Warfarin (2mg) 100 Tablets

Warfarin 2mg tablets work by blocking the production of vitamin K-dependent clotting factors in the liver. Specifically, warfarin inhibits the enzyme vitamin K epoxide reductase (VKOR), which is essential for the recycling of vitamin K1. Vitamin K is a crucial cofactor in the synthesis of clotting factors II, VII, IX, and X, as well as proteins C and S. By inhibiting VKOR, warfarin reduces the availability of active vitamin K, leading to decreased production of these clotting factors. This results in a longer clotting time, as the blood's ability to form clots is impaired, thereby preventing existing clots from growing larger and reducing the risk of new clots forming.

Oral anticoagulant

Tablet

The following are the uses of Warfarin 2mg Tablet:

• Used for preventing and treating harmful blood clots in conditions like deep vein thrombosis and pulmonary embolism.
• Used for reducing the risk of blood clots after certain types of surgery or medical procedures.
• Used for managing and preventing strokes in patients with atrial fibrillation.
• Used to lower the chances of heart attacks and blood vessel blockages.
• Used for long-term treatment in individuals with a history of blood clots.
• Used for preventing clot formation in artificial heart valves.
• Used to maintain blood flow and prevent complications in certain blood vessel conditions.

In the case of an overdose of Warfarin 2mg Tablets, the primary concern is excessive bleeding, which can lead to severe health complications. Symptoms may include easy bruising, prolonged bleeding from wounds, nosebleeds, and blood in urine or stool. Immediate medical intervention is necessary, as it may require hospitalization for monitoring and treatment. Management includes administering vitamin K to counteract the effects of Warfarin and supporting the patient with transfusions if significant bleeding occurs. Prompt action is vital to prevent potentially life-threatening consequences.

In the case of a missed dose of Warfarin 2mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Never double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for advice on how to proceed, as it may require a specific adjustment to your dosing regimen to ensure the medication's effectiveness and your safety.

To take Warfarin 2mg Tablets, swallow the tablet whole with a full glass of water, usually once or twice a day, as directed by your doctor, preferably at the same time each day to maintain consistent blood levels.

Following are the conditions or situations when Warfarin 2mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Warfarin or any other anticoagulant medications.
• Contraindicated in people with bleeding disorders or a history of bleeding in the brain.
• Not suitable for patients with severe uncontrolled high blood pressure.
• Should not be used in individuals with stomach or intestinal ulceration or bleeding.
• Contraindicated during pregnancy as it can cause harm to the fetus.
• Not recommended for individuals with recent or impending surgery, including dental procedures.
• Should be avoided in patients with severe kidney or liver disease.
• Not suitable for individuals with a history of stroke or transient ischemic attack (TIA).
• Should be used with caution and regular monitoring in elderly patients.
• Contraindicated in people with a history of blood clots in the spinal cord.

The side effects of Warfarin 2mg Tablet may include:

• Easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from cuts)
• Blood in urine or stools
• Persistent headache or dizziness
• Weakness, fatigue, or general feeling of illness
• Dark urine or pale stools
• Yellowing of the skin or eyes (jaundice)
• Hair loss
• Skin necrosis (skin damage or death of skin cells)

Following are the precautions and warnings for Warfarin 2mg Tablet:

• Warfarin should be used with caution in individuals with a history of bleeding disorders, stomach ulcers, or liver disease, as it may increase the risk of bleeding.
• Regular blood monitoring is essential to ensure the correct dosage and to avoid excessive blood thinning.
• Patients should inform their doctor about all medications, supplements, and herbal products they are taking, as many substances can interact with Warfarin and affect its effectiveness.
• Dental procedures or surgeries should be planned carefully, and the treating doctor must be informed about Warfarin use to prevent excessive bleeding.
• Patients should maintain a consistent diet, as sudden changes in dietary vitamin K intake can affect the drug's action.
• Avoid activities with a high risk of injury or trauma, as Warfarin may increase bleeding from wounds.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks, as it can cross the placenta and may cause harm to the fetus or newborn.
• Elderly patients may require lower doses and more frequent monitoring due to age-related changes in metabolism and increased sensitivity to the drug's effects.

Following are the drug interactions for Warfarin 2mg Tablet:

• Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) can increase the risk of bleeding when taken with Warfarin.
• Certain antibiotics, such as sulfamethoxazole/trimethoprim and metronidazole, may affect Warfarin's metabolism, requiring close monitoring of INR (International Normalized Ratio).
• Antifungal medications like fluconazole can increase Warfarin's effect, potentially leading to excessive bleeding.
• Drugs that affect the central nervous system, including antidepressants (e.g., SSRIs) and antipsychotics, may interact with Warfarin, necessitating INR monitoring.
• Vitamin K supplementation can reduce Warfarin's effectiveness, so consistent intake of vitamin K-rich foods is essential.
• Some herbal supplements like St. John's Wort and Ginkgo Biloba may decrease Warfarin's efficacy.
• Certain medications used in cancer treatment, such as tamoxifen, can impact Warfarin's anticoagulant effect.

Following are the food interactions for Warfarin 2mg Tablet:

• Avoid excessive consumption of foods rich in vitamin K, such as spinach, kale, broccoli, Brussels sprouts, and green leafy vegetables. These foods can decrease the effectiveness of Warfarin.
• Maintain a consistent diet and avoid sudden changes in vitamin K intake. Fluctuations in dietary vitamin K can affect the stability of your blood clotting time.
• Cranberry juice and cranberry products should be consumed in moderation as they may interact with Warfarin, potentially affecting its effectiveness.
• Limit alcohol intake as excessive alcohol consumption can increase the risk of bleeding and may affect the metabolism of Warfarin.
• Herbal supplements like garlic, ginger, ginkgo biloba, and St. John's Wort should be used cautiously as they may influence blood clotting and interact with Warfarin.
• Fish oil supplements and vitamin E supplements may increase the anticoagulant effect of Warfarin, so consult your healthcare provider before taking them.
• Avoid large doses of vitamin K supplements as they can reduce the effectiveness of Warfarin and require careful monitoring.
• Maintain a balanced and consistent diet, and inform your healthcare provider about any significant dietary changes or the use of herbal supplements.

Warfarin 2mg Tablets should be stored in a cool, dry area, preferably in a sealed container at room temperature, away from moisture and light. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Avoid exposing the medication to extreme temperatures, such as inside a car during hot weather or near heating devices, as this can impact its effectiveness. Always check the expiration date, and never use the tablets after this date. For proper disposal, do not flush or pour the medication down the drain; instead, consult a pharmacist or healthcare professional for safe disposal methods, ensuring that it is kept away from children and pets to prevent accidental ingestion.

Following are the quick tips for Warfarin 2mg Tablet:

• Always take the tablet as directed by your doctor; do not adjust the dosage without medical advice.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Warfarin is often taken once daily in the evening, but follow your doctor's instructions.
• You may need regular blood tests to monitor the drug's effectiveness and adjust the dosage.
• Inform your doctor about all medications and supplements you take to prevent interactions.
• Avoid sudden changes in diet, especially foods high in vitamin K, as it can affect the drug's action.
• Carry identification that indicates your use of warfarin in case of emergencies.