome.

In the case of a missed dose of Valsartan 160mg, it is recommended to take the tablet as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. For Hydrochlorothiazide 12.5mg, if a dose is missed, take it as soon as possible on the same day, but avoid taking it too close to the next day's dose. Regarding Amlodipine 5mg, if a dose is missed, take it as soon as you remember, unless it's almost time for your next dose. Do not double the dose to make up for a missed one.

To take the Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare provider.

Following are the conditions/situations when Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg Tablet should not be used:

• Should not be used in patients with a known allergy to any of the components, including Valsartan, Hydrochlorothiazide, or Amlodipine.
• Contraindicated in patients with a history of angioedema or a known sensitivity to other angiotensin II receptor blockers (ARBs).
• Should not be used in pregnant or breastfeeding women.
• Not recommended for individuals with severe renal impairment or patients on dialysis.
• Should be avoided in patients with severe liver disease or biliary obstruction.
• Contraindicated in patients with anuria (lack of urine production).
• Not suitable for individuals with low blood pressure (hypotension) or those who have recently experienced a heart attack.
• Should not be used in patients with a history of aortic stenosis (narrowing of the aortic valve).
• Avoid in patients with hyperkalemia (high potassium levels) or conditions that may cause it.
• Discontinue use if there is evidence of liver dysfunction or jaundice.

The side effects of Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Skin rash or itching
• Swelling in the legs, ankles, or feet (peripheral edema)
• Low blood pressure (hypotension)

Following are the precautions and warnings for Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg Tablet:

• Patients with known allergies to any of the active ingredients (valsartan, hydrochlorothiazide, or amlodipine) or other related medications should not take this tablet.
• Regular monitoring of kidney function is necessary, especially in patients with pre-existing kidney disease, as this medication may affect kidney function.
• It may cause a decrease in blood pressure, so caution is advised when standing up from a sitting or lying position to prevent dizziness or fainting.
• Diabetic patients should be cautious as hydrochlorothiazide can alter blood sugar levels. Regular monitoring is advised.
• Electrolyte imbalances can occur with hydrochlorothiazide, so regular blood tests are recommended to monitor potassium, sodium, and magnesium levels.
• This medication may not be suitable for pregnant or breastfeeding women. Consult your doctor for alternative treatment options.
• Patients with severe liver disease should exercise caution as amlodipine is metabolized by the liver.
• Do not consume grapefruit or grapefruit juice while taking this medication, as it can affect the metabolism of amlodipine.

Following are the drug interactions for Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg Tablet:

• Lithium levels can be increased by thiazide diuretics like Hydrochlorothiazide, potentially leading to lithium toxicity.
• Valsartan may increase the risk of angioedema when combined with Angiotensin-Converting Enzyme (ACE) inhibitors.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Valsartan and Amlodipine.
• Amlodipine can enhance the hypotensive effects of other antihypertensive medications.
• Hydrochlorothiazide may increase blood calcium levels, which should be monitored when used with calcium supplements or other drugs that affect calcium levels.
• Grapefruit juice can increase the blood levels of Amlodipine, potentially leading to increased side effects.
• Drugs metabolized by the CYP3A4 enzyme may have altered concentrations when used with Amlodipine, as it is a moderate inhibitor of CYP3A4.
• Combining Valsartan with potassium-sparing diuretics or potassium supplements may lead to hyperkalemia.

Following are the food interactions for Valsartan, Hydrochlorothiazide, and Amlodipine Tablet:

• Avoid excessive salt or sodium intake, as Hydrochlorothiazide is a diuretic and can lead to increased urination and electrolyte imbalance.
• Limit potassium-rich foods like bananas, oranges, and tomatoes as Valsartan may increase potassium levels.
• Grapefruit and grapefruit juice should be avoided with Amlodipine, as it can increase the drug's concentration in the blood, leading to potential side effects.
• Dairy products like milk and yogurt can interfere with the absorption of these medications, so consider spacing out medication and dairy intake.
• Alcohol can lower blood pressure further when combined with these medications, so moderation is advised.
• Avoid high-fat meals as they may affect the absorption of these drugs.
• Maintain a consistent fluid intake to prevent dehydration, especially with Hydrochlorothiazide's diuretic effect.

Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg tablets should be stored in a cool, dry place, ideally at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the medication in its original packaging, tightly sealed, to maintain its integrity. Avoid exposing the tablets to extreme temperatures, such as those found in bathrooms or near heat sources, as this can compromise their effectiveness. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Avoid flushing or pouring the medication down the drain; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep all medications securely stored, out of the reach of children, to prevent accidental consumption.

No

Following are the quick tips for Valsartan 160mg, Hydrochlorothiazide 12.5mg, and Amlodipine 5mg Tablet:

• Take the tablet as directed by your doctor, usually once daily.
• Swallow the tablet whole with a full glass of water, preferably at the same time each day.
• You can take this medication with or without food, but be consistent.
• Avoid crushing, chewing, or breaking the tablet, as it may affect its effectiveness.
• Do not skip doses; maintain a consistent medication schedule.
• Inform your doctor if you have any kidney or liver problems before taking this medication.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.