Xatral SR (5mg) 28 Tablets

Alfuzosin is an alpha-1 adrenergic blocker used primarily to treat benign prostatic hyperplasia (BPH). Its mechanism of action involves selective inhibition of alpha-1 adrenergic receptors, which are found in the smooth muscle of the prostate gland, bladder neck, and urethra.

Alfuzosin dosage recommendations are:

• Benign Prostatic Hyperplasia - 10 mg once daily, taken after a meal.
• Lower Urinary Tract Symptoms - 10 mg once daily, taken after a meal.

Contact your local hospital Accident and Emergency department straight away. Tell the doctor or nurse how many tablets you have taken. Lie down as much as possible to help stop the side effects. Do not try to drive to the hospital yourself.

Do not take a double dose to make up for a forgotten tablet. Miss it out and then go on as before.

Swallow the tablet whole with a glass of water. Do not crush or chew the tablet, as this can affect how the medication is released in your body.Stay well-hydrated, and avoid sudden changes in position to minimize the risk of dizziness.

Do not use alfuzosin and inform your doctor:

• If you are allergic to alfuzosin or any of its ingredients. Allergic reactions can include rash, difficulty swallowing or breathing, and swelling of the lips, face, throat, or tongue.
• If you are taking other alpha-blockers, as this could cause adverse interactions.
• If you have postural hypotension, a condition where blood pressure drops upon standing, causing dizziness, light-headedness, or fainting.
• If you have severe liver problems.

Vertigo, dizziness, headache, GI upset. Orthostatic hypotension, syncope, tachycardia, palpitations, chest pain, fatigue, drowsiness rash, pruritus, flushes, oedema, asthenia, malaise, dry mouth.

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QT prolongation, hypertension; monitor BP regularly, particularly at start of treatment. Coronary insufficiency; discontinue if angina deteriorates. Withdraw 24 hours before anaesthesia. Renal or hepatic impairment. Cerebral circulatory disorders. Risk of priapism; warn patients to seek immediate medical assistance. Cataract surgery. Elderly

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Drug interactions with alfuzosin include:

• Ketoconazole (increases alfuzosin levels, risk of hypotension)
• Itraconazole (increases alfuzosin levels, risk of hypotension)
• Ritonavir (increases alfuzosin levels, risk of hypotension)
• Clarithromycin (increases alfuzosin levels, risk of hypotension)
• Erythromycin (increases alfuzosin levels, risk of hypotension)
• Nitrates (increases risk of hypotension)
• PDE5 inhibitors (increases risk of hypotension)
• Alpha-blockers (additive hypotensive effect)
• Antihypertensives (additive hypotensive effect)
• Cyclosporine (increases alfuzosin levels, risk of hypotension)
• Dantrolene (risk of severe hypotension)

The food interactions that should be considered while using Alfuzosin are:

• Food increases the extent of absorption.

Alfuzosin require specific storage conditions to maintain their effectiveness. Store the product in a cool, dry place, away from direct heat, light, and moisture. The ideal temperature range for storage is between 15°C and 30°C, and it’s important to ensure that the container remains tightly closed to prevent contamination. For safety purposes, keep Xatral SR tablets out of reach of children and pets to avoid accidental ingestion. It is also advised to avoid storing the medication in areas prone to humidity or warmth, such as bathrooms or kitchens. If you have any concerns or questions about proper storage, consult your doctor or pharmacist for further guidance to ensure the product’s quality and safety.